5-Androstene-3b-17b-Doil, little help!
- 11-19-2009, 12:17 AM
5-Androstene-3b-17b-Doil, little help!
So surfing the net and I come across this stuff but i have never seen it before! anybody with a chemistry back round, or at least knows what they are talking about wanna help me out with this. Methelyated? Worth taking? On a scale from say 1-10, useful, or waste of time?
- 11-19-2009, 12:30 AM
def not methylated, and from what i know 5a reduction as in this should have a very low aromtization to it low estrogenic side effects that is
correct me where i am wrong guys
- 11-23-2009, 01:01 AM
11-23-2009, 01:14 AM
you mean 5-Androstene-3b,17b-diol right ?
5-Androstenediol (androst-5-ene-3beta,17beta-diol or 5-AED) is one of two androstenediols. Its potential use as a radiation countermeasure was studied by Hollis-Eden Pharmaceuticals under the tradename Neumune for the treatment of acute radiation syndrome.
The clinical trials on rhesus monkeys were successful. According to the Hollis-Eden report, only 12.5% of the 40 Neumune-treated animals died versus 32.5% in the placebo group.
Hollis-Eden had applied for a contract from the US Government under the BioShield Request for Proposals (RFP) for radiation countermeasures. After being encouraged for 2.5 years that Neumune was in the competitive range, on March 9, 2007, the RFP was canceled by HHS. According to HHS, "the product was no longer in the competitive range". No further explanation was given. As a result, Hollis-Eden has now withdrawn from the radiation countermeasure field.
Steroidogenesis, with 5-Androstenediol at bottom left.
5-Androstenediol is a direct metabolite of the most abundant steroid produced by the human adrenal cortex, dehydroepiandrosterone (DHEA). 5-Androstenediol is less androgenic than 4-androstenediol, and stimulates the immune system. When administered to rats in vivo, 5-androstenediol has approximately 1/70 the androgenicity of DHEA, 1/185 the androgenicity of androstenedione, and 1/475 the androgenicity of testosterone. Because it induces production of white blood cells and platelets, 5-androstenediol is being developed as a radiation countermeasure by the Armed Forces Radiobiology Research Institute. Until 2007, it was being developed as a radiation countermeasure by Hollis-Eden Pharmaceuticals as Neumune
11-23-2009, 01:33 AM
1. What is it and where does it come from?
5-andro is an anabolic testosterone precursor much like androstenedione. An enzyme in the liver (17-beta hydroxysteroid dehydrogenase) converts it to testosterone, so it's basically one step away. Its technical name is 5-androstene-3-beta,17-beta-diol
2. What does it do and what scientific studies give evidence to support this?
5-androstenediol has the incredible ability to magnify muscle growth, increase energy, and speed recovery times. It compliments the effects of 19-norandrostenedione and androstenedione. Except for one thing--it works three times better!!! Studies show that it converts to testosterone at a rate of 15.76%, compared to the 5.61% of andro and 19-norandro. A highly effective, highly recommended stack is 5-androstenediol, androstenedione, and tribulus terrestris. Tribulus terrestris works to maintain the production of natural luteinizing hormone. This, in turn, works to add to an excellent testosterone-producing stack.
It seems to work a little better than 4-Androstenediol. The benefit to 5-Androstenediol is it may exert anabolic effects in its unconverted state. This means that it might not have to be converted into testosterone to have an anabolic effect on muscle tissue. This is very significant because a large portion of all pro-hormone substrates go unconverted in the body. With 5-Androstenediol, this unconverted portion may be anabolic in muscle tissue.
3. Who needs it and what are some symptoms of deficiency?
All bodybuilders, muscle men, and weight trainers who would like to improve the efficiency of their bodies can benefit from supplementation of 5-androstenediol. Caution: HUGE gains, BIG bodies, and ULTIMATE power may result! The symptoms generally associated with a deficiency do not apply to 5-androstenediol because it is not an essential nutrient.
4. How much should be taken? Are there any side effects?
Recommended doses of 5-androstenediol are between 100 mg and 200 mg per day. Do not exceed 200 mg. Many muscle builders supplement with 100 mg twice per day. Because 5-androstenediol converts directly to testosterone, it has some of the same anabolic side effects as testosterone. These include, deepening of the voice, hair growth, acne, and male pattern baldness. Since 5-androstenediol must be converted, the effects are generally not as pronounced when compared to direct testosterone (illegal steroids). Because of its androgenic properties, it is not a recommended supplement for women.
11-23-2009, 10:47 PM
11-23-2009, 10:58 PM
11-23-2009, 11:02 PM
Even if it converts at 15% the oral availability, just like 4AD is nearly zilch.
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