New SARM GW-501516

[schwellington]

anyone heard of this? I came across it on a Reaserch Chem site (which is extremely reputable) and this is a SARM i have never come across before- sounds somewhat similar to ostarine

here is the write up


FOR RESEARCH PURPOSES ONLY NOT FOR HUMAN CONSUMPTION

GW-501516
(also known as GW-501,516,GW1516 or GSK-516) is a PPAR***948; modulator compound being investigated for drug use by GlaxoSmithKline.[1][2] It activates the same pathways activated through exercise, including PPAR***948; and AMP-activated protein kinase. It is being investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. [3] [4] GW-501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone. [5][6]

GW-50156 regulates fat burning through a number of widespread mechanisms [7]; it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization.,[8][9] [10] This shift changes the body's metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. [11] GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity [12]

It has been demonstrated at oral doses of 5 mg a day to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation.[13] Treatments with GW-501516 have been shown to increase HDL cholesterol by up to 79% in rhesus monkeys and the compound is now undergoing Phase II trials to improve HDL cholesterol in humans. [14]

Concerns were raised prior to the 2008 Beijing Olympics that GW-501516 could be used by athletes as a performance enhancing drug which was not currently controlled by regulations or detected by standard tests. One of the main researchers from the study on enhanced endurance consequently developed a urine test to detect the drug, and made it available to the International Olympic Committee.[15] The World Anti-Doping Agency has also begun work on a test GW-501516 and other related PPAR***948; modulators.,[16] and they have been added to the prohibited list from 2009 onwards.[17] The compound has yet to be named a controlled or prohibited substance by any nation's drug enforcement or regulation agency. To date, no athlete is known to have tested positive for the substance, though the increase in endurance, muscle fiber performance, fat loss and metabolism suggests GW-501516 has the potential for ergogenic use and abuse.

[mattrag]

Subbed for more info.

[SweetLou321]

interesting

[mattrag]

Pat talked about this over at his forum. Said the stuff is great for endurance but horrible for strength.

[pumpga]

It has been getting great reviews at least one other board. Results starting almost immediately. No sides noticed by reviewers though I haven't seen anyone post bloodwork.

[sethroberts]

This is not a SARM. It is a PPAR delta agonist not an androgen. Pat is right. good for endurance, will probably lower cholesterol but no evidence that I know of for anabolic action.

[mattrag]

It has been getting great reviews at least one other board. Results starting almost immediately. No sides noticed by reviewers though I haven't seen anyone post bloodwork.

Hmmm. Anyone report on suppression/dosing?
I can it being used on a hardening routine with very good results.

[schwellington]

This is not a SARM. It is a PPAR delta agonist not an androgen. Pat is right. good for endurance, will probably lower cholesterol but no evidence that I know of for anabolic action.

funny the site is selling it under SARMs catagory. I have always had good interactions with these guys so maybe they are mistaken. it says that it regulates glucose uptake, and helps with fat oxidation- i am insulin resistant- so this would help me lean out perhaps?

[sethroberts]

Like most people in this industry (supps, research chems) they either don't know what they are talking about or are deliberately lieing to sell more product. It doesn't take a science degree to buy raw materials from china, package them and sell them.

[mattrag]

Any studies or blood work on how suppressive PPARs are?
And uses?

[schwellington]

seth can you chime in about how this PPAR might help me reduce bodyfat via increased glucose uptake and fat oxidation? I am insulin resitant- just how effective would this product be?

[pumpga]

Hmmm. Anyone report on suppression/dosing?
I can it being used on a hardening routine with very good results.

Dosing was 10mg, nothing about suppression. It was an Ostarine and GW501516 cycle. Reviewer was seeing some gains while leaning out with increase in endurance.

[sethroberts]

I honestly don't know. It was originally researched to reduce cholesterol and reduce body weight. It was effective in these regards but I know there were concerns at the time (2002 or so) that it might promote tumor growth.

[Whacked]

It's the no-work fat loss from the PPAR-beta agonism that makes it appealing for bbers

This is not a SARM. It is a PPAR delta agonist not an androgen. Pat is right. good for endurance, will probably lower cholesterol but no evidence that I know of for anabolic action.

[Whacked]

The guy I saw was using 5 mg and lost a decent amount of fat. He was not fat to begin with. He ramped up to 7.5 mg and it became very uncomfortable with respect to sweating/body heat.

Dosing was 10mg, nothing about suppression. It was an Ostarine and GW501516 cycle. Reviewer was seeing some gains while leaning out with increase in endurance.

[sethroberts]

It's the no-work fat loss from the PPAR-beta agonism that makes it appealing for bbers

Thanks for the education

[mattrag]

The guy I saw was using 5 mg and lost a decent amount of fat. He was not fat to begin with. He ramped up to 7.5 mg and it became very uncomfortable with respect to sweating/body heat.

Wow. Super interesting. Did he mention what other sides and sups he was on?

[Whacked]

Seth: I smell sacrcasm. LOL

This drug is is gaining a rep as an endurance enthusiast's dream drug (as you also pointed out). I was merely letting the viewers know WHY this drug has is appealing for aesthetic reasons as well based on your earlier response:

I honestly don't know. It was originally researched to reduce cholesterol and reduce body weight. It was effective in these regards but I know there were concerns at the time (2002 or so) that it might promote tumor growth.

[Whacked]

No sides until he ramped it up to 7.5 mg (from 5mg/day)

At the increased dosing schedule, increased sweat was alll that I recall him noting

That said, I wouldnt trust this stuff just yet

Let the dust settle and be sure to get in a copious dose of PPAR-alpha supps (fish and sesamin) which impart some fat loss in addition to havign other health benefits.

Wow. Super interesting. Did he mention what other sides and sups he was on?

[mattrag]

Unless I was getting frequent bloods and other health parameter checks I wouldn't take this just yet. I'd rather know what sides to look for than learn of the sides.
Thanks for your insight!