testosterone........ no evidence of prostate cancer,heart disease risk found in study

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    testosterone........ no evidence of prostate cancer,heart disease risk found in study


    Biotech Week

    February 18, 2004

    SECTION: EXPANDED REPORTING; Pg. 59

    LENGTH: 898 words

    HEADLINE: BETH ISRAEL DEACONESS: "No compelling evidence"of prostate
    cancer,
    heart disease risk found in study

    BODY:

    A retrospective analysis by researchers at Beth Israel Deaconess
    Medical
    Center found no causal relationship between testosterone replacement
    and
    prostate cancer or heart disease risk.

    The comprehensive review of 72 studies, addresses the current
    controversy
    about testosterone replacement therapy and its potential health risks
    to men.

    "We reviewed decades of research and found no compelling evidence
    that
    testosterone replacement therapy increases the incidence of prostate
    cancer or
    cardiovascular disease," said Abraham Morgentaler, MD, a urologist at
    BIDMC and
    associate clinical professor at Harvard Medical School. "Although it
    would be
    helpful to have data from long-term, large-scale studies, it must also
    be
    recognized that there already exists a substantial body of research on
    the
    effects of testosterone in men."

    The study was published in the New England Journal of Medicine.

    Low levels of testosterone affect an estimated 2-4 million men in
    the United
    States, a condition termed hypogonadism, and the prevalence of this
    condition
    increases with age. The symptoms include diminished libido and sense of
    vitality, erectile dysfunction, reduced muscle mass and bone density,
    depression, and anemia.

    The causes of hypogonadism may be classified as primary, meaning
    inadequate
    function of the testes; secondary, inadequate pituitary stimulation of
    the
    testes; or a combination of primary and secondary causes, which is
    common in
    older men. Testosterone supplementation, in the form of injections,
    patches,
    gels and a buccal tablet, is designed to elevate a hypogonadal man's
    testosterone levels into the normal physiologic range and alleviate
    symptoms.

    "Testosterone is only for men who have symptoms of low testosterone
    combined
    with a confirmatory blood test. Testosterone therapy can be beneficial
    and safe
    for these men as long as they are appropriately monitored by their
    physician,"
    said Morgentaler.

    It has been known since the 1940's that severe reductions of
    testosterone can
    cause shrinkage of metastatic prostate cancer, and therefore there has
    been a
    concern that raising testosterone levels might cause growth of any
    hidden
    prostate cancers. However, the study by Ernani L. Rhoden, MD, and
    Morgentaler
    found no connection between higher testosterone levels and prostate
    cancer, nor
    did they find evidence that testosterone treatment causes prostate
    cancer.

    In fact, they note that prostate cancer becomes more prevalent
    exactly at the
    time of a man's life when testosterone levels decline. To date,
    prospective
    studies have demonstrated no difference in prostate cancer incidence
    among
    hypogonadal men using testosterone therapy compared to men in the
    general
    population.

    Regarding benign prostatic hyperplasia (BPH), multiple studies have
    failed to
    demonstrate consistent exacerbation of voiding symptoms during
    testosterone
    supplementation. "The impact of testosterone therapy on benign prostate
    growth
    appears to be mild," said Rhoden, "and rarely of clinical significance.
    However,
    testosterone therapy should be used cautiously in men with severe
    urinary
    symptoms."

    Monitoring the prostate during testosterone therapy is mandatory,
    given the
    theoretical concern that testosterone treatment may stimulate the
    growth of an
    occult cancer. Before and during treatment men should undergo regular
    evaluation, with a digital examination of the prostate, and a blood
    test called
    prostate-specific antigen (PSA). Patients with an abnormal prostate
    exam or an
    elevated PSA should undergo a prostate biopsy before initiating
    testosterone
    replacement to exclude the possibility that cancer is present. To
    monitor BPH,
    they recommend determining a base-line voiding history at the start of
    treatment
    and assessing urinary symptoms at follow-up.

    The belief that testosterone may be a risk factor in cardiovascular
    disease
    is based on the observation that more men than women have
    cardiovascular events
    and men have higher testosterone levels than women. However, Rhoden and
    Morgentaler write that few, if any, data support a causal relation
    between
    higher testosterone levels and heart disease.

    Indeed, several studies suggest that higher testosterone levels may
    actually
    have a favorable effect on atherosclerosis and heart disease. Studies
    of
    testosterone replacement therapy have not demonstrated an increased
    incidence of
    cardiovascular disease, myocardial infarction, stroke, or angina,
    according to
    the retrospective analysis.

    Rhoden and Morgentaler describe other potential risks or side
    effects from
    testosterone replacement therapy as infrequent (acne or oily skin,
    sleep apnea);
    rarely of clinical significance (fluid retention); or reversible with
    cessation
    of treatment (gynecomastia, testicular atrophy or infertility).
    Testosterone
    treatment should be used cautiously or not at all in men with advanced
    liver
    disease. Skin reactions are commonly encountered in men being treated
    with the
    patch with a low incidence observed with testosterone gel (Rhoden EL,
    Morgentaler A. Risks of testosterone-replacement therapy and
    recommendations for
    monitoring. N Engl J Med, 2004;350(5):482-92).

    This article was prepared by Biotech Week editors from staff and
    other

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    Quote Originally Posted by x_muscle
    Biotech Week

    February 18, 2004

    SECTION: EXPANDED REPORTING; Pg. 59

    LENGTH: 898 words

    HEADLINE: BETH ISRAEL DEACONESS: "No compelling evidence"of prostate
    cancer,
    heart disease risk found in study

    BODY:

    A retrospective analysis by researchers at Beth Israel Deaconess
    Medical
    Center found no causal relationship between testosterone replacement
    and prostate cancer or heart disease risk.

    The comprehensive review of 72 studies, addresses the current
    controversy
    about testosterone replacement therapy and its potential health risks
    to men.

    Test replacement and using test for bbing purposes are two very different things. None the less, it is good info.
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    testosterone replacement therapy = HRT isnt it?..
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    Yes.. also called TRT by some..

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