does mdht reduce sex hormone binding globulin the same way that proviron does?
Does it actually aromatize or is it metabolized too quickly? I thought it was the latter but if it's due to aromatization couldn't one use 5AR and AI inhibitors?The free test aromatizes too quickly for it to have any benefit. The thought that Proviron will actually have any benefit by increasing free test is a myth.
Yes metabolized, not aromatize. My error.Does it actually aromatize or is it metabolized too quickly? I thought it was the latter but if it's due to aromatization couldn't one use 5AR and AI inhibitors?
Bobo, are there any benefit to supplements that claim to increase free testosterone by manipulating binding compounds like SHBG?The free test aromatizes too quickly for it to have any benefit. The thought that Proviron will actually have any benefit by increasing free test is a myth.
Bump for info on this. Avena Sativa is supposed to reduce SHBG, and obviously there are new products coming out (activate etc) that purport to do this, is it worthwhile, or will the increased free test simply be metabolized to rapidly to realise any benifits?Bobo, are there any benefit to supplements that claim to increase free testosterone by manipulating binding compounds like SHBG?
IMO, the body tries to maintain an even keel (and adjusts to compensate) so to speak so theres little/no benefit.
IMO, no.Bobo, are there any benefit to supplements that claim to increase free testosterone by manipulating binding compounds like SHBG?
From the research I have seen, any increase in free test will metabolize too quickly to see any benefit at all. I posted on this subject a while back.Bump for info on this. Avena Sativa is supposed to reduce SHBG, and obviously there are new products coming out (activate etc) that purport to do this, is it worthwhile, or will the increased free test simply be metabolized to rapidly to realise any benifits?
Albumin bound T cannot directly aromatize, at least from the studies I've seen. T binds weakly to albumin so it is likely that they unbind and that T can bind to the AR. Albumin bound T is protected from metabolism and aromatization.Well, can albumin bound test aromatize? It is bioavailiable too...
Umm....albumin bound testosterone and SHBG bound testosterone does not exert any effects on surrounding tissues.
http://www.mindandmuscle.net/content/page-214.htmlThe major binding protein, Sex Hormone Binding Protein (SHBG) is responsible for carrying between 60 – 70% of the body’s testosterone through the bloodstream. The testosterone that is bound to SHBG is bound so tightly that it is considered biologically inactive. Virtually all the remaining testosterone is bound loosely to a number of other binding proteins, the main one being albumin. Only about 2% of the body’s testosterone circulates free, or unbound. However, as mentioned, the testosterone that is albumin bound is only attached very loosely to this transport protein and so is able to interact with the androgen receptor as if it were free. Hence it, like free testosterone, is considered to be biologically active. The free and albumin bound testosterone together are called the bioactive or bioavailable fraction.
http://www.mdsdx.com/MDS_Diagnostic_Services/Patients/TestInfo/Special/Malemenopause.aspTestosterone is present in the circulation both in protein bound (96%) and in non-protein bound ('free' or unbound) formats. In males, about 44% is bound to Sex Hormone Binding Globulin (SHBG), 50% to albumin and 2-3% 'free' (1).
Until recently it was believed that only the 'free' fraction of testosterone could be taken up by tissues and the protein-bound testosterone complex was inactive. It has now been demonstrated that the albumin bound fraction of testosterone readily dissociates and is absorbed up by the tissues along with the 'free' fraction. Together, these two fractions are referred to as the bioavailable testosterone (Bio-T) fraction.
As Bobo alluded to earlier, various forms of injectible T are already bound to esters that help prevent metabolization. Albumin bounding would be redundant. To increase the bioavailability of endogenous T levels reducing SHBG bound T with a corresponding increase in Albumin bound T may be of some benefit. The key is to determine at what rate albumin bound T disassociates and what may be the rate limiting factors.ersatz, that is what I am proposing...why not create a albumin bound testosterone for injection...that way there is no risk for metabolism and aromitization...
Why would you want to eliminate the estrogenic effects? That would decrease GH, IGF-1 and mRNA translocation.Albumin bound test would not aromatise, which would take away a lot of the estrogenic related sides...bah whatever, I have no education in this subject so maybe im just retarded lol...
In terms of being bioavailble yes, but the scenario is completely different as normal HTPA functions shut down and the levels present are far higher the normal physiological levels of free test. Free test simply refers to bioavailable test. Injectables also have various esters attached for longer half-lives and increased circultation. Homeostasis isn't achieved using injectable forms. Normal physiological levels will always attempt to achieve homeostasis since normal HTPA functions are still present.
I mean compete at the hypothalamus, blocking the negative feedback effect of bioavailable T. Unlike HCG, the the hypothalamous would continue to tell the pituitary to produce LH and FSH. I recently questioned this claim when a product claimed to do just that.What you do mean? As in block (lack of a better term) suppression from increased testosterone like HCG?
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