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Bulk Up or Alpha Mass?

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    8ATHLETE's Avatar
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    why will it affect the effectiveness of alpha mass just curious

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    Any updates yet on MAX BULK? There's lots of folks waiting for this product line...
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    Quote Originally Posted by svida View Post
    Any updates yet on MAX BULK? There's lots of folks waiting for this product line...
    a lot of reps waiting for the product line as well haha....we're all chomping a the bit to try all the products
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    Bulk Up or Alpha Mass?


    Quote Originally Posted by 8ATHLETE View Post
    why will it affect the effectiveness of alpha mass just curious
    The other product contains naringenin, which is an extremely potent 17b-hsd inhibitor. That is a critical enzyme that facilitates the conversions of Dhea's to diols and testosterones. In other words it will block prohormones from converting to anything other than Dione's (the weakest).
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    Quote Originally Posted by Royd The Noyd View Post
    The other product contains naringenin, which is an extremely potent 17b-hsd inhibitor. That is a critical enzyme that facilitates the conversions of Dhea's to diols and testosterones. In other words it will block prohormones from converting to anything other than Dione's (the weakest).
    This is interesting. I had never heard of this effect before, only that it could possibly modulate estrogen along with extending the half-life of certain drugs. But, my question is how much effect would Naringenin really have in human body with regards to enzyme inhibition? Would it really be that noticible? I also could only find 2 studies that seemed to relate to this enzyme inhibition, but one said it inhibited 3b-hsd, the other 17b-hsd. Maybe it inhibits both, but then again to what degree?

    Perhaps the amount effective for extending the half-life of compounds isn't great enough to cause enough inhibition to be noticable. Both the Andro Series by PP and these AndroFactory clones use Naringenin, but I don't recall anyone ever raising the issue of enzyme inhibition with Primordial's products. The enzyme inhibition seems to be intrinsically tied to the CYP P450 inhibition. If that is the case, wouldn't your hormone carrier run into the same issue? Just speculating on that; I'm too tired to search for yet another ingredient right now. Besides which, just because it isn't in a study doesn't mean that that is not the case; the oposite is also true at times.

    Maybe it is just a case of six of one, half a dosen of the other. Longer half-life and less conversion vs. shorter half-life and more conversion.

    These are the only two studies that I could pull up that seemed relevant: http://www.ncbi.nlm.nih.gov/pubmed/23370353 and http://www.ncbi.nlm.nih.gov/pubmed/11205867 .
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    def interesting here can't say I've ever heard of this being a problem either
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    does lg science have good products?
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    id use frl or AF rather than lg....
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    why? lg has been in the hormone business for a long time, i'd say they know a thing or two about what they're doing.
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    Quote Originally Posted by hvactech View Post
    id use frl or AF rather than lg....
    Why? Agreed on FRL though

    Quote Originally Posted by jbryand101b View Post
    why? lg has been in the hormone business for a long time, i'd say they know a thing or two about what they're doing.
    ^ This
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    Quote Originally Posted by jbryand101b View Post
    why? lg has been in the hormone business for a long time, i'd say they know a thing or two about what they're doing.
    Could be why their formulator has helped other companies formulate some of their products as well.
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    Quote Originally Posted by Royd The Noyd View Post
    The other product contains naringenin, which is an extremely potent 17b-hsd inhibitor. That is a critical enzyme that facilitates the conversions of Dhea's to diols and testosterones. In other words it will block prohormones from converting to anything other than Dione's (the weakest).
    WTF?? Why would they put that in their product?
  

  
 

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