All about insulin

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    All about insulin


    Originally posted By Dr.Juice at canadian Juice Monsters:

    What is Insulin?
    Insulin is a small polypeptide produced by the pancreatic beta cells. Insulin is crucial for the transport of glucose into the cell. The hormone binds receptor sites on the cell membrane, which promotes movement of glucose- transport proteins from the interior to the surface of the cell. These proteins, in turn, bind glucose and carry it into the cell. As you can see insulin is highly anabolic.

    Insulin is a key player in the control of intermediary metabolism. It has profound effects on both carbohydrate and lipid metabolism, and significant influences on protein and mineral metabolism.

    Like the receptors for other protein hormones, the receptor for insulin is embedded in the plasma membrane. The insulin receptor is composed of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha chains are entirely extracellular and house insulin binding domains, while the linked beta chains penetrate through the plasma membrane.

    The insulin receptor is a tyrosine kinase. In other words, it functions as an enzyme that transfers phosphate groups from ATP to tyrosine residues on intracellular target proteins. Binding of insulin to the alpha subunits causes the beta subunits to phosphorylate themselves (autophosphorylation), thus activating the catalytic activity of the receptor. The activated receptor then phosphorylates a number of intracellular proteins, which in turn alters their activity, thereby generating a biological response.

    Insulin facilitates entry of glucose into muscle, adipose and several other tissues. The only mechanism by which cells can take up glucose is by facilitated diffusion through a family of hexose transporters. In many tissues - muscle being a prime example - the major transporter used for uptake of glucose (called GLUT4) is made available in the plasma membrane through the action of insulin. In the absence of insulin, GLUT4 glucose transporters are present in cytoplasmic vesicles, where they useless for transporting glucose. Binding of insulin to receptors on such cells leads rapidly to fusion of those vesicles with the plasma membrane and insertion of the glucose transporters, thereby giving the cell an ability to efficiently take up glucose. When blood levels of insulin decrease and insulin receptors are no longer occupied, the glucose transporters are recycled back into the cytoplasm.

    It should be noted here that there are some tissues that do not require insulin for efficient uptake of glucose: important examples are brain and the liver. This is because these cells don't use GLUT4 for importing glucose, but rather, another transporter that is not insulin-dependent.

    Insulin stimulates the liver to store glucose in the form of glycogen. A large fraction of glucose absorbed from the small intestine is immediately taken up by hepatocytes, which convert it into the storage polymer glycogen.

    A well-known effect of insulin is to decrease the concentration of glucose in blood, which should make sense considering the mechanisms described above. Another important consideration is that, as blood glucose concentrations fall, insulin secretion ceases. In the absence of insulin, a bulk of the cells in the body become unable to take up glucose, and begin a switch to using alternative fuels like fatty acids for energy. Neurons, however, require a constant supply of glucose, which in the short term, is provided from glycogen reserves.

    In the absence of insulin, glycogen synthesis in the liver ceases and enzymes responsible for breakdown of glycogen become active. Glycogen breakdown is stimulated not only by the absence of insulin, but by the presence of glucagon, which is secreted when blood glucose levels fall below the normal range.

    All of the above was covered in more simplistic terms in Part 3 of the Animalbolics series located elsewhere on this site, so it should be well known to most of you. The writer of those articles has a bit more skill at simplifying terms than I do, so if you are lost, read that article.

    Insulin also effects lipid storage as well. Insulin is stimulatory to synthesis of glycogen in the liver. However, as glycogen accumulates to high levels (roughly 5% of liver mass), further synthesis is strongly suppressed.

    When the liver is saturated with glycogen, any additional glucose taken up by hepatocytes is shunted into pathways leading to synthesis of fatty acids, which are exported from the liver as lipoproteins. The lipoproteins are ripped apart in the circulation, providing free fatty acids for use in other tissues, including adipocytes, which use them to synthesize triglycerides.

    Insulin inhibits breakdown of fat in adipose tissue by inhibiting the intracellular lipase that hydrolyzes triglycerides to release fatty acids.

