fieyaa
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Just a random thought that crossed my mind the other day.
I've always heard that estrogen is raised during times of alcohol consumption but never saw any studies to confirm this. An easy pubmed search produced tons of evidence for this.. ie:
Also, does one have to worry about liver toxicity with tamoxifen and alcohol? I found this study but i doubt not all of us are menopausal women
I've always heard that estrogen is raised during times of alcohol consumption but never saw any studies to confirm this. An easy pubmed search produced tons of evidence for this.. ie:
Anyways, I never drink during the weekdays (which is hard being 21 and living on campus at the #3 party school in the us) but was wondering if selective estrogen receptor modulators, like tamoxifen, would help reduce the increasing endogenous estrogen levels during times of alcohol consumption like on the weekends if one were to binge drink or even have a few beers? Im guessing there is a difference between estrogen levels if one had 2 beers to another person who consumed 12 beers, but, nevertheless, would taking a certain dosage of tamoxifen reduce these levels?Does diet affect breast cancer risk?
Holmes MD, Willett WC.
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA. [email protected]
The role of specific dietary factors in breast cancer causation is not completely resolved. Results from prospective studies do not support the concept that fat intake in middle life has a major relation to breast cancer risk. However, weight gain in middle life contributes substantially to breast cancer risk. Alcohol is the best established dietary risk factor, probably by increasing endogenous estrogen levels. Hypotheses relating diet during youth to risk decades later will be difficult to test. Nevertheless, available evidence is strong that breast cancer risk can be reduced by avoiding weight gain during adult years, and by limiting alcohol consumption.
PMID: 15217490 [PubMed - in process]
Also, does one have to worry about liver toxicity with tamoxifen and alcohol? I found this study but i doubt not all of us are menopausal women
Sorry if this is a dumb question... Any help or feedback would be appreciated..Blood chemistry profiles in menopausal women administered tamoxifen for breast caocer.
Lox C, Ronaghan C, Cobos E.
Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
1. Menopausal controls not administered estrogen replacement therapy (ERT), or menopausal women taking 10 mg of tamoxifen bid had serum samples collected. 2. When controls were compared to treatment, significant elevations in the TRI (triglycerides), SGOT (serum glutamic oxalacetic transaminase), SGPT (serum glutamic pyruvic transaminase) and the GGT (gamma gluteryl transferase) were found in the tamoxifen group. Liver enzymes were elevated but still within the normal range for the tamoxifen-treated group. 3. The results from this study suggest that the use of tamoxifen citrate for adjuvant therapy in women with breast cancer causes no major alterations in the blood chemistry of menopausal women. The elevations observed were still within the normal ranges of menopausal women with the exception of the triglycerides.
PMID: 9457492 [PubMed - indexed for MEDLINE]