It Is Here!!! The Write-Up for AN's Newest Product!!!!

[rms80]

Enjoy!!!

OK, without further ado....

[size=+3]The ONE™[/size] by

Name: 17a-methyl-etioallocholan-17b-ol-3-hydroxyimine

Standard: Methyltestosterone

Androgenic: 140

Anabolic: 380

Estrogenic Activity: none

Progestational Activity: none

Derivation/Analog of: Dihydrotestosterone

Brief History:

• Dihydrotestosterone (DHT) was first synthesized in 1935.
• Primary active ingredient (17a-methyl-etioallocholan-17b-ol-3-hydroxyimine) was first described by Z. Cekan and B. Pelc, Effects of 1-alkyl substitution on the biological action in a series of androstanes. Steroids 8,209 (1966).
• Never commercially produced – A COMPLETELY NOVEL MOLECULE.

Product Characteristics:

• The One is an oral prohormone of Dihydrotestosterone (DHT), a compound that produces effects 3 to 5 times more potent than testosterone on the androgen receptor.
• The One can inhibit the action of estrogens by acting as a competitive antagonist and/or decreasing the mRNA-induced transcription of estrogenic effects post-binding.
• The One can also act like an aromatase inhibitor, disallowing the conversion of androgens to estrogen.
• The One activates GLUT-4 receptors in skeletal muscle, increasing glycogen uptake. The One is 17-alpha alkylated for greater oral bioavailability.
• The One can significantly lower SHBG levels, allowing for more active product to reach skeletal muscle.

Effects Related to Physique Enhancement:

• Rapid lean body mass gains - typical users report 0.75 lb./day gains for first 2-3 weeks
• Overall hardening effect to physique
• Increased vascularity
• Increased strength
• Dramatically enhanced neural function (coordination) as DHT is the predominant androgen in neural function
• Mood-enhancing effect
• Lipolytic effect (increases fat metabolism)

ADMINISTRATION/DOSAGE:
• Effective dose: 67.5 - 90 mg/day (3-4 capsules) ; DO NOT EXCEED 90 MG/DAY
• Can be taken with or without food; preferably in the AM
• Oral Administration Only
• 4-5 week administration period; do not exceed 5 weeks duration

 

[rms80]

Test Data:

TIME-DEPENDANT COMPARISON TO OTHER NON-AROMATIZING ORAL PRODUCTS IN TERMS OF LEAN BODY MASS GAINS DURING THE FIRST TWO WEEKS OF USAGE:

Binding of Oximes by Steroid Hormone Globulin (SHBG) Compared to Other Compounds:

 

[rms80]

ON CYCLE: TIPS TO MAXIMIZE GROWTH
• Take Complete Balance™ Multi-Vitamin/Multi-Mineral
o Ensures that all essential vitamins and minerals are being taken in daily

• Take Omega Essentials™ EFA/DHA at 3-5 grams per day
o Strengthens cell membranes
o Enhances insulin sensitivity
o Synergistic with the GLUT-4 translocating ability of The One
o Enhances healthy HDL/LDL profiles

• Take Bio-Mend™ Anti-Oxidant formula
o High ORAC Value
o Protects cellular membrane
o Protects transcriptional factors (mRNA and DNA)

• Milk Thistle
o Hepatoprotectant – protects liver health

• In general, maintain a healthy diet and lifestyle:
o Drink Plenty of water- at least 64 oz. per day
o Ingest at least 1 gram of protein per lb. of body weight daily
o Sleep at least 7 hours per night
o Eat lots of fruits and vegetables
o Eat lots of complex carbs
o Eat 5-6 smaller protein and carb-rich meals throughout the day
o Increase calories to at least 500 Kcal/day over your normal intake
o BCAAs and Creatine will be helpful
o Avoid alcohol and tobacco

TRAINING
• 8-15 rep sets- 75-85% of 1RM Max for maximal hypertrophy
• Train 3-5 days per week
• Use Heavy Compound Exercises and Variations
• Squats
• Deadlifts
• Pull-Ups w/ multiple grips
• Bench Press

POST CYCLE: TIPS TO MAXIMIZE RECOVERY & MAINTAIN GAINS

6-BROMODIONE, 50 mg/day
• Aromatase Inhibitor
• Increases free testosterone with minimal endocrine suppression

BIO-MEND™ and COMPLETE BALANCE™ as directed on labels
• Prevent calcium leakage from Sarcoplasmic Reticulum
• Helps to maintain cell membrane integrity
• Helps to maintain healthy HDL/LDL levels
• Helps to protect mRNA and DNA
• Helps to keep adequate nutrient profile

OMEGA ESSENTIALS™ as directed on label
• Increases cell membrane strength
• Helps establish/maintain healthy lipid profiles
• Increases insulin sensitivity

DRIVE™ as directed on label
• Increases Cyclic AMP (cAMP) which in turn can have stimulatory effects on spermatogenesis
• Increases free testosterone
• Increases thyroid output
• Increases calcium uptake and decreases calcium leakage from sarcoplasmic reticulum (SR) increased calcium storage in SR helps to mediate a non-hormonal anabolic response

