I've been using UR off and on for about six months. I started with the origional caps but even at 18/day they did nothing for me. I understand Pat has made the new version more bioavailable. I switched to UR spray. Sparying once a day, It did nothing for the first two weeks (it takes a while to build in your system). During the third week I started to notice some subtle changes but then I ran out of spray and it was out-of-stock for about a month so I re-ordered and started over. This time I began spraying twice/day. I'm now in my fourth week and once again the changes have been subtle. I'm not sure there is a big advantage to spraying twice/day. Once you system is saturated I don't think that taking more provides much of an advantage. Moreover, spraying your entire body twice/day is a pain and double the cost. I think there may some wisdom in double dosing for the first two weeks and then reverting to a once/day maintenance dosage. Don't expect this stuff to "rock your world". It does work but it takes time. Plan ahead. Pat only makes small runs of this stuff and its out of stock more than in.