Originally Posted by ersatz
Most people are under the idea that it would hinder gains. The reasoning is that anything that improves liver function will cause the product to be deactivated/excreted more rapidly. From what I've seen this doesn't appear to be the case and I feel it's better to err on the side of caution and thusly use some liver protectant while on. It won't significantly hinder any gains so I would run it at 1g/day.
We dont really have a clear answer. I think that the matter is more complex and milk thristle is on the accusation chair.
This is from an interview to Poliquin by W. Lewellyn (very interesting read btw):
WL:
Can you explain what you mean by a detox protocol?
CP: They use a program to get rid of the metabolites. So like calciumd-glucurate.They’ll use what they basically call “pushers�,which are large injections of detoxing compounds,and they use mainly botanical liver detoxifiers that don’t mess up the androgen sites like milk thistle, which will actually decrease steroid absorption.
WL:
I also know that milk thistle has an anti-inflammatory effect, inhibiting the conversion of arachidonic acid to active prostiglandins. This also would be a negative for muscle growth.
CP: Yeah, milk thistle is not popular. Guys definitely stick with other botanicals.They also use botanicals to increase free testosterone during the detox or clean-up phase.
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