I used 4AD from kilosports, my t/d formula was a pre-application of dmso (pre-fab cream with aloe, etc.) on the skin, then followed with 300mg 4AD mixed in instant hand sanitizer (made of ethyl alcohol, isopropyl alcohol, glycerin, propelyne glycol). Its basically the same as any prime t/d formula but a hell of a lot cheaper. I'm sure someone will find something wrong with this, but in my mind it works great. So I'd do 2 daily applications 12 hours or so apart, 300mg each. I took the M1T in the am, because it didn't seem to make me lethargic. If it had, I would have taken it with my last meal.