I have been using Dermacrine for the first time during cycle to help with lethargy/libido. I started noticing its effects around week 2-3. Lethargy became almost non-existant and libido increased a good bit. I know I am shutdown quite a bit, but certainly don't feel that way due to the Dermacrine. I have run 2 cycles before without derm and this one is definitely the best so far.
Not sure about it holding on to gains since I'm not quite done with it yet.