    Insulin facilitates entry of glucose into adipocytes, and within those cells, glucose can be used to synthesize glycerol. This glycerol, along with the fatty acids delivered from the liver, is used to synthesize triglyceride within the adipocyte. By these mechanisms, insulin is involved in further accumulation of triglyceride in fat cells. This is why high insulin levels leads to the storage of adipose tissue.

    Now for the good news. In addition to insulin's effect on entry of glucose into cells, it also stimulates the uptake of amino acids. This is the reason bodybuilders use insulin.

    Insulin exerts its dramatic anabolic effect by inhibiting muscle breakdown/degradation. This process is believed to occur by the inhibition of the ubqitin-proteasome pathway (one of three major muscle degradation pathways in muscle cells), but once again, little is known about the cellular mechanisms by which insulin exerts this anti-catabolic action. Research does show that the introduction of insulin stops proteolysis (muscle breakdown) and while insulin is driving amino acids and glucose into muscle cells, it appears it also prevents the leakage of these nutrients from the muscle cells that usually occur in response to training. Absence of insulin or allowing insulin levels to drop is the fastest, easiest way to induce muscle protein breakdown (catabolism).

    So why supplement with insulin? Many bodybuilders (especially "natural" bodybuilders) choose to use external sources of insulin. Exogenous insulin is completely undetectable by current drug testing procedures.



    The Basics of Injectable Insulin
    Insulin is described and subdivided by concentration strength, source, and time of onset/peak. This last category is most critical, but an understanding of all three criteria is needed.

    Concentration Strength
    All insulins sold in the United States today are of U-100strength, 100 units of insulin per cc of fluid. (Since most of our readers are American, I'll use American standards throughout this series) But there are other dilutions in other countries, and if you were to encounter one of these (all perfectly usable), and inject your usual volume of insulin, you'd get a different amount of insulin. You'd get the wrong dosage.

    Sources
    At one time, all insulin was produced by laboratory animals, most often cows and pigs. In the last decade, however, American insulin manufacturers have almost completely shifted to use of "recombinant DNA" technology, enabling laboratory production of a close analog to real human insulin. This "human" insulin is said to more closely match our endogenous (pancreatic) insulin. Although labeled much like "animal source" insulins, recombinant DNA insulins are not quite the same, either in time-of-onset or in amount of insulin required. Experience shows that any switch between the one and the other must be done with care, and under your doctor's supervision--the types might be different enough to cause you trouble otherwise.

    Time of Onset/Peak
    The different insulin types: Humalog, Regular, NPH, Lente, Ultralente, and the pre-mixes: 70/30 and 50/50, divided and distinguished by their time of onset and duration. As shown in the chart below, critical questions that you MUST know are:

    1. When does this insulin begin to act in my body?
    2. When does it reach its peak?
    3. When does it fade to insignificance?

    NOTE: Each human body is different. Charts reflect averages -- you may well find a given insulin is different for you. Below is a general approximation, derived from data furnished by both U.S. insulin manufacturers, Eli Lilly and Company and Novo Nordisk Pharmaceuticals Inc.

    Usual Action Times:

    (Table Key)
    1. Onset
    2. Peak Action
    3. Duration

    Humalog
    1. 15 min.
    2. 1/2 -1 1/2 hrs
    3. 3-5 hrs

    Regular
    1. 1/2 hr
    2. 2-4 hrs
    3. 6-8 hrs

    NPH, Lente
    1. 1-3 hrs
    2. 6-12 hrs
    3. 18-26 hrs

    Ultralente
    1. approx. 4-8 hrs
    2. 12-18 hrs
    3. approx. 24-28 hrs

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    Good post Bone... between you and Raybravo I might finally learn more about insulin

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    Good stuff, brother!

