How to take Boladrol

Page 2 of 2 First 12

  1. if you guys don't start talking english here i am going to post in Italian!


  2. im looking into some info of methyl 1,4-androstenediol (m14add) possibly being able to convert into estrogen via a non enzymatic reaction. (according to pa, this may be possible)

    not sure if this would also pertain to all diols, like boladrol. 1,4ad seems to be different in how it would need to be converted. I think.

    It's so complex, and I can access the paper pa told me to read.
    •   
       


  3. Quote Originally Posted by jbryand101b View Post
    im looking into some info of methyl 1,4-androstenediol (m14add) possibly being able to convert into estrogen via a non enzymatic reaction. (according to pa, this may be possible)

    not sure if this would also pertain to all diols, like boladrol. 1,4ad seems to be different in how it would need to be converted. I think.

    It's so complex, and I can access the paper pa told me to read.
    I saw he posted that. M14ADD looks like it would have trouble making the conversion to Dianabol. It has to gain a hydroxylation somehow and then dehydrate before it can make that conversion right? Is that via the 3b-HSD pathway or another enzyme pa is talking about because I always thought 17a-methyl-1,4-androstadiene-3b,17b-diol + 3b-HSD = 17a-methyl-1,4-androstadiene-3-one-17b-ol
    Serious Nutrition Solutions Representative

  4. Quote Originally Posted by Bry17 View Post
    This would, theoretically, mean that boladrol doesn't convert to Bolasterone at a high rate because many users are experiencing, like myself, lean gains. So if bolasterone has a higher estrogen conversion than Dianabol and M14ADD has a higher estrogen conversion than Boladrol then something must be interfering with Boladrol's conversion because Boladrol should aromatize at a higher rate than M14ADD.. see what i'm saying?

    I've heard this information before so I know you're right.
    No-one's said that bolasterone has a higher estrogen conversion than dianabol.

    Quote Originally Posted by jbryand101b View Post
    well, it has been suggested in a paper that bolasterone's conversion into methyl estradiol is significantly less than that of methyl testosterone, which is just one less methyl (the 7a).

    7a methylation greatly changes the compound, in the same sense that adding a 17a methyl changes a compound.

    for example, boldenone has less aromatization than testosterone, but add a 17a methyl, and (now dianabol) has a higher rate or aromatization, also into a more potent estrogen.

    so it is most likely the 7a methylation that changes up the compound in this way, as well as many others.

    bolasterone's estrogen conversion would be more potent than dianabols, because of the extra 7a methylation, but this is also what is suggested to cause it's estrogen conversion to be so much less than that of methyl testosterone.

    remember "more potent" and "the rate of estrogen conversion" are two different things, which bolasterone seems to have lowered conversion into estrogen, but that the estrogen converted will just hang around longer.

    Do you have any evidence that dianabol aromatises more readily than boldenone?

    Quote Originally Posted by Bry17 View Post
    This is talking about estrogen receptor affinity right? Is this the conclusion as to why it reduces affinity or just one of the reasons?

    The point of 7 alkylation is to reduce the 5a-reductase enzyme, but it seems this change has effected potency of the compound and aromatization.
    It's not talking about ER affinity. It's talking about the affinity of the compound for binding to the aromatase enzyme.

    7a-alkylation doesn't "reduce the 5a-reductase enzyme". 7a-alkylation prevents 5a-reduction (but not 5b-reduction), as well as having other effects such as flattening the molecule, increasing AR affinity, and may also reduce aromatisation.

    Quote Originally Posted by Bry17 View Post
    I always thought 17a-methyl-1,4-androstadiene-3b,17b-diol + 3b-HSD = 17a-methyl-1,4-androstadiene-3-one-17b-ol
    That's always been the assumption.

  5. Quote Originally Posted by henryv View Post
    Do you have any evidence that dianabol aromatises more readily than boldenone?
    Of course not, I am probably committing the same error I accuse people of doing, in mixing up the potency of methyl estrogen vs estrogen & rate of aromatization.

    I can always count on you to correct me an open my eyes.
    •   
       


  6. Two excerpts from the text jbry posted that really stuck out at me..

    7-alkyltestosterone derivatives were tested and were found to lose androgenic and anabolic activity rapidly as the size of the group at the C-7 position increased.
    What does it mean by "as the size of group at C-7 position increased?" What causes this size increase? ; as this excerpt makes it sound like this "size increase" of the carbon molecule at the 7th position is what's responsible for Bolasterone's and Calusterone's A/A ratio (or any 7a for that matter)
    7-methylation of 19-nor androgens with a 17-methyl group causes a many fold increase in androgenicity due to a sufficient protection of the 17-methyl group that permits delivery of the highly active 19-nor steroid to the end organ
    ^One can only imagine how suppressive ment-dione will be. Good lord. 7a methylation, according to this text, only increases androgenicity in a 19 nor derivative like ment-dione.. ~ EDIT: NVM, it says only if it has a 17a methylation, so disregard this one
    Serious Nutrition Solutions Representative

  7. Quote Originally Posted by Bry17 View Post
    Two excerpts from the text jbry posted that really stuck out at me..

    What does it mean by "as the size of group at C-7 position increased?" What causes this size increase? ; as this excerpt makes it sound like this "size increase" of the carbon molecule at the 7th position is what's responsible for Bolasterone's and Calusterone's A/A ratio (or any 7a for that matter)
    They tested a number of 7a-alkylated testosterone derivatives with different 7a-substituents. They found that smaller functional groups (like a methyl group) caused a significant increase in anabolic and androgenic activity, but the larger the substituent, the less anabolic and androgenic activity was seen.

