I'm planning to buy 1-AD, but i'm concerned about hairloss and i've read different opinions about this:...
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What do you think about 1-T (or 1-AD), is it mild or not for hairloss?
1AD/1T has a good a:a ratio and it isn't dht related so it should be mild on hair, but i've read 1-Androsterone binds extremely well to the AR (androgen receptor), and this could agravate hairloss, so... i'm very confused with this compound.
Edit. I've found this:
So, it seems that the main factor in steroid's related hairloss is the androgen receptor binding characteristics of the roid, more than the a:a ratio or even if it is dht related or not.
That could explain why some dht related roids like anavar are extremely mild on hair.
BTW, if someone is interested in this, searching info about AR-binding of steroids i've found this:
Acording to this, stanozol/furazadrol would be safer PHs for hair.
BTW, anyone knows if the RBA of 1-Androsterone is the same than the RBA of 1-Test? Anyone knows the RBA of Superdrol?
Steroids and Hair Loss1-testosterone - A legal steroid, at least for the time being. It's very androgenic and very anabolic. Although it's a 5-alpha-reduced steroid it converts to DHT through an unknown pathway, so using Proscar along with it won't avoid DHT conversion. Its anabolic/androgenic ratio (~(1.5-2):1) is slightly higher than that of test (1:1). Be wary while using this product if you value your hair.
Dihydroboldenone/1-Testosterone Profile - MuscleChemistry.comDihydroboldenone, while not overly androgenic, is a potent anabolic. It has been demonstrated that the drug binds extremely well and selectively to the androgen receptor and stimulates androgen receptor transactivation of dependent reporter genes (2, 3). This equates to a drug that possesses the ability to stimulate significant muscle growth while not producing androgenic side effects.
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Also, androgenic side effects would also be extremely infrequent for most users as there is little in the way, in terms of attributes of the drug, to produce these.
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What do you think about 1-T (or 1-AD), is it mild or not for hairloss?
1AD/1T has a good a:a ratio and it isn't dht related so it should be mild on hair, but i've read 1-Androsterone binds extremely well to the AR (androgen receptor), and this could agravate hairloss, so... i'm very confused with this compound.
Edit. I've found this:
cool thread on hairloss - MESO-RxAny androgenic hormone molecule binding to the receptors in your scalp could advance hair-loss in someone prone to MPB. When using steroids, especially those with strong receptor binding characteristics like 1-test or Trenbalone, the actual steroid itself could be a contributing factor to your hair loss, in addition to any elevated levels of DHT in your system.
So, it seems that the main factor in steroid's related hairloss is the androgen receptor binding characteristics of the roid, more than the a:a ratio or even if it is dht related or not.
That could explain why some dht related roids like anavar are extremely mild on hair.
BTW, if someone is interested in this, searching info about AR-binding of steroids i've found this:
Relative Binding Affinity of Anabolic-Androgenic Steroids: Comparison of the Binding to the Androgen Receptors in Skeletal Muscle and in Prostate, as well as to Sex Hormone-Binding Globulin -- SAARTOK et al. 114 (6): 2100 -- EndocrinologyIt is unclear whether anabolic steroids act on skeletal muscle via the androgen receptor (AR) in this tissue, or whether there is a separate anabolic receptor.
When several anabolic steroids were tested as competitors for the binding of [3H]methyltrienolone (MT; 17β-hydroxy-17a-methyl-4,9,11-estratrien-3-one) to the AR in rat and rabbit skeletal muscle and rat prostate, respectively, MT itself was the most efficient competitor. la-Methyl-5a-DHT (la-methyl-DHT; mesterolone) bound most avidly to sex hormone-binding globulin (SHBG) [relative binding affinity (RBA) about 4 times that of DHT].
Some anabolic-androgenic steroids bound strongly to the AR in skeletal muscle and prostate [RBAs relative to that of MT: MT > 19-nortestosterone (NorT; nandrolone) > methenolone (17β-hydroxy-l-methyl-5a-androst-l-en-3-one) > testosterone (T) > la-methyl-DHT]. In other cases, AR binding was weak (RBA values < 0.05): stanozolol (17a-methyl-5a-androstano[3,2-c]pyrazol-17β-ol), methanedienone (17β-hydroxy-17a-methyl-l,4-androstadien-3-one), and fluoxymesterolone (9a-fluoro-11β-hydroxy-17a-methyl-T). Other compounds had RBAs too low to be determined (e.g. oxymetholone (17β-hydroxy-2-hydroxymethylene-17a-methyl-5a-androstan-3-one) and ethylestrenol (17a-ethyl-4-estren-17β-ol).
The competition pattern was similar in muscle and prostate, except for a higher RBA of DHT in the prostate. The low RBA of DHT in muscle was probably due to the previously reported rapid reduction of its 3-keto function to metabolites, which did not bind to the AR [5a-androstane-3a,17β-diol and its 3β-isomer (3a- and 3β-adiol, respectively)].
Some anabolic-androgenic steroids (only a few synthetic) bound to SHBG (la-methyl-DHT >> DHT > T > 3β-adiol > 3a-adiol = 17a-methyl-T > methenolone > methanedienone > stanozolol).
The ratio of the RBA in rat muscle to that in the prostate (an estimate of the myotrophic potency of the compounds) was close to unity, varying only between about 0.4 and 1.7 in most cases. The present data indicate that 1) the existence of a putative anabolic receptor distinct from the AR must be questioned, 2) many anabolic steroids interact with the AR (generally with lower RBA than NorT or T), 3) some steroids with anabolic-androgenic activity in vivo do not bind to the AR, and must have an indirect mechanism of action (e.g. via biotransformation to active compounds, by influencing the metabolism of other steroids, or by displacing them from SHBG). (Endocrinology 114: 2100, 1984)
Acording to this, stanozol/furazadrol would be safer PHs for hair.
BTW, anyone knows if the RBA of 1-Androsterone is the same than the RBA of 1-Test? Anyone knows the RBA of Superdrol?