New SARM GW-501516

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  1. New SARM GW-501516


    anyone heard of this? I came across it on a Reaserch Chem site (which is extremely reputable) and this is a SARM i have never come across before- sounds somewhat similar to ostarine

    here is the write up


    FOR RESEARCH PURPOSES ONLY NOT FOR HUMAN CONSUMPTION

    GW-501516
    (also known as GW-501,516,GW1516 or GSK-516) is a PPAR***948; modulator compound being investigated for drug use by GlaxoSmithKline.[1][2] It activates the same pathways activated through exercise, including PPAR***948; and AMP-activated protein kinase. It is being investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. [3] [4] GW-501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone. [5][6]

    GW-50156 regulates fat burning through a number of widespread mechanisms [7]; it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization.,[8][9] [10] This shift changes the body's metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. [11] GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity [12]

    It has been demonstrated at oral doses of 5 mg a day to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation.[13] Treatments with GW-501516 have been shown to increase HDL cholesterol by up to 79% in rhesus monkeys and the compound is now undergoing Phase II trials to improve HDL cholesterol in humans. [14]

    Concerns were raised prior to the 2008 Beijing Olympics that GW-501516 could be used by athletes as a performance enhancing drug which was not currently controlled by regulations or detected by standard tests. One of the main researchers from the study on enhanced endurance consequently developed a urine test to detect the drug, and made it available to the International Olympic Committee.[15] The World Anti-Doping Agency has also begun work on a test GW-501516 and other related PPAR***948; modulators.,[16] and they have been added to the prohibited list from 2009 onwards.[17] The compound has yet to be named a controlled or prohibited substance by any nation's drug enforcement or regulation agency. To date, no athlete is known to have tested positive for the substance, though the increase in endurance, muscle fiber performance, fat loss and metabolism suggests GW-501516 has the potential for ergogenic use and abuse.
    Test e/dbol/epi/winnie
    http://anabolicminds.com/forum/cycle-info/164764-schwellington-has-been.html


  2. Subbed for more info.
    RecoverBro ELITE
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  3. interesting

  4. Pat talked about this over at his forum. Said the stuff is great for endurance but horrible for strength.
    RecoverBro ELITE

  5. It has been getting great reviews at least one other board. Results starting almost immediately. No sides noticed by reviewers though I haven't seen anyone post bloodwork.
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  6. This is not a SARM. It is a PPAR delta agonist not an androgen. Pat is right. good for endurance, will probably lower cholesterol but no evidence that I know of for anabolic action.

  7. Quote Originally Posted by pumpga
    It has been getting great reviews at least one other board. Results starting almost immediately. No sides noticed by reviewers though I haven't seen anyone post bloodwork.
    Hmmm. Anyone report on suppression/dosing?
    I can it being used on a hardening routine with very good results.
    RecoverBro ELITE

  8. Quote Originally Posted by sethroberts View Post
    This is not a SARM. It is a PPAR delta agonist not an androgen. Pat is right. good for endurance, will probably lower cholesterol but no evidence that I know of for anabolic action.
    funny the site is selling it under SARMs catagory. I have always had good interactions with these guys so maybe they are mistaken. it says that it regulates glucose uptake, and helps with fat oxidation- i am insulin resistant- so this would help me lean out perhaps?
    Test e/dbol/epi/winnie
    http://anabolicminds.com/forum/cycle-info/164764-schwellington-has-been.html

  9. Like most people in this industry (supps, research chems) they either don't know what they are talking about or are deliberately lieing to sell more product. It doesn't take a science degree to buy raw materials from china, package them and sell them.

  10. Any studies or blood work on how suppressive PPARs are?
    And uses?
    RecoverBro ELITE

  11. seth can you chime in about how this PPAR might help me reduce bodyfat via increased glucose uptake and fat oxidation? I am insulin resitant- just how effective would this product be?
    Test e/dbol/epi/winnie
    http://anabolicminds.com/forum/cycle-info/164764-schwellington-has-been.html

  12. Quote Originally Posted by mattrag View Post
    Hmmm. Anyone report on suppression/dosing?
    I can it being used on a hardening routine with very good results.
    Dosing was 10mg, nothing about suppression. It was an Ostarine and GW501516 cycle. Reviewer was seeing some gains while leaning out with increase in endurance.

  13. I honestly don't know. It was originally researched to reduce cholesterol and reduce body weight. It was effective in these regards but I know there were concerns at the time (2002 or so) that it might promote tumor growth.

  14. It's the no-work fat loss from the PPAR-beta agonism that makes it appealing for bbers


    Quote Originally Posted by sethroberts View Post
    This is not a SARM. It is a PPAR delta agonist not an androgen. Pat is right. good for endurance, will probably lower cholesterol but no evidence that I know of for anabolic action.
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
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  15. The guy I saw was using 5 mg and lost a decent amount of fat. He was not fat to begin with. He ramped up to 7.5 mg and it became very uncomfortable with respect to sweating/body heat.