  8. Quote Originally Posted by henryv View Post
    They tested a number of 7a-alkylated testosterone derivatives with different 7a-substituents. They found that smaller functional groups (like a methyl group) caused a significant increase in anabolic and androgenic activity, but the larger the substituent, the less anabolic and androgenic activity was seen.


    The substitution at the 7-position with a cyano or
    acetylthio moiety resulted in lower binding affinity and decreased
    biological activity compared to the 7-methyl substitution
    Oh duh, somehow I missed this part of the paper. So basically that means methyl substitution was the most prudent in comparison to a cyano group and the others that were tested (does not surprise me, it's always a methyl lmao). But how would that relate to size? Is a cyano larger than a methyl group or something?
    Serious Nutrition Solutions Representative

  9. Quote Originally Posted by Bry17 View Post
    Oh duh, somehow I missed this part of the paper. So basically that means methyl substitution was the most prudent in comparison to a cyano group and the others that were tested (does not surprise me, it's always a methyl lmao). But how would that relate to size? Is a cyano larger than a methyl group or something?
    A methyl group is a small functional group. This is why it is used at 17a. Its existence prevents the 17b-ol from becoming a 17-one, but it is small enough not to impair receptor binding. The same is true of the 7a position - a methyl group here imparts a number of positive receptor binding effects that larger substituents do not.

    The paper it is referring to does not study bolasterone specifically, or a testosterone derivative with a 7a cyano group.

  10. so far it is looking like boladrol dosage should be dosed between 8-10mg

  11. Quote Originally Posted by henryv View Post
    A methyl group is a small functional group. This is why it is used at 17a. Its existence prevents the 17b-ol from becoming a 17-one, but it is small enough not to impair receptor binding. The same is true of the 7a position - a methyl group here imparts a number of positive receptor binding effects that larger substituents do not.

    The paper it is referring to does not study bolasterone specifically, or a testosterone derivative with a 7a cyano group.
    Ok thanks henry, yeah I knew it wasn't talking about anything specific I just drew conclusions from its context.
    Serious Nutrition Solutions Representative

  12. Quote Originally Posted by IBE View Post
    so far it is looking like boladrol dosage should be dosed between 8-10mg
    It would seem that way. It would've been more consumer friendly to make the tablets 3-4mg, At 8 mg I could feel it in full swing and leaned out nicely
    Serious Nutrition Solutions Representative

  13. the next run will be 3 or 4mg per tablet we still did not make out minds up yet..lol

  14. hmmm........... ree-hee-hee-heelyyyy.....

  15. Quote Originally Posted by IBE View Post
    so far it is looking like boladrol dosage should be dosed between 8-10mg
    Split into 2 equal AM and PM doses?

  16. Quote Originally Posted by IBE View Post
    the next run will be 3 or 4mg per tablet we still did not make out minds up yet..lol
    Interesting.
    PHF Rep


  17. Boladrol is in tablet form and not a capped pill correct?

  18. Quote Originally Posted by Chubbinmuffin View Post
    Boladrol is in tablet form and not a capped pill correct?
    Correct

  19. Thanks. How big are the tabs? Just wondering if I could easily split them

  20. Quote Originally Posted by Chubbinmuffin View Post
    Thanks. How big are the tabs? Just wondering if I could easily split them
    Don't split them, they are incredibly small
    Serious Nutrition Solutions Representative

  21. They are only 2mg of Boladrol per. According to the IBE rep, they are upping the recommended dosage to 8-10mg. No reason to split a 2mg anyway.

  22. Quote Originally Posted by Chubbinmuffin View Post
    Thanks. How big are the tabs? Just wondering if I could easily split them
    It's like the size of an Aspirin. And there is no reason to take 1 mg of Boladrol.

  23. I know. In case they do up the dosage.

  24. hmm. i might be picking up another packet of bola and running it at 6 - 8 mg per day then when my next cycle comes around in august or september.

  25. I may have to start my Boladrol run on Monday, Im getting antsy!!


    Trust in the LORD with all your heart, And lean not on your own understanding; In all your ways acknowledge Him, And He shall direct your paths . Proverbs 3:5-6
  •   

      
     

Similar Forum Threads

  1. Boladrol PCT (Please help!)
    By Spidersilva in forum Post Cycle Therapy
    Replies: 4
    Last Post: 05-25-2011, 09:13 PM
  2. boladrol and S4?
    By the GUNSHOW in forum Anabolics
    Replies: 2
    Last Post: 05-02-2011, 09:32 AM
  3. Is BOLADROL a Must-Have ??
    By eXinCe in forum Anabolics
    Replies: 36
    Last Post: 12-09-2010, 08:05 PM
  4. Boladrol + Epi?
    By Smith402 in forum Anabolics
    Replies: 4
    Last Post: 11-20-2010, 03:05 PM
  5. eta on boladrol ? anybody !
    By WATERLOGGED in forum Anabolics
    Replies: 11
    Last Post: 11-19-2010, 02:53 PM
Log in
Log in