AAS and the Adrenal Gland (Seth Roberts' views requested)
- 06-19-2010, 06:26 PM
AAS and the Adrenal Gland (Seth Roberts' views requested)
A poster here had asked how long one should wait between cycles, and I recall Seth Roberts responding that it depends on when the adrenal function will return to normal following a cycle. Unfortunately I cannot find the thread and may be slightly misquoting him, though I think this is pretty much what he said even if not verbatim.
Can Seth and others please comment more on this? The normalization of Adrenal Functions following cessation of AAS is something people almost never talk about on this board. Everyone is focusing on returning testical function back to normal, but the adrenal axis is perhaps fully ignored. Thus, any input would be highly welcome. What aspect of adrenal function is disturbed with AAS? Is it cortisol production? What can be done to return it back to normal as fast as possible...?
- 06-19-2010, 06:45 PM
06-19-2010, 07:00 PM
06-19-2010, 09:20 PM
Is there anything at all that you suggest people do (in addition to not megadosing). I know that it is very hard to make blanket statements, because these drugs could affect people to differently, but anything at all that applies in general?
Would the so-called adaptogens be an option? Supposedly they can increase outputs of certain hormones/neurotransmitters if they are low and decrease them if they are high, thus always bringing an individual closer to a balance (though I doubt they often work as such)...
I agree blood work is always good, but in reality it is so hard to test for everything. Things like cortisol are not even easy to test for from the blood and require 24 hour urine collection...
06-19-2010, 11:24 PM
not from the research studies i've read they get it from the blood pretty easily.
not trying to start an argument, just saying...
06-20-2010, 01:38 AM
Of course you will read it from a blood sample easily. The trouble is that cortisol fluctuates a huge amount during the day; typically the morning readings are 300% of early afternoon readings. Thus, a single reading will give you very little information. That is the reason cortisol is usually measured in 24 hour urine collection tests. Research studies that aim to look at a short-term change at serum cortisol will do fine with a single reading (you give the person an injection of a drug and take their blood right away). But for a more complete assessment, a 24 hour reading is usually needed.
06-20-2010, 02:56 AM
Seth (and Other Members),
What would you say about the potential of different DS/PHs to elevate red blood cell count? Is Superdrol again the most potent in this regard, and thus most likely to lead to polycythemia? (and what PH is safest in this regard) Also, anything that can be done to reduce the chance of polycythemia during aas use?
Thanks a ton for the valuable input...
06-20-2010, 09:54 AM
06-20-2010, 10:35 AM
http://www.ncbi.nlm.nih.gov/pmc/arti...0/?tool=pubmed) as does nandrolone (http://www.ncbi.nlm.nih.gov/pubmed/10649731).
This study actually showed nandrolone to be the most potent (http://www.ncbi.nlm.nih.gov/pubmed/4732322) while this paper says DHT (http://bloodjournal.hematologylibrar...eprint/43/1/39).
In any cas, it appears that most, if not all AAS elicit some positive response on red blood cell production. The comparative evidence is relatively thin so the bros who state emphatically that equipoise or anadrol or "insert steroid here" is the best at reasing red blood cells are just parroting good old bro-lore. All of that being said, it is likely that the DS/PH increase red blood cell to some extent but without actual data, noone can say which is better or worse. Not much that can be done about it since it appears to be a direct effect of androgens. Of course staying hydrated is important to help keep hematocrit from getting to high.
06-20-2010, 01:56 PM
06-20-2010, 05:07 PM
After i came off Epi years ago I feel my body never set back to its normal, maybe this is why. I always maintained a 8-10% bf no matter how many calories i took in, but after my epi cycle my body had no problem getting to 12-14%bf and staying there. Now I maintain that bf and actualy have to fight to get down to 10% !!
06-20-2010, 05:09 PM
I could never figure it out, i was thinking maybe insulin sensitivity (which im curious about but thats another thread) I was sure it changed my metabolism some how.
06-20-2010, 07:08 PM
06-20-2010, 08:52 PM
06-21-2010, 12:54 AM
06-22-2010, 11:15 AM
I am not going to be able to quote studies as I could not find them upon a search -though I will try and find them one more time- but I do recall that the use of hydrocortisone for up to 10 days or so does not suppress endogenous production and patients will have normal levels upon coming off. If we extrapolate these results, would they indicate that 2 week mini cycles may provide fruitful? Are you in general in favor of mini cycles? If so a specific compound or time period?
06-22-2010, 07:38 PM
06-22-2010, 11:23 PM
But with regards to adrenal disruption would you tend to think that adrenals recover very fast (or in some cases almost instantly) from 1-2 week disruptions?
PS: I disagree with you about the 1 pound per week of muscle gain. Especially if you are regaining muscle which you previously held but lost, you can gain several pounds of pure muscle per week IMO. But even brand new muscle can be built at a rate surpassing a pound per week in my opinion. Hard for sure, but I am personally convinced that one can definitively build far more than a pound a week. I have seen several guys gain 15 pounds in 4 weeks cycles (and not extreme cycles either; some garden variety PH/DS). Of course some of it was water + fat. But surely not 11 pounds was; I am absolutely convinced of that as I saw results with my own eyes many many times. However, I do see where you are coming from and why -as a rational person- you would hold the belief that you do.
06-23-2010, 11:52 AM
06-23-2010, 10:09 PM
Anyway, to your first question, it would depend again on the point of disruption. Receptor antagonism is probably more forgiving that enzyme disruption.
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