    I'm still scared to try it, maybe some Glucophage for my next pre-show carb-up..
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    pete , make sure ure used to glucophage though , cos initially , u get some pretty nasty ****s on it , and lol , u make really loud noises ****ting lol , now i like it , and never am gonna get off it . but although its appetite supressant , dont use it all along for ur pre contest prep , just use it to carb up .
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    Originally posted by Bone
    Originally posted By Dr.Juice at canadian Juice Monsters:


    Sources
    At one time, all insulin was produced by laboratory animals, most often cows and pigs. In the last decade, however, American insulin manufacturers have almost completely shifted to use of "recombinant DNA" technology, enabling laboratory production of a close analog to real human insulin. This "human" insulin is said to more closely match our endogenous (pancreatic) insulin. Although labeled much like "animal source" insulins, recombinant DNA insulins are not quite the same, either in time-of-onset or in amount of insulin required. Experience shows that any switch between the one and the other must be done with care, and under your doctor's supervision--the types might be different enough to cause you trouble otherwise.

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    actually , i used porcine slin , its the same as humalog , same onset time evrything , just need to make sure u got the onset timing right . and u shud know how to eat right on slin . its quite simple .
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    INSULIN USE: IS IT WORTH IT?
    Although I despise the anti-insulin propaganda, which I have contributed to in the past, it does have some merit. Personally I wouldn't care about people dying from insulin use, if only it didn't expose this drug in a negative light. I simply see insulin screwups as somebody sticking **** into their bodies that they know nothing about(meaning: it is on 8 thier 8 head).But in my position I have to wonder why the person tried the stuff in the first place. Lately I've been quite curious about peoples'insulin use because, to be honest, the **** just isn't that great! Don't get me wrong I'd never recommend another AS cycle without it, and you'd have to be a moron to spend $8000. on GH without learning the finer points of insulin use...but there's no reason for people to be using this stuff on a "try it and see" basis. Personally I wouldn't let some guy in an article stop me from trying this normally safe (with responsible use) drug, and I would never try to dis!suade anyone who "has to know" that it is like. But seriously, there's no other reason, for anyone not trying to maximize muscle mass, to use this drug. I don't like it but it's the truth, so I have to report it. For me(the genetic loser of the century), insulin doesn't do much without AS. I will always use it as a training aid, but that's only because I've already gone through the bull**** of planning out my body's reaction to the stuff. I also like the fact that I've come to know my body better than I could have without insulin, but that's only because I've had (too) many sugar crashes to help me feel my serum glucose status. To end this depressing section I have to restate that this is not intended as some "life-saving", anti-insulin propaganda. I'm just stating that insulin doesn't do that much (notable exceptions already mentioned) and certainly doesn't deserve all the hype (good or bad). [I think I'm going to cry now.]
    Description: This description was taken directly from Brian Raupp's Anabolix Research page since this drug is so dangerous and his description is by far the most comprehensive that I have found on the internet.
    Insulin is a hormone produced in the pancreas which helps to regulate glucose levels in the body. Medically, it is typically used in the treatment of diabetes. Recently, insulin has become quite popular among bodybuilders due to the anabolic effect it can offer. With well-timed injections, insulin will help to bring glycogen and other nutrients to the muscles.
    In America, regular human insulin is available without a prescription by the name of Humulin R by Eli Lilly and Company. It costs about $20 for a 10 ml vial with a strength of 100 IU per ml. Eli Lilly and Company also produces 5 other insulin formulations, but none of these should be used by bodybuilders. Humulin R is the safest because it takes effect quickly and has the shortest duration of activity. The other insulin formulations remain active for a longer time period and can put the user in an unexpected state of hypoglycemia.
    Hypoglycemia occurs when blood glucose levels are too low. It is a commonand potentially fatal reaction experienced by insulin users. Before an athlete begins taking insulin, it is critical that he understands the warning signs and symptoms of hypoglycemia. The following is a list of symptoms which may indicate a mild to moderate hypoglycemia: hunger, drowsiness, blurred vision, depressive mood, dizziness, sweating, palpitation, tremor, restlessness, tingling in the hands, feet, lips, or tongue, lightheadedness, inability to concentrate, headache, sleep disturbances, anxiety, slurred speech, irritability, abnormal behavior, unsteady movement, and personality changes. If any of these warning signs should occur, an athlete should immediately consume a food or drink containing sugar such as a candy bar or carbohydrate drink. This will treat a mild to moderate hypoglycemia and prevent a severe state of hypoglycemia. Severe hypoglycemia is a serious condition that may require medical attention. Symptoms include disorientation, seizure, unconsciousness, and death.
