Interesting article on testosterone + letrozole

ahnold99

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In doing some research for my gym's nutritionist, I found an interesting article on the combination of letrozole (an aromatase inhibitor) and testestosterone in puberty delayed boys. The article states the following:

"A total of 23 boys with constitutional delay of puberty (CDP) received a conventional, low-dose testosterone treatment for inducing progression of puberty. Eleven of these 23 boys were randomized to receive a specific and potent P450-aromatase inhibitor, letrozole, for suppression of estrogen action, and 12 boys were randomized to receive placebo. Estradiol concentrations in the letrozole-treated boys remained at the pretreatment level during the administration of letrozole, whereas the concentrations increased during the treatment with testosterone alone and during spontaneous progression of puberty. Testosterone concentrations increased in all groups, but during the letrozole treatment, the increase was more than fivefold higher than in the group treated with testosterone alone." Steriodal Biochemistry and Molecular Biology, Dunkel, L., Wickman, S., 86: 345 (2003) (note, this is a peer reviewed journal, not a junk science journal)

It appears that inhibiting aromatization of testosterone keeps the testosterone in circulation longer and should lead to more androgenic effects. In the article, the boys who received test + letrozole grew 5.1 cm, but the boys who received only test or placebo didn't grow at all. Has anyone tried adding aromatase inhibitors throughout their cycles (letrozole, formestane, arimidex, but not nolvadex (tamoxifen))?

What do ya think??
 

Flash

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It appears that inhibiting aromatization of testosterone keeps the testosterone in circulation longer and should lead to more androgenic effects.
It has more to do with competitive aromatization. The letrozle binds to the aromatse enzyme and allows more test to be available, but that is not the same as extending the duration of its action. Its actually increasing the amount of active test.

Thats why you would use it post cycle. Whatever test your making would be, by this study, ~5x higher than if not.
 

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