it'll depend on how experienced, or inexperienced you are.
experienced, you'll be able to notice the subtle, minor changes.
inexperienced, you'll also be able to notice what will prob seem like drastic changes.
those in between will think it's garbage, and doesn't work, and there will prob be those who it doesn't work for.
one thing to remember, they aren't methylated oral compounds, nor are they injectable compounds. they are pro hormones taken orally.