    Insulin is used in a wide variety of ways. Most athletes choose to use it immediately after a workout. Dosages used are usually 1 IU per 10-20 pounds of lean bodyweight. First-time users should start at a low dosage and gradually work up. For example, first begin with 2 IU and then increase the dosage by 1 IU every consecutive workout. This will allow the athlete to safely determine a dosage. Insulin dosages can vary significantly among athletes and are dependent upon insulin sensitivity and the use of other drugs. Athletes using growth hormone and thyroid will have higher insulin requirements, and therefore, will be able to handle higher dosages.
    Humilin R should be injected subcutaneously only with a U-100 insulin syringe. Insulin syringes are available without a prescription in many states. If the athlete can not purchase the syringes at a pharmacy, he can mail order them or buy them on the black market. Using a syringe other than a U-100 is dangerous since it will be difficult to measure out the correct dosage. Subcutaneous insulin injections are usually given by pinching a fold of skin in the abdomen area. To speed up the effect of the insulin, many athletes will inject their dose into the thigh or triceps.
    Most athletes will bring their insulin with them to the gym. Insulin should be refrigerated, but it is all right to keep it in a gym bag as long as it is kept away from excessive heat. Immediately after a workout, the athlete will inject his dosage of insulin. Within the next fifteen minutes, he should have a carbohydrate drink such as Ultra Fuel by Twinlab. The athlete should consume at least 10 grams of carbohydrates for every 1 IU of insulin injected. Most athletes will also take creatine monohydrate with their carbohydrate drink since the insulin will help to force the creatine into the muscles. An hour or so after injecting insulin, most athletes will eat a meal or consume a protein shake. The carbohydrate drink and meal/protein shake are necessary. Without them, blood sugar levels will drop dangerously low and the athlete will most likely go into a state of hypoglycemia.
    Many athletes will get sleepy after injecting insulin. This may be a symptom of hypoglycemia, and an athlete should probably consume more carbohydrates. Avoid the temptation to go to bed since the insulin may take its peak effect during sleep and significantly drop glucose levels. Being unaware of the warning signs during his slumber, the athlete is at a high risk of going into a state of severe hypoglycemia without anyone realizing it. Humulin R usually remains active for only 4 hours with a peak at about two hours after injecting. An athlete would be wise to stay up for the 4 hours after injecting.
    Rather than waiting to the end of a workout, many athletes prefer to inject their insulin dosage 30 minutes before their training session is over and then consume a carbohydrate drink immediately following the workout. This will make the insulin more efficient at bringing glycogen to the muscles, but it will also increase the danger of hypoglycemia. Some athletes will even inject a few IUs before lifting to improve their pump. This practice is extremely risky and best left to athletes with experience using insulin. Finally, some athletes like to inject insulin upon waking in the morning. After the injection, they will consume a carbohydrate drink and then have breakfast within the next hour. Some athletes find this application of insulin very beneficial for putting on mass, while others will tend to put on excess fat using insulin in this way.
    Insulin use can not be detected during a drug test. For this reason, along with the fact that it is cheap and readily available, insulin has become a popular drug among the competitive athlete. However, before an athlete attempts to use insulin, he should educate himself and make himself aware of the consequences. One mistake in dosage or diet can be potentially fatal.
    Effective Dose: 1 IU per 10 - 20 lbs. of body weight
    Street Price: Can be bought over-the-counter for around $15 - 20 / 10 cc. bottle Humulin-R
    The Physiological Role of Insulin in the Body: Insulin is a hormone which is manufactured in the pancreas and which has a number of important physiological actions in the body. It is an essential hormone in maintaining the body's blood glucose level so that the brain, muscles, heart and other tissues are adequately supplied with the fuel they require for normal cellular metabolism and normal function. Insulin also plays an essential role in fat and protein metabolism. For example, it promotes transport of amino acids from the bloodstream into muscle and other cells. Within these cells, insulin increases the rate of incorporation of amino acids into protein (amino acids are the building blocks of protein) and reduces protein break down in the body ("catabolism"). These physiological actions probably form the basis of speculation regarding the additional anabolic gains which might be made through the use of exogenously administered insulin.
    Normally, blood glucose and blood insulin levels are not both elevated for any extended period of time as these two chemicals influence each other through a feedback system in the body. In the post-absorptive state, the blood insulin concentration tends to decrease during exercise, allowing the blood glucose to be maintained at or above resting levels and to provide increased energy supplies (fuel) to muscle cells. Following a meal, the blood glucose and amino acid levels rise (the absorptive state) and this triggers an increase in insulin release from the pancreas, driving glucose and amino acids from the blood into cells and maintaining the blood glucose level within a certain physiological (operating) range.
    Intending users should also be aware that insulin stimulates lipid (fat) synthesis from carbohydrate ("lipogenesis"), decreases fatty acid release from tissues ("lipolysis") and leads to a net increase in total body lipid stores. The development of such increased body fat stores runs counter to the training goals of most body builders, athletes and those seeking to improve their physical appearance.
