PDE-5 Inhibitors (Think Viagra) and what they can do for you even w/o ED*A Must Read* - AnabolicMinds.com

PDE-5 Inhibitors (Think Viagra) and what they can do for you even w/o ED*A Must Read*

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    Cool PDE-5 Inhibitors (Think Viagra) and what they can do for you even w/o ED*A Must Read*


    *Not sure if this is right section, but it is geard to aas users mostly and alot only check the aas section, so I think its good here but move if needed*
    *Yes I made this, it is not a rip off, I just posted it at a couple other places under same name*

    ENJOY!

    So Today I want to touch on PDE5 Inhibitors.

    What is that you ask?

    Think “Viagra” or “Cialis”.

    PDE5 Inhibitors are drugs used to block the degrading action of “phosphodiesterase type 5 on cyclic GMP in the smooth muscle cells lining the blood vessels supplying the corpus cavernosum of the penis.” These drugs are used in the treatment of erectile dysfunction some people suffer from.

    Phosphodieste-WHAT?

    Phosphodiesterase are enzymes that are often targets for pharmacological inhibition because of their tissue/blood distribution effects.[1] In our case we are talking about the blood flow to the penis.

    But my package works just fine, why should I even learn about this stuff?

    Well I hope you never truly need a PDE5 Inhibitor but the truth is some may at some point or another.
    Today I will be focusing on the use of these compounds for during or post AAS cycle use, while recovering (PCT).
    Even though I am going to be focusing this article on the use of PDE5 Inhibitor use connected to AAS users, keep in mind that is not the only application for a product like this!
    Some even feel it aids their workouts taking a small dose pre-workout and gives them extra “pump”.
    It may even be used to treat some diseases!

    I have myself used Yohimbe pre-WO (it acts kind of like Viagra) and I think it did help with pumps, but I would not take pharmaceutical PDE5’s just for your workouts daily. But that’s just me because I feel it may be a bit of a waste.
    A good pre-wo should give you a rush and pumps if needed, save the Viagra or CIA for the good stuff! :-D

    Anyway back on topic;

    Erectile dysfunction can be caused by a bunch of things like; diabetes, prostate cancer, AAS use, depression, multiple sclerosis, heart disease and so on.[1]

    Did you know even low ESTROGEN levels can cause libido issues!?!?


    A lot don’t know this and that can come back to bit them in the butt!

    Why would I have low estrogen levels?


    Well some people might be trying to get rid of their gyno by mega dosing Letro or another AI and possibly for long durations (I don’t recommend). They could use one of these PDE5 compounds to help out during that time or at least minimize issues down there.

    Another reason might be someone just using too much of an AI while on cycle or even just having a bad cycle layout due to a lack of knowledge or bad info.
    Estrogen is used in a lot of functions in the body that are needed; keep that in mind when lowering your estrogen with an AI!

    But if I do a “Good PCT” doesn’t that mean I won’t have erection issues?

    Well even with a good PCT, some people might have issues with libido and/or erections while in PCT or even post PCT.

    If my libido is shot for a few weeks what’s it matter if I don’t care about sex?


    Well if you have a wife or girlfriend and want them kept happy you might want to consider having a PDE5 Inhibitor at least on hand. I think you should have it on hand even if you don’t care about sex during PCT or don’t plan to use it, thinking you won’t need it!

    I highly recommend having a PDE5 Inhibitor on hand during and post cycle so please do so. You might thank me later on.
    I know you do not normally see people recommending having a PDE5 on hand, but I think better safe than sorry.

    Even if you don't really need it, IT IS nice to use here and there for those that want to go for a long time or just dont feel they can stay hard as long as they want to.
    My “other half” is lucky where when she is in mood and we get to it, I get her there in about 5-10min (yah I know it is awesome, Tough Twister? lol ), then I AM the one taking forever.
    So in my case it would just piss off my GF if I took CIA or Viagra just for the hell of it.
    But there are a lot of others out there where it is the other way around and in those cases this tool could be implemented to help them out.

    Last thing you want is relationship issues when you’re already in PCT and all over the place emotionally.

    Most men still WANT to have sex anyway while recovering or even having erection issues, so not having libido probably won’t be the case for most, just improper function or softer than they would like and these tools can fix that issue.

    To use a PDE5 Inhibitor safely you should understand the compounds before using them and that doesn’t mean just knowing the dosing you were told by some guy.
    *Yes I am “some guy”, but at least I am giving you some extra info on it! ;-)


    I feel it should never be the case of “ohh I can’t get it up, I’ll just take this pill because that’s what it is for”.
    This is a reckless way to go through life!
    You should have some basic understanding of compounds BEFORE using them and have your health checked out beforehand. In my opinion that is the best way to go about it.

