Wanted to start a post to get some definitive (or closest to it), intelligent opinions/perspectives on the concept of single dosing orals in a day versus spreading the doses out. I've read sensible opinions on both sides.
What's the half life of the compound in question? Are you looking for stable levels or a spike? Are there certain side effects (positive/negative) that make dosing certain times of the day beneficial or less hindering? And more. Too vague of a question in my opinion. Needs clarification of what the oral is and what goals are.
my sides are way worse with a single dose
it depends on the compounds half life and if you can handle the sides, you want a definitive answer , you really need to be more specific. i.e lets say your doing SD at 20mgs a day , imo is take one(10mgs)in the moring and one about (10mgs)8-10hrs later , if its "on" a work out day id take my second dose about an hour before my session, if you train in the am id take about an hour that session. 8-10hrs later my second dose.
What ph are you interested in? Every compound is different.
For example: 1AD made me very sleepy so I took it before bed. MDHT gave me a nice psyche boost shortly after taking so I took pre workout.
If your wondering more about suppression, again depends on the compound but anything worth taking is going to shut you down regardless.
thx for replies. not referring to any compounds specifically. Duchaine, Llewelyn, and a member of this board share the commonality of dosing your orals once per day versus spread out. the opinions of these guys did not concern half-lives of compounds--just simply to dose orals all at the same time each day. their reasoning was to achieve the greatest peak blood levels and they also suggested it would reduce suppression. Again, they were NOT concerned with different compounds, whether it be D-bols, SD, winny, whatever--just pop em all at once, once per day. Just made me stop n think since 90% of folks say to pop based on half-life.
Do they also suggest dosing test enanthate monthly to get spikes? lol
Typically you want anabolic compounds at as close to constant concentration as feasible.
Again, depends on the compound, but for what it sounds like you're looking for the answer would be: take things like Superdrol throughout the day; taking it all at one time will shut you down just as much as staggering.
If you are going to waste any time and money on these orals, IMHO, you just just run them along with a nice testosterone cycle and worry about suppression after your carefully prepared PCT is finished. If it's worth doing it's worth doing right a wise man one told me, a thousand times.
Each substance has a 1/2 life in the body. This is the time it takes for the concentration of the substance to decrease by 1/2. Thus, the higher the concentration, the faster the body is metabolizing the compound. By shooting for a more steady concentration, you are essentially maximizing the concentration over time (the area under the curve if you plotted concentration vs. time).
Maybe there is a reason for maximizing blood concentration, but you would also be maximizing the rate your body is getting rid of the compound (unless it's rate limited for some reason).
There could definitely be a reason, ie. receptor binding being increased by increased blood concentration, but now you introduce variables such as binding affinity, and that is compound specific. Just so you know, I'm just postulating at this point.
Most say that im a narcissistic guy,its ok as long as they keep talking about me. also,they are right,i always want to shine,but this is more than vanity, this is my passion, my principles, so call me narcissistic, i call you frustrated.
You may be right. May also depend on the compound as well. Do I want a continuous steady level to keep promoting growth or a peak concentration near workouts to promote strength or aggression etc. /shrug
It doesn't matter, just do whatever you want. Making a bigger deal out of this than it has to be.
Try dosing a cycle each way, then decide what you like better.
"If you want to impress me, build a 20-inch arm with a 20-pound dumbbell."~Dan Duchaine
SNS REP, Precision Nutrition Lvl 1, NSCA CPT
I agree with jbryand.
and we all respond differently