    In striving to become bigger, stronger, more competitive or more physically attractive you should also remember that no matter what you do, your genetic make-up will have an influence on what you are able to achieve. It is important to realize that you cannot look exactly like the role model you admire because you have inherited a different set of genes.
    The Glycemic Index Factor: Scientists have discovered that carbohydrate containing foods can be measured and ranked on the basis of the rate and level of blood glucose increase they cause when eaten. This measurement is called the "Glycemic Index" or "G.I. factor". The rate at which glucose enters the bloodstream affects the insulin response to that food and ultimately affects the rate at which this glucose (fuel) is made available to exercising muscles. (2)
    Low G.I. foods are those measuring less than 50 on a scale of 1-100. Moderate G.I. foods are those with a reading of 50-70 and high G.I. foods are those measuring 71 or greater on this scale. Pure glucose has a G.I. of 100.
    Foods which have a high G.I. produce a rapid increase in blood glucose and blood insulin levels. Examples of such high G.I. foods are potatoes, ice cream, many cereals particularly those with a high sugar content, some varieties of rice (e.g. Calrose) and sweets.
    Foods with an moderate G.I. include some brands of muesli, some varieties of rice, white or brown bread, honey and some cereals.
    Foods with a low G.I. produce a slower, smaller but more sustained increase in blood glucose levels. Examples of such low G.I. foods are pasta, varieties of high amylose rice, barley, instant noodles, oats, heavy grain breads, lentils, and many fruits such as apples and dried apricots. Low G.I foods are advantageous if consumed at least two hours before an event. This gives time for this food to be emptied from the stomach into the small intestine. Since these foods are digested and absorbed slowly from the gastro-intestinal tract, they continue to provide glucose to muscle cells for a longer period of time than moderate or high G.I. foods, particularly towards the end of an event when muscle glycogen stores may be running low. In this way, low G.I. foods can increase a person's exercise endurance and prolong the time before exhaustion sets in.(2)
    High G.I. foods, preferably in the form of liquid foods or glucose drinks of approximately 6% in concentration, can enhance endurance during a very strenuous event lasting more than 90 minutes. ("strenuous" being defined as an athlete exercising at more than 65% of their maximum capacity). Some athletes may prefer food rather than liquid replenishment. Miller(2) suggests glucose enriched honey sandwiches, which have a G.I. factor of 75 or jelly beans, which have a G.I. factor of 80.
    Miller suggests that an athlete who is engaged in a prolonged strenuous event should consume between 30 and 60 grams of carbohydrate per hour during the event.
    High G.I. foods are also desirable after completing an exhausting sporting or training event when muscle and liver glycogen stores have been depleted, as they provide a rapidly absorbed source of glucose and stimulate insulin release from the pancreas. This insulin in turn stimulates the absorption of glucose into liver and muscle cells and its storage as hepatic and muscle glycogen, optimizing recovery and preparation for the next training or competitive event.
    It has been shown that greatest benefit can be had if an athlete consumes these high G.I. carbohydrate foods as soon as possible after an event, preferably within an hour or less. It is further recommended that a high carbohydrate intake be maintained during the next 24 hours. Miller suggests eating at least one gram of carbohydrate per kilogram body weight each 2 hours after prolonged heavy exercise and at least 10 grams of high G.I. carbohydrate per kilogram body weight over the 24 hour period following this exercise.
    For these reasons, an athlete who needs to maintain a high level of activity and performance on consecutive days or more extended periods of time should eat large amounts of high G.I. foods. However, a reasonable quantity of low G.I. carbohydrate food should be consumed before an event in order to improve endurance.
    A Natural Method of Maintaining an Elevated Blood Insulin Level: Noting the hypothesis that an elevated blood insulin level may be of some advantage to bodybuilders, Fahey and his colleagues (1993) undertook an experiment in which they fed athletes a liquid meal of "Metabolol", which consisted of 13.0 g protein, 31.9 g carbohydrate and 2.6 g fat per 100 ml and provided 825 kJ of energy.
    These researchers demonstrated that it is possible with such intermittent feeding during intense weight training to maintain a person's blood glucose at or above resting levels and at the same time, significantly increase insulin levels for the duration of the workout. This suggests a potentially effective and safe non-drug method for achieving a sustained elevation of blood insulin levels.
    The authors of this research commented that "theoretically, this could provide a biochemical environment conducive to accelerating the rate of muscle hypertrophy and inhibiting protein degradation." However, the writer knows of no scientific studies which support this theory.
    It is also relevant to note that muscle repair and growth begins in the hours and days following heavy exercise. It is doubtful that the use of insulin just prior to a workout will have any anabolic effects over and above natural processes, at this time. However, use of insulin prior to a workout will certainly expose you to much greater risk of serious harm. If you believe it is beneficial to have a higher insulin blood level during workouts, use the natural method outlined here.
    Level of Risk Associated with Insulin Use: The use of all drugs carries some risk along with potential or perceived benefits, whether used for legitimate medical reasons or for other purposes. Insulin carries some risk even when used by an insulin dependent diabetic, as demonstrated by the observation that some diabetics run into difficulties with their treatment from time to time and often require assistance to restabilize their medical condition and insulin requirements. If used by a healthy non diabetic person in whom there is no natural deficiency in insulin production or reduced insulin sensitivity and in the absence of medical advice and monitoring, the risks may be substantially increased.