    I will list what I feel are the three most well-known and used PDE5 Inhibitors, with their basic compound info and then how you may incorporate them into your cycle, PCT or just daily life, safely and effectively.


    PDE5 Inhibitors:

    Vardenafil (Varden)-
    Varden is in a class of drugs called phosphodiesterase (PDE) inhibitors which treats erectile dysfunction or the inability to achieve and/or maintain an erection of the penis adequate for sexual intercourse. Varden dosing is 5-20 mg (10mg is recommended dose) one hour prior to sexual activity.

    Sildenafil Citrate (Viagra / V)-

    Viagra is also in a class of drugs called phosphodiesterase (PDE) inhibitors which treats erectile dysfunction or the inability to achieve and/or maintain an erection of the penis adequate for sexual intercourse. Half-life is about 4 hours. Dosing for Seldenafil is 25mg to 100mg (50mg is recommended dose) taken up to once per day and should be taken between 40 minutes and 4 hours prior to sex.[2]

    Tadalafil citrate (Cialis/CIA) -

    CIA is also in a class of drugs called phosphodiesterase (PDE) inhibitors which treats erectile dysfunction or the inability to achieve and/or maintain an erection of the penis adequate for sexual intercourse. But Tadalafil still requires sexual stimulation for the penis to develop an erection. Some people prefer this as they feel it works more (naturally) and the effects of one dose can be felt for up to a couple days. The half-life of Tadalafil is about 18 hours but it has about a 35 hour effectiveness widow. To be used as needed. If needed often every day to every other day dosing may be optimal or dosing some time on the day of encounter but at least 1-2 hours before encounter. Dosing is from 10mg up to 40mg (20mg is the recommended upper end of dosing)[3]. I recommend starting low until you find what works.


    CIA is a great pick if it is for one of those (uncertain) dates where you are not sure if it will be needed or not. It can still be used without having to walk around with an unwanted erection which is sometimes an issue with Viagra.

    So how will you implement this if you are an AAS user in PCT?


    I would recommend having it on hand before starting PCT and even better; before the start of the cycle! Then just use as needed.
    If you are unsure of possible sex but want to be ready for it (e.g. first dates or new friends), I feel CIA would be best the best option over the Viagra and Varden.

    For others that just want it on hand to use on the spot should sex come up, I would recommend the Viagra.
    I have heard of people mixing them, but I would not recommend that personally. I think you should just pick one and stick with it.

    A lot of times it is a mental thing and/or a hormonal thing and just having the PDE5 inhibitors on hand may help those in PCT knowing mentally they have help if needed. That would lead to less nervousness and that alone can cause the dreaded “dead/wet noodle”. (It worked for me when I used to do PCT, now I am on HRT so it’s not much of a concern and never really was an issue for me with the exception of a few off days from lack of food or other issues but it is still nice to take from time to time.)
    For me food is more like Viagra, and if I do not eat my food… well I don’t have much fun. :-(

    I would advise only relatively healthy people to use any of these compounds.

    You should be healthy and without any sort of heart or blood issues.

    I would HIGHLY recommend getting a full checkout before any AAS or PDE5 use for safety.

    If you get a green light, then move on slowly and safely.


    I think you got it but just for some eye candy here is a common cycle with a PDE5 added to the info:


    Wk1-14 Teste 500mg ew
    Wk1-12 300mg deca ew
    Wk15-19 PCT Clomi 30-70mg ed
    Wk1-16 Stane (AI) 12.5mg ed
    Wk15-22 PDE5 On hand and ready to use *I do rec having it from start just in case *


    I really hope this info helps someone out there on the topic of PDE5 inhibitors and how to use them safely. Even just for people worried about their MOJO not working post cycle or even during cycle since some have issues with deca or tren like compounds, I would have been happy to be able to help out with.

    Well hope you enjoyed!

    Feel free to PM me with any questions or opinions!


    Take care!

    :-D










    References:
    1)Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development Y. H. Jeon, Y. -S. Heo, C. M. Kim, Y. -L. Hyun and T. G. Lee, et al. Cellular and Molecular Life Sciences, 2005, Volume 62, Number 11, Pages 1198-1220 Cellular and Molecular Life Sciences, Volume 62, Number 11 - SpringerLink
    2) Erectile Dysfunction Home > Viagra Dosage Written by/reviewed by: Kristi Monson, PharmD Last reviewed by: Kristi Monson, PharmD Viagra Dosage
    3) Dosage of Tadalafil Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD Last reviewed by: Kristi Monson, PharmD Dosage of Tadalafil
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    These statements have not been evaluated by the FDA, do not constitute medical advice, and are not official or authorized comments by LG Sciences, LLC.

