How to Esterify TNE

  1. Advanced Member
    candle25's Avatar
    Stats
    6'1"  182 lbs.
    Join Date
    Nov 2003
    Age
    39
    Posts
    626
    Rep Power
    449
    Level
    21
    Lv. Percent
    77.19%

    How to Esterify TNE


    This is part of a discussion between myself and Spidey from SM. Granted it's not easy, but the process is very sound.

    Dissolve testosterone (10g, 34.7mmol) in 130mL dry dichloromethane. Add pyridine (8.4mL, 104mmol) and DMAP (424mg, 3.47mmol) and cool the solution to 0 deg C. While stirring at 0 deg C, add acetyl chloride (3.7mL, 52.1mmol) dropwise. Stirr at 0 deg C for 5 minutes and then allow the reaction to warm to room temp. The reaction is monitered by TLC to ascertain when it is complete (an hour or two maybe). The yellow solution is transfered to a separatory funnell with dichloromethane and is washed with 3 x 50mL saturated CuSO4 solution (to remove pyridine and DMAP).

    1M HCl solution may be substituted for the CuSO4 solution but if it is, you must wash the organic layer with sat. NaHCO3 solution to remove acid.

    The dichloromethane layer is dried over MgSO4 and the solvent evaporated to give testosterone acetate. It may be a little yellow but it is still good. If you want nice white stuff, a simple column (chromatography) can be used to purify your crude product.

    Here is the mechanism for the reaction:
    Last edited by candle25; 01-16-2004 at 08:42 PM.

  2. Brewing Anabolic Minds
    Chemo's Avatar
    Join Date
    Oct 2002
    Posts
    2,022
    Rep Power
    0
    Level
    29
    Lv. Percent
    28.06%
    Achievements Posting Pro

    For those that can understand the procedure I probably don't need to point this out but you can substitute any X-chloride for your desired product. For example, enanthyl chloride will yield test enanthate.

    Chemo
  3. New Member
    Charlemagne's Avatar
    Join Date
    Jun 2004
    Age
    37
    Posts
    1
    Rep Power
    128
    Level
    1
    Lv. Percent
    39%

    how easy is it to obtain these materials?
    •   
       

  4. Advanced Member
    candle25's Avatar
    Stats
    6'1"  182 lbs.
    Join Date
    Nov 2003
    Age
    39
    Posts
    626
    Rep Power
    449
    Level
    21
    Lv. Percent
    77.19%

    You'd need an account with a chem supplier.
  5. New Member
    Granger's Avatar
    Join Date
    May 2003
    Posts
    3
    Rep Power
    143
    Level
    2
    Lv. Percent
    16.5%

    I was just about to ask this question....damn i luv the search function

    now if i can get this procedure thru my thick skull.

    Any chance of a laymans guide for the home experimenter?

    And could it be used with Tren base? That would be too good to be true!
  6. New Member
    fiddler's Avatar
    Join Date
    Aug 2003
    Posts
    181
    Rep Power
    228
    Level
    12
    Lv. Percent
    30.98%

    i just finished a year of organic chemistry and i thought the experiments were pretty simple. you would not believe the products that some people got from their experiments.

    Unless you know what you are doing, these steps may sound simple but they are easy to **** up and then you will find out the hard way that you didn't make what you thought you made.

    CAUTION, big ****ing curve ahead.

    fiddler
  7. Advanced Member
    candle25's Avatar
    Stats
    6'1"  182 lbs.
    Join Date
    Nov 2003
    Age
    39
    Posts
    626
    Rep Power
    449
    Level
    21
    Lv. Percent
    77.19%

    I agree Fiddler. I originaly posted this just so it would be out there. I would never try this myself. There is just too much room for error unless you have some great analytical equipment to verify the results.
  8. New Member
    fiddler's Avatar
    Join Date
    Aug 2003
    Posts
    181
    Rep Power
    228
    Level
    12
    Lv. Percent
    30.98%

    thank god, i thought you guys were going to do this at home.

    the average yield i got in lab was around 60% or so and that is considered good. after a multistep, without refining, i wouldn't put anything i made into me including aspirin.

    It is fun to talk about though. for the manufacturers, it's apparently not that hard. made a giant batch, concentrate, test for purity and that's about that.

    fiddler
  9. Advanced Member
    candle25's Avatar
    Stats
    6'1"  182 lbs.
    Join Date
    Nov 2003
    Age
    39
    Posts
    626
    Rep Power
    449
    Level
    21
    Lv. Percent
    77.19%

    Oh, I don't do any of the things I talk about on these boards. It's all just for fun.
  

  
 

Similar Forum Threads

  1. Repost on how to reduce injection pain
    By Matthew D in forum Anabolics
    Replies: 6
    Last Post: 01-15-2005, 11:20 AM
  2. How To Handle A Newbie
    By YellowJacket in forum General Chat
    Replies: 21
    Last Post: 01-10-2003, 11:37 AM
  3. How to use insulin - the most anabolic hormone
    By Trevdog in forum Anabolics
    Replies: 20
    Last Post: 01-05-2003, 07:35 AM
  4. How to Reduce Soreness
    By YellowJacket in forum Exercise Science
    Replies: 4
    Last Post: 01-01-2003, 06:32 PM
  5. how to administer growth hormone
    By raybravo in forum Anabolics
    Replies: 2
    Last Post: 12-20-2002, 12:56 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in