    The major risk associated with insulin is a physical state known as hypoglycemia or "low blood sugar". This occurs when the level of glucose in the blood falls below a certain level required for normal body function. If the blood glucose level is substantially reduced below this normal level and if this is not quickly corrected, there is a risk of disorientation, collapse, coma, permanent brain damage and even death. Exercise and reduced food intake decreases the body's need for insulin and increases the risk of hypoglycemia associated with non-medical use of insulin.
    It is difficult to provide a quantitative estimate of risk for any drug but on a scale of risk in relation to other non-medical and unsanctioned drug use, the use of insulin in this manner would rank towards the higher end of the scale. If zero equals "no risk" of harm to a person's health and ten equals "extreme risk", the use of anabolic steroids in a non-medical context might rate towards the middle of the scale of risk (particularly in the medium to long term) whilst insulin would rate higher. This level of risk associated with insulin use will depend on a number of factors:
    Whether the person is a diabetic or not: non-diabetics and lean healthy people are more sensitive to the blood glucose lowering effects of insulin than diabetics;
    Type of insulin: short acting insulin preparations are considerably safer than long acting preparations because with short acting types, it is much easier to avoid hypoglycemia with adequate food intake. With the non-medical use of longer acting insulin preparations, a person is at real risk of experiencing hypoglycemia late in the day, particularly in between meals, during or after exercise and when asleep. Regardless of this advice, some people are in reality using a mixture of short and long acting insulin preparations and exposing themselves to unnecessary increased risk.
    Food intake: the type and timing of food consumed, its glycemic index (the glucose elevating effect) and the amount consumed, Body weight, Timing of insulin administration in relation to food intake and exercise.
    Individual variation: two different people can respond in a very different way to a given dose of insulin, even if they are of a similar height, weight and other personal characteristics. The fact that a certain dose does not seem to cause a problem for one person does not mean this will be so for another. In addition, the response to insulin will also vary greatly within any one individual over time, according to changes in one or more of the above noted factors.
    5-10 Units of a short acting preparation may have little or no observable impact on someone who eats a meal soon before or after but this dose could cause hypoglycemia and collapse in a person who has not consumed adequate food in close proximity to the time when the insulin begins to take effect (insulin starts to take effect within 5-10 minutes if injected by intra-muscular route and in 30-60 minutes if injected by subcutaneous route). Foods with a high glycemic index will maintain the blood glucose level for a short period of time, perhaps an hour or so whilst those with a low glycemic index will provide for more sustained glucose levels.
    Risk Reduction Advice: Given the risks of using insulin for non medical purposes, the best advice one can give is not use it in this way. Even the body building magazines such as "Muscle Media 2000" advise: "If you're thinking about using insulin, think twice - it's really risky!"(3) However, if you are not persuaded by this advice and are determined to pursue its use in the hope of achieving some additional anabolic or other gains, you should take the following precautions:
    Consider using the natural method of raising your blood insulin level during workouts by consuming glucose containing fluids at intervals during exercise. These fluids may have a protein sparing effect and at the same time, will help maintain keep your blood glucose and blood insulin levels. However, if you decide to use insulin, you should consider the following advice:
    Always use insulin in the presence of someone else who knows about and understands the exact risks of using insulin in this manner, so they are able to act quickly and appropriately should something go wrong;
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    Originally posted by raybravo
    dont use it all along for ur pre contest prep , just use it to carb up .
    That's the plan, brother... That would be the only reason for me to use it..
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    I am often against slin usage b/c I do not think it is a drug that should be "fooled around with". Now it definitely has great benefits but I do not think it is a substance that most bber's should use. If you are pro, trying to go pro, or doing contests then I think it would be worth it. However, for everyone else, I feel it should not be used. I know many disagree with me on this but this is just my feelings, take it as you like.
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    Originally posted by size
    I am often against slin usage b/c I do not think it is a drug that should be "fooled around with". Now it definitely has great benefits but I do not think it is a substance that most bber's should use. If you are pro, trying to go pro, or doing contests then I think it would be worth it. However, for everyone else, I feel it should not be used. I know many disagree with me on this but this is just my feelings, take it as you like.
    i agree with u on slin is dangerous etc , but bro , i know its ur view , but dont u think its so wrong ? cos if u dont want to do contests etc etc , why steroids ?