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    I should mention I found low dosed CIA to give GREAT pumps during workouts on top of extra umpff.
    Not sure if any one ever tried that, but its nice.
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    Excellent post
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    Viagra works by directly increasing NO
    Taking it pre workout = roadmap veins

    These are very bad drugs to take long term though
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    After blasting and cruising for over a year.. I love me some Cialis. Plus it keeps from waking up to pee thought the night.
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    After blasting and cruising for over a year.. I love me some Cialis. Plus it keeps from waking up to pee through out the night.
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    Quote Originally Posted by Zac Speed View Post
    After blasting and cruising for over a year.. I love me some Cialis. Plus it keeps from waking up to pee through out the night.
    Can you hypothesize on why? I noticed the same but never put 2+2 together.
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    Quote Originally Posted by threeFs View Post

    Can you hypothesize on why? I noticed the same but never put 2+2 together.
    I'd assume it has to do with blood flow down by the prostate but thats a wild guess..
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    Quote Originally Posted by Zac Speed View Post
    I'd assume it has to do with blood flow down by the prostate but thats a wild guess..
    thats what I was thinking also.

    also low dosed CIA is shown to help most people with high BP, long term.

    Just got like 4 more bottles of CIA and a couple Viagra bottles.
    Been loving the stuff. rarely even take a full dose.
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    I take 5mg of cialis sometimes on a Friday and blow my wife's mind until Sunday night. I am very sensitive to it and it is an ego booster. I don't have any problems, so a tiny amount can take things to a whole other level.
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    Rec dosages of cialis for every day use is 3 mg

    Works well. Last for about 2 days.

    Gives me indigestion/ heart burn

    Small price to pay for rock hard boners on demand like I'm 15 again.
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    Yep, literally on demand. It is pretty fun.
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    Quote Originally Posted by kisaj View Post
    Yep, literally on demand. It is pretty fun.
    HELLZ YEAH!!! haha, gots me a few more btls :P and a btl of V for the hell of it :$
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    My ex and I tested X and cialis back in the day. Good times until we went into the hot tub and I woke up in the morning feeling like my brain was melting.

    Side note, I feel like any sex problems on or during pct is I just don't want to have sex. If a girl plays with jay jr he still works but I don't go out of my way to make it happen. So just lack of libido but the tool still works for me.
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    Thank god for Cialis, cause after using letro, it's my new best friend! Lol
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    Quote Originally Posted by jaycuda View Post
    My ex and I tested X and cialis back in the day. Good times until we went into the hot tub and I woke up in the morning feeling like my brain was melting.

    Side note, I feel like any sex problems on or during pct is I just don't want to have sex. If a girl plays with jay jr he still works but I don't go out of my way to make it happen. So just lack of libido but the tool still works for me.
    Look into an iPT-141 (peptide) and Cia combo. the iPT should help with libido, and the Cia the flow. its a good combo for PCT for sure!
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    Viagra and any analogue of it gives me the worst headache of my entire life. I swear it's like I want to die it's so bad. Rock hard boner isn't worth that pain.

    Does anybody else experience this? How about with CIA?
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    I get it. With 3mg of cialis.

    Not as bad with that low dose.
    Two Advil takes care of it.
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    Quote Originally Posted by jbryand101b View Post
    I get it. With 3mg of cialis.

    Not as bad with that low dose.
    Two Advil takes care of it.
    Have you used both?
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    Quote Originally Posted by DonnyG View Post

    Have you used both?
    Na, I prefer cialis cause I take a 3mg dose and it last for 3-4 days.
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    Quote Originally Posted by jbryand101b View Post
    Na, I prefer cialis cause I take a 3mg dose and it last for 3-4 days.
    Too funny. We have so many people in there 20's who are able to give real life experience advice with these products.
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    Quote Originally Posted by LiveToLift View Post
    Too funny. We have so many people in there 20's who are able to give real life experience advice with these products.
    Who's in their 20's?

