Sounds interesting. Male breast cancer patients?
I'm basing my opinion my my personal experience. I use Letro as my on-cycle AI when running aromatizables. Even when I'm running 50mg/day of Dianabol along with Test, if I am not very careful with the Letro dose the side effects hit me hard. Loss of libido, depression, lethargy and sore joints - and I usually only use something like 0.25 E3D. It also seems like the ones that get away with running high dosages are the ones buying their Letro in liquid form from "research chemical" websites (most people on this forum I'd bet). I guess that's what leads me to suspect that maybe the products are underdosed. There is also the possibility that I am just "sensitive" to Letro, but I am definitely not alone in my experience, and others that I've seen report similar experiences are also getting their Letro from reputable UGLs rather than from "research chemical" websites.
Fortunately, given the potency of Letro, even if what most people are using is underdosed it most likely is still getting the job done. Also, if you do experience those side effects, which REALLY suck, they usually seem to subside pretty quick given the relatively short half-life of Letro. That said, having been there, I try VERY hard to never find myself there again.
Arimidex is used clinically for male breast cancer and has clinical data on it, so the present discussion isn't too much of a stretch.
Letro has the longest half-life of all the AIs as far as I know. It's half life is 40+ hours (why e3d dosing works well). It has been used in males to boost testosterone with doses as low as .1mg a week. With that said, the sides usually do diminish quickly, though I have read of at least one person who used 2.5mg ed for a few months trying to treat gyno and had libido problems that lasted for a long time after stopping the letro.
I've experienced terribly sore joints at doses as low as .25mg e3d which is my standard on cycle dose too. Side effects become more pronounced as the dose scales up.
"reputable UGLs"-lol, they are no more reputable than the research chemicals for something like letro. Unless you are using brand name Femara tabs (or another countries version of the official RX formulation-so whatever it is called in India IOW) which cost a fortune, you don't know what the hell you have dose-wise unless you get it lab tested yourself.
It is possible that most people use "liquid letro" on this site that use letro, but you also have to bear in mind the fact that ppl in general tend to mega-dose everything nowadays b/c "more is better" to them not necessarily b/c their product is weaker than an equally nebulous UGL variant or Femara proper. This is all just my opinion though.
If you do some googling, you will probably see a recurring post "all you need to know about gyno" or something. An on cycle maintenance dose is much lower than a gyno treatment dose/pyramid, and that post which has been circulated far and wide is (bro-science and all) among the most commonly used letro approaches to gyno treatment. After successful treatment, you can scale back down to maintenance doses. The poster of said thread didn't specify if he was using Femara(R), UGL letro, or research chem letro, so in a sense, I don't think it really matters assuming that whatever you have is relatively close to what it claims to contain.
