Originally Posted by
KenTheEagle
I dont see wheres the bad advice man, can you point em with facts? you know, i really dont care what you know and lastly, is your liver and the OPs liver, not mine... but i will educate you a lil bit, i personally like to research before taking something....
The use of the antiestrogen tamoxifen (TAM) is associated with an increase in endometrial cancer. TAM-induced endometrial carcinogenesis may proceed through a genotoxin-mediated pathway, although the detection of endometrial TAM-DNA adducts in exposed women is still controversial. In this study, a monkey model has been used to investigate the question of TAM-DNA adduct formation in primates. Two methods have been used to determine TAM-DNA adducts: a TAM-DNA chemiluminescence immunoassay (TAM-DNA CIA), using an antiserum that has specificity for (E)-α-(deoxyguanosin-N2-yl)-tamoxifen (dG-TAM) and (E)-α-(deoxyguanosin-N2-yl)-N-desmethyltamoxifen (dG-desmethyl-TAM) and electrospray ionization tandem mass spectrometry (ES-MS/MS) coupled with on-line sample preparation and high-performance liquid chromatography (HPLC). Mature (19 year old) cynomolgus monkeys were given either vehicle control (n = 1) or TAM (n = 3) twice daily for a total dose of 2 mg of TAM/kg body weight (bw)/day for 30 days by naso-gastric intubation. Tissues were harvested, and DNA was isolated from uterus, ovary, liver, brain cortex, and kidney. By TAM-DNA CIA, values for uterine TAM-DNA adducts in two monkeys were 0.9 and 1.7 adducts/108 nucleotides, whereas values for ovarian TAM-DNA adducts in the same animals were 0.4 and 0.5 adducts/108 nucleotides. Liver, brain cortex, and kidney DNA samples from the three exposed monkeys had TAM-DNA levels of 2.1–4.2 adducts/108 nucleotides, 0.4–5.0 adducts/108 nucleotides, and 0.7–2.1 adducts/108 nucleotides, respectively. By HPLC-ES-MS/MS, the levels of TAM-DNA adducts detected in all tissues were comparable with those observed by TAM-DNA CIA. Thus, values for uterine TAM-DNA adducts ranged from 0.5 to 1.4 adducts/108 nucleotides, whereas values for ovarian TAM-DNA adducts, measurable in two monkeys, were 0.2 and 0.3 adducts/108 nucleotides. Liver DNA contained the highest TAM-DNA adduct levels (7.0–11.1 adducts/108 nucleotides), whereas brain cortex DNA contained lower adduct levels (0.6–4.8 adducts/108 nucleotides) and the lowest levels were measured in the kidney (0.2–0.4 adducts/108 nucleotides). This study indicates that cynomolgus monkeys are capable of metabolizing TAM to genotoxic intermediates that form TAM-DNA adducts in multiple tissues.
now if you DO RESEARCH, youll find plenty of studies of tamoxifen... and then that clomid and torem are WAY safer........... as i said, I DONT CARE and sorry for giving advice.... now my advice was PROPER DOSAGE OF HALODROL and what i know about tamoxifen.... so, where is the bad advice?
good luck with your runs man.