Definitely space them out as evenly throughout the day as you can to maintain stable blood levels as stated above. Also take your support supps between PH doses as far away as you can.
Example:
Epi/Tr3n 7am, 2pm, 9pm (depending on your waking and bedtime as evenly spaced as possible)
Support Supps: 11am or 5pm
What dosages of each do you plan on taking?