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    FREE--FREE--FREE--FREE>>>>Product!


    I want to thank bobo for his quick professional service!

    I urge all to read the cAMPHIBOLIC Series at synergymuscle.com Karl "nandi" Hoffman. We are truley excited about this product.

    Not to shy away from matters, I am currently running a Fun contest on the boards I sponsor.

    I am looking for the best response not the first response. The winner will recieve a 2 FREEE bottles of cAMPHIBOLIC "Post cycle theraphy Monster" at synergymuscle.com. You can quote research but the answer orginal writing(so copy and paste jobs).

    Winner will be chosen Monday. ENJOPY


    calpain/calpastatin

    What is it?

    Would a bodybuilder want to inhibit or Activate the system?why.

    Cortisol

    what is it?

    Would a bodybuilder want to inhibit or Activate the system?why.


    Again, the best overall answer wins and your not limited to one anwer. Take your nootrophic and impress with intelligence!

    ceosm

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    Calpain is a calcium dependant protein degrading enzyme. It breaks down muscles in the body by removing z discs and m lines in myofibrils. There are two types of calpain, m-calpain which requires more calcium than the other type, μ-calpain to become active. Calpain can also degrade cartilage, and an excess of active calpain can lead to rheumatoid arthritis.

    Obviously calpain would be undesired when it comes to bodybuilding.

    Calpastatin is an ihibitor of calpain. It regulated the amount of active calpain in cells, as there is enough calpain in muscles to destroy them in 10 minutes. An increase of antibodies against calpastatin can lead to muscle atrophy and cartilidge degredation. Also, Calpain/Calpastatin activity is different in double-muscled bulls (like the myostatin bull)
    An introduction or activation of calpastatin would lead to less active calpain, and as a result muscle hypertrophy.



    Cortisol section coming later...
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    Cortisol is a steroid hormone that metabolizes carbohydrates and protein. It is released by the cortex of the adrenal glands. Cortisol is produced when corticotropin releasing hormone (CRH) produced by the hypothalamus releases adrenocorticotropic hormone (ACTH). The ACTH is sensed by the cortex of the adrenal glands, and cortisol is released. There several factors that determine the amount of cortisol produced. Stress can increase the amount of cortisol in the body, as can illness, extreme temperatures, and physical exertion (why you shouldn't do 3 hour workouts).

    Cortisol can increase blood pressure, blood-sugar levels, glycogen formation in the liver, and inhibits immune system function and can inhibit bone growth. A very large increase of cortisol of a period of time causes Cushing's syndrome, which symptoms include round face, edema, fat gain, cartilidge degredation, bone weakening, and severe musclular atrophy. Cortisol can be used to treat asthma or emphysema, and can be used to treat allergic reactions.

    If cortisol could be inhibited, muscle growth and fat loss could be acheived.
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    Keep the comming! The winner will be announced on Monday!

    ceosm
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    Copied this into the supp forum as well
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    For answers to board issues, read the Suggestion and News forum at the bottom of the main page.
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    cortisol


    Cortisol
    Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.

    Cortisol production has an ACTH-dependent circadian rhythm with peak levels in the early morning and a nadir at night. The factor controlling this rhythm is not completely defined and can be disrupted by a number of physical and psychological conditions. ACTH and cortisol are secreted independent of circadian rhythm in response to physical and psychological stress.

    Elevated cortisol levels and lack of diurnal variation have been identified with Cushing’s disease (ACTH hypersecretion). Elevated circulating cortisol levels have also been identified in patients with adrenal tumors. Low cortisol levels are found in primary adrenal insufficiency (e.g. adrenal hypoplasia, Addison’s disease) and in ACTH deficiency. Due to the normal circadian variation in cortisol levels, distinguishing normal from abnormally low cortisol levels can be difficult, therefore several daily collections are recommended.

    Interpretation of Results
    Cortisol levels in saliva reflect the active unbound compound. Cortisol is measured in ng/ml.

    Salivary Cortisol Ranges for Women and Men

    A.M. 1.0 - 8.0

    P.M. 0.1 - 1.0




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    bud


    Quote Originally Posted by RRAdam
    Cortisol is a steroid hormone that metabolizes carbohydrates and protein. It is released by the cortex of the adrenal glands. Cortisol is produced when corticotropin releasing hormone (CRH) produced by the hypothalamus releases adrenocorticotropic hormone (ACTH). The ACTH is sensed by the cortex of the adrenal glands, and cortisol is released. There several factors that determine the amount of cortisol produced. Stress can increase the amount of cortisol in the body, as can illness, extreme temperatures, and physical exertion (why you shouldn't do 3 hour workouts).

    Cortisol can increase blood pressure, blood-sugar levels, glycogen formation in the liver, and inhibits immune system function and can inhibit bone growth. A very large increase of cortisol of a period of time causes Cushing's syndrome, which symptoms include round face, edema, fat gain, cartilidge degredation, bone weakening, and severe musclular atrophy. Cortisol can be used to treat asthma or emphysema, and can be used to treat allergic reactions.

    If cortisol could be inhibited, muscle growth and fat loss could be acheived.
    WINNER MY MAN!!

    Please e-mail address to ceosm@synergymuscle.com

    THANK YOU FOR PLAYING!

    ceosm
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    good job.
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