    I use cialis while using letro.
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    Quote Originally Posted by jbryand101b View Post
    Who's in their 20's? I use cialis while using letro.
    I must have misjudged or misread a post from you. Could have swore you were younger than 30. In any case you are definitely not old enough that someone would assume you'd need assistance.
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    Quote Originally Posted by LiveToLift View Post
    I must have misjudged or misread a post from you. Could have swore you were younger than 30. In any case you are definitely not old enough that someone would assume you'd need assistance.
    Have you ever used letrozole?
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    Quote Originally Posted by jbryand101b View Post
    Have you ever used letrozole?
    why you ask?
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    Because it makes your wang not work no matter your age.
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    Quote Originally Posted by kisaj View Post
    Because it makes your wang not work no matter your age.
    Yessss it does. Lol
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    Quote Originally Posted by kisaj View Post
    Because it makes your wang not work no matter your age.
    There is other ways of counteracting that side. Never needed to go the cialis/Viagra route hence why I asked why that question would be relevant. Then again I'm married and have no problem performing even when on deca, tren or letro. I don't need the porn star libido a single man might need.
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    That is great that you don't need to go that route, but many do. Most people I know can't take it because it crushes libido and subsequently experience ED.
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    Quote Originally Posted by kisaj View Post
    That is great that you don't need to go that route, but many do. Most people I know can't take it because it crushes libido and subsequently experience ED.
    Don't get me wrong my libido takes a hit from each of those I listed. I just prefer to combat with other supplements. That is rough that you have such a tough time with it bro.
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    Not too mention a strong test base always triumphs anything I throw in. Even on high dose NPP my test base kept me going long and strong.
    Maybe I'm just lucky
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    I appreciate the concern, but I don't take letro. I just happen to know people that do and many on this board seem to.
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    I've never seen anyone even on high dose test, still have boners from dosing (legit) letro every day .

    I'm running test and eq now, and I've ran test then added Adex or letro and it never fails to crush my libido.

    With cialis I don't even have to be in the mood, wife can give it a few tugs and have at it.

    When I'm not on cycle,pct, or fighting gyno flare ups, everything's normal.
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    Quote Originally Posted by jbryand101b View Post
    I've never seen anyone even on high dose test, still have boners from dosing (legit) letro every day . I'm running test and eq now, and I've ran test then added Adex or letro and it never fails to crush my libido. With cialis I don't even have to be in the mood, wife can give it a few tugs and have at it. When I'm not on cycle,pct, or fighting gyno flare ups, everything's normal.
    You've been injecting for a year now and I imagine have very minimal experience with letro. At least I would hope with that time length. I don't judge everything by running it one time. I've ran legit letro and still held on to libido. As I said there is other ways to combat. To think what you have "seen" is the only outcome possible is goofy to me.
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    Quote Originally Posted by LiveToLift View Post
    You've been injecting for a year now and I imagine have very minimal experience with letro. At least I would hope with that time length. I don't judge everything by running it one time. I've ran legit letro and still held on to libido. As I said there is other ways to combat. To think what you have "seen" is the only outcome possible is goofy to me.
    Uh huh. Because injecting aas is the only way one can use steroids.
    And I know nothing of the science of aas or human physiology.
    It's all a year's worth of anecdotal evidence for me.
    In fact, I just signed up.
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    Quote Originally Posted by jbryand101b View Post
    Uh huh. Because injecting aas is the only way one can use steroids.
    I would love for you to quote where I implied that please.
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    Quote Originally Posted by LiveToLift View Post
    I would love for you to quote where I implied that please.
    It's in the quotes.

    Otherwise, there is no reason to mention how long I've been injecting aas.

    As it's irrelevant.
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    I realize you have incredibly extensive PH/oral steroid use. A simple thread history search would prove that tremendously. I've been on this board along side and following many of your posts and cycles over the last 4 years but didn't remember you having to use letro so regularly. What orals resulted in such outcomes? Just being nosey.
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    Quote Originally Posted by LiveToLift View Post
    I realize you have incredibly extensive PH/oral steroid use. A simple thread history search would prove that tremendously. I've been on this board along side and following many of your posts and cycles over the last 4 years but didn't remember you having to use letro so regularly. What orals resulted in such outcomes just being nosey?
    M1t stacked with mdiene with 4-androstenediol as a base about 2 years ago. is what jumps in my mind.

    I still have leftovers from both from stopping.
    Most recently, adding 120mg of trenadione to the cycle before the Dimethadrol one.

    With letro I've found it to be my favorite simply d/t dosing allows for a bottle to last a long time. 2.5mg is always too much. 1.25 is usually the highest I can tolerate for about a week.
    .625mg e/o/d I've found is a great value in pct.
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    Quote Originally Posted by jbryand101b View Post
    M1t stacked with mdiene with 4-androstenediol as a base about 2 years ago. is what jumps in my mind. I still have leftovers from both from stopping. Most recently, adding 120mg of trenadione to the cycle before the Dimethadrol one.
    I forget the level of oral cycles you run. Would you say you use letro as precaution or only if needed? I know I tend to get paranoid and often throw it in as precaution over actually being necessary. I finally got my mind state off over use now but at one time used letro every cycle simply because I am prone to sides.
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