DHEA derived cortisol blockers

nattydisaster

nattydisaster

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Why is it that 7-oxo dhea has poor oral bioavailability, but 7-hydroxy does not?
 
nattydisaster

nattydisaster

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Is it because the stomach converts the keto group to a hydroxy, which only has about 10% conversion rate?

While this is true, it doesnt make any difference in cortisol inhibition, as the 7-hydroxy isnt what is inhibiting cortisol, but the 7-oxo after the 11b-HSD converts it back...


Am i talking to myself here?
 

dpfisher

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I doubt most of us care about the "why" mostly just the "how"
 

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