    Quote Originally Posted by pumpga View Post
    Dosing was 10mg, nothing about suppression. It was an Ostarine and GW501516 cycle. Reviewer was seeing some gains while leaning out with increase in endurance.
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7
  16. Cool


    Quote Originally Posted by Whacked View Post
    It's the no-work fat loss from the PPAR-beta agonism that makes it appealing for bbers
    Thanks for the education

  17. Quote Originally Posted by Whacked
    The guy I saw was using 5 mg and lost a decent amount of fat. He was not fat to begin with. He ramped up to 7.5 mg and it became very uncomfortable with respect to sweating/body heat.
    Wow. Super interesting. Did he mention what other sides and sups he was on?
    RecoverBro ELITE

  18. Seth: I smell sacrcasm. LOL

    This drug is is gaining a rep as an endurance enthusiast's dream drug (as you also pointed out). I was merely letting the viewers know WHY this drug has is appealing for aesthetic reasons as well based on your earlier response:

    Quote Originally Posted by sethroberts View Post
    I honestly don't know. It was originally researched to reduce cholesterol and reduce body weight. It was effective in these regards but I know there were concerns at the time (2002 or so) that it might promote tumor growth.
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7

  19. No sides until he ramped it up to 7.5 mg (from 5mg/day)

    At the increased dosing schedule, increased sweat was alll that I recall him noting

    That said, I wouldnt trust this stuff just yet

    Let the dust settle and be sure to get in a copious dose of PPAR-alpha supps (fish and sesamin) which impart some fat loss in addition to havign other health benefits.

    Quote Originally Posted by mattrag View Post
    Wow. Super interesting. Did he mention what other sides and sups he was on?
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7

  20. Unless I was getting frequent bloods and other health parameter checks I wouldn't take this just yet. I'd rather know what sides to look for than learn of the sides.
    Thanks for your insight!
    RecoverBro ELITE

  21. Good discussion here. More things coming out every day it seems (how legit or useful or safe they are is obviously suspect).
    Head Purus Labs Rep
    www.Puruslabs.net

  22. I concur

    Quote Originally Posted by mattrag View Post
    Unless I was getting frequent bloods and other health parameter checks I wouldn't take this just yet. I'd rather know what sides to look for than learn of the sides.
    Thanks for your insight!
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7

  23. so what exactly does this do? Matty, would this be suitable for me bro? you know what my goals
    ...::: Olympus Labs Athlete & Representative :::...
    Crossfit - DEMIGOD -

  24. Quote Originally Posted by runner_79 View Post
    so what exactly does this do? Matty, would this be suitable for me bro? you know what my goals
    Hmm, I really dont know. If this thing could do what it did w/o any adverse effects it'd be basically cardio in a bottle it seems. PPAR b-agonist. Kinda scared though... not enough research or people using it to tell for sure if it is "safe" to use.
    RecoverBro ELITE

  25. Yeah. My Aussie supplier has a few bottles.
    Also has mdrol clone...hmmmm interested in mdrol clone called super mass

    What about d-zine(co. That makes forged burner)
    ...::: Olympus Labs Athlete & Representative :::...
    Crossfit - DEMIGOD -

  26. I'd like to hear more on this. In for more discussion
    Recoverbro Elite
    "This is what we've been working on"

  27. Activation of nuclear hormone receptor peroxisome proliferator***8211;activated receptor-***948; accelerates intestinal adenoma growth

    Rajnish A Gupta1, Dingzhi Wang1, Sharada Katkuri1, Haibin Wang2, Sudhansu K Dey2 & Raymond N DuBois1,2,3

    Abstract

    We treated Apcmin mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator***8211;activated receptor-***948; (PPAR-***948. Exposure of Apcmin mice to the PPAR-***948; ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-***948; activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-***948; in the regulation of intestinal adenoma growth.

    This link has more information: carcin.oxfordjournals.org/content/28/12/2641.full
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7

  28. Intestinal polyps aren't anything I want LOL
    Quote Originally Posted by alwaysgaining View Post
    I've also done fasting and doseing and felt grealt anabolicness , deffint hunger but I'm stronger than that keep full and vascular and strength gose up
    http://anabolicminds.com/forum/cycle-info/177245-swollen87s-training-log.html

  29. Quote Originally Posted by swollen87
    Intestinal polyps aren't anything I want LOL
    Yea for sure.
    Looks like this compound I will avoid.
    RecoverBro ELITE

  30. i might have rushed this purchase a bit. i got an email saying half off at a certain site, so i checked it out expecting to get a bottle of s-4 for cheap, but then i saw this and read up a bit on it. ended buying a bottle of it but now im thinking i shouldnt have. intestinal polyps sound very un-fun. then again, that was with rats that were predisposed to intestinal polyps.
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