I have done one cycle of the 2on/2off/2on, and just finished one 4-week cycle. My first cycle was with 10mg of M1t and a 4AD trans. The second cycle was 10mg M1T, with a 4AD/4OHT trans.
Personally, I liked the 4-week cycle the best. It may have been the addition of the 4OHT, but I suffered from very few sides. Mostly the lower back pain in week two, and some minor bloating. I gained a total of 14.5 pounds, from 205 to 219.5. After doing the 4-week cycle, I will not do the 2on/2off/2on again.
Also, PCT for a 4-week cycle is cheaper. You will use less Nolva, as for the other cycle you will use it during the two off periods.
Some people like the 2on/2off/2on, but I feel I got the most from the 4-week, with less sides. Again, I attribute the possible reasons for less sides due to the addition of the 4OHT. It's kind of expensive, but to me it's worth it.