DHEA derived cortisol blockers

  1. DHEA derived cortisol blockers


    Why is it that 7-oxo dhea has poor oral bioavailability, but 7-hydroxy does not?
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  2. Anyone?
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  3. Is it because the stomach converts the keto group to a hydroxy, which only has about 10% conversion rate?

    While this is true, it doesnt make any difference in cortisol inhibition, as the 7-hydroxy isnt what is inhibiting cortisol, but the 7-oxo after the 11b-HSD converts it back...


    Am i talking to myself here?
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  4. dpfisher
    dpfisher's Avatar

    I doubt most of us care about the "why" mostly just the "how"

  5. Quote Originally Posted by dpfisher View Post
    I doubt most of us care about the "why" mostly just the "how"
    Either or would be good to know...
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  6. .
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