The IV and oral DMPK profiles of compounds 3, 4, 10, 16, and 23 were evaluated in a 1 mg/Kg cassette dose experiment in C57Bl/6 mice.
Four of the compounds demonstrated essentially identical profiles with short half-lives, high clearance, and low oral bioavailability. Compound 4 (GSK2945) was differentiated from the group with a longer half-life of 2.0 h and an oral bioavailability of 23%, despite the higher cLogP of the compound (Table 2 and Supporting Information Figure 4).
[...]
The remaining four compounds (3, 10, 16, 23) would be suitable for acute time-of-day dosing by injection where short exposure of the compound at meaningful levels in desired
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Sr9009 is #3
Even the most promising #4 only had 2hr half life an oral bioavailability of 23%.
So sr9009 is even less.
1mg/kg
So a 150lb person taking 150mg of the promising compound at 23% would only get you around 34mg to last a couple hours then you'd want to dose another 150...
With sr9009, you'd get even less, with less time in the system
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347663/#!po=27.2321
In case you want to read the 112 page study
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