It's really overdramatized IMO. There is an acute hyperglycemic effect upon GH administration, which is followed by a period of insulin-like effects due to, you guessed it, IGF-1. The long term potential for increased insulin resistance is real, but far too much overplayed. it does occur with those using GH for cachexia or AIDS wasting, where high doses are used for long durations. I've been on GH for about 1,5 yrs straight (and before that too), and I measure BG often due to insulin use too. My BG hasn't fluctuated at the same daily points since starting GH, indicative of no increased insulin resistance. My doses are 4-5IU/day