nice find bravo....stuffs starting to look preety decent....not ready to call it a staple supplement for my cycles but looking better....
Yea and this one is even better! not sounding so bad.
S-Adenosylmethionine (SAMe, Denosyl, Zentonil)
(for veterinary information only)
Brand Name: Denosyl, Zentonil, Novifit
Available in 90 mg tablets, 225 mg tablets, and an assortment of sizes and doses for human consumption
Background
SAMe is a natural biochemical produced in the body from the amino acid methionine. It is involved in several biochemical processes.
Transmethylation
We will attempt to avoid complicate biochemical descriptions by keeping to simple terms. Our cells possess an outer skin called a cell membrane. Cell membranes perform an assortment of functions as they are the interface between the cell and the cell’s environment. Cell membranes are made of special fats called phospholipids.
SAMe biochemically donates its methyl group to these phospholipids, thereby enhancing the abilities and functions of the phospholipids. One specific phospholipid is called phosphatidylcholine, and it makes up the cell membranes of liver cells. Phosphatidylcholine is made using a process involving SAMe such that the more SAMe is available, the more phosphatidylcholine is produced, and the more fluid the liver cell membranes become, leading to better bile flow.
Transsulfuration
After SAMe has donated its methyl group as above, it is gradually converted into a compound called glutathione, which is an antioxidant. Antioxidants serve to protect cells from harmful biochemicals that might cause cancer development or cell death. Since liver cells are directly involved in detoxification of the body, they are especially at risk for accumulating harmful biochemicals. Antioxidants help protect cells, especially in the liver; further, it has been shown that most canine and feline liver patients are deficient in glutathione.
Aminoproplyation
SAMe can be converted to a compound called methylthioadenosine via a process called aminopropylation the details of which we will not review. Methylthioadenosine has direct anti-inflammatory and analgesic properties plus it is supportive of cartilage matrix production.
Use of this Medication
In veterinary medicine this product is chiefly used in liver disease; however, in humans it is frequently recommended for joint pain and mood elevation.
Side Effects
Occasionally, an animal experiences vomiting after SAMe administration, though other than this there are no known side effects of SAMe.
Interactions with other Drugs
There are no known drug interactions for SAMe.
Concerns and Cautions
SAMe is best absorbed on an empty stomach.
SAMe comes in a blister pack (single pill packets with a foil wrapper). SAMe is sensitive to air and moisture and broken tablets should be discarded.
SAMe is considered by the FDA to be a nutritional supplement rather than a drug, which means it does not have to undergo the same rigid testing for efficacy as a licensed drug. There is a definite problem with lack of quality control in regard to nutritional supplements for human consumption thus products for human consumption do not undergo standardized production and may not be of the same quality as the Nutramax® product (Denosyl).
It is our policy not to give dosing information over the Internet.
Date Published: 11/18/2002 2:59:00 PM
Date Reviewed/Revised: 01/26/2009
http://www.veterinarypartner.com/Content.plx?P=A&C=31&A=1319&S=0