    its just that u want to self improve , and if someone wants to do that by using slin sensibly, then i dont see anything wrong . whatsay ?
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    ray, i understand your point of view. I just feel it has too many possible negatives for me personally and as long as i preach against it, it will keep me away from it like gh so in the long run it saves me money.
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    Originally posted by size
    ray, i understand your point of view. I just feel it has too many possible negatives for me personally and as long as i preach against it, it will keep me away from it like gh so in the long run it saves me money.
    he he he , cheap ass
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    I use a lot of insulin everyday but then again I'm a diabetic type1. Usually I don't chime in on these discussions but there is one thing most people dont understand and that is insulin can kill you, and that is not talking long term effect, it is talking about immediate dangers. Most people think it is like steroids or some other "supp", because they can buy it legally, and think "the more the better". That thinking is dangerous in most cases but with insulin it can be deadly. The normal range for BG is 80-120, I've had lows where 70 feels like hell but I feel fine at 45. 70 is not too bad but 45 is dangerous and if you cant tell you're that low you could be headed for serious trouble.
    Dont get me wrong I am not hell bent on people not using insulin but too many idiots out there will use it and someone will end up in a coma or dead and then the mainstream media will jump in and people will start giving me dirty looks because I am a bodybuilder and I use insulin, not realizing that I am a diabetic and I have to take it to survive.

    One thing to remember is when a person is having a low blood sugar their mind is not always running properly they may get violent this can be bad when the person is 200+ and strong as hell.

    Again, if using just be damn careful.
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