IGF-2® as directed on label
• Increases free testosterone
• Increases GH output

 

[rms80]

Mechanism of Action/Function:

Absorption
• User ingests compound orally
• Digestion occurs in roughly 20-30 minutes (as with most encapsulated products)
• Compound is absorbed by the duodenum and jejunum of the small intestine, and then is displaced into the hepatic portal vein, (a special blood vessel leading from the digestive tract to the liver) where the compound must undergo the “first pass” through the liver and survive hepatic metabolism.
• Methylation allows the compound to survive the first pass through the liver, protecting the molecule from hepatic enzymatic degradation.
• After first pass, the compound is distributed into the inferior vena cava, and then to the heart for systemic distribution.

Distribution
• The heart pumps the active compound into all different areas of the body during the distribution phase. As is the case with most compounds, SHBG (steroid hormone binding globulin) can remove active compounds from systemic distribution before they reach their target organ (in this case, skeletal muscle).
• Binding proteins such as SHBG are rendered fairly inactive in this situation with the active ingredient in The One, because it is one of only a few compounds that does not carry an actual 3-keto group; it carries a 3-oxime group instead.
• Research has dictated that oximes have little or no binding affinity to SHBG in the blood stream, allowing for more free active substrate to reach their target (the androgen receptor (AR) in skeletal muscle). In essence, the 3-oxime “protects” the molecule from being bound (see graph below) leaving more active substrate in the blood to target skeletal muscle.

Metabolism
• Once The One reaches skeletal muscle, it must interact with specific target androgen receptors to exert the desired effect of increased protein synthesis and increased nitrogen retention.
• Under normal circumstances, DHT is quickly deactivated in the blood by 3a-HSD into 5alpha-androstan-3a,17b-diol, a weak androgen, and its access to target skeletal muscle tissue is restricted.
• There is some evidence that the 3-oxime substituted for 3-keto group may slow this deactivation, allowing for greater binding of the molecule to the AR.
• Oximes are a group of compounds with the general formula R¹R²CNOH, where R1 constitutes an organic side chain, and R2 is another organic group. This forms a ketoxime.
• Oximes exist as two geometric stereoisomers: a syn-isomer and an anti-isomer.
• Oximes are formed by the action of hydroxylamine on ketones.

Receptor Binding
• Because the evidence suggests that active DHT may not be metabolized by 3a-HSD into the weaker 5-alpha-androstan-3a,17b-diol within the skeletal muscle because of the oxime, there is a very good chance that fairly large amounts of DHT will actually bind to the AR in skeletal muscle.
• DHT has a 3 to 5 times greater binding potency on the androgen receptor than testosterone, so the resulting effect from The One is a very powerful growth stimulus on skeletal muscle.
• Androgens can act in a genomic (transcriptive, from direct AR binding) or non-genomic (non-AR binding) fashion on target cells.
• Some examples of non-genomic effects: increased IGF-1 expression, displacement of estrogen and progesterone from receptor sites, displacement of aromatase, and increased uptake of calcium in the sarcoplasmic reticulum.

Genomic Effects and MOA:
• The AR has four functional regions: a hinge region containing a nuclear localization signal, a carboxy-terminal ligand-binding domain (AF-2 site), an amino terminal regulatory domain (AF-1 site) and a DNA-binding domain composed of two zinc fingers.
• ARs that are not ligated are located primarily in the cytoplasm, and are bound to heat shock proteins (HSPs). HSPs stabilize the tertiary structure of the AR, permitting androgen binding.
• When The One binds the AR, there is a resulting dissociation of HSPs from the AR, allowing for dimerization (to be held together by molecular force) of the AR and subsequent tyrosine kinase phosphorylation, resulting in translocation (movement) of the AR to the nucleus.
• When the AR translocates inside the nucleus, it binds androgen response elements located in the enhancer and promoter areas of target genes. This results in the consequential assembly of regulatory proteins, and the creation of an active complex for transcription.
• The regulatory proteins form a cross-bridge with the AR, the RNA polymerase, and the pre-initiation complex. Specific coactivators begin transcription by recruiting protein clusters to DNA that change the chromatin scaffolding to a form that is more active for transcription.
• The resulting activated transcription results in synthesis of mRNA, which is signaled by ribosomes to produce specific proteins. Changes in specific cell proteins follow, which in turn mediate growth responses, nitrogen balance, and protein synthesis, among other things.

Excretion
• The Compound is removed from the body via excretion, through the kidneys via glomelular filtration.


WARNING: This product is only intended to be consumed by healthy adult males 21 years of age or older. Not for use by women. Before using this product, consult with your physician if you are using any prescription or over the counter medicine or if you are unaware of your current medical condition. Do not use this product if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, high cholesterol, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking and MAO-B inhibitor or any other medication. Discontinue use and consult your health care professional if you experience any adverse reaction to this product. Possible androgenic side effects including but not limited to acne, increased risk of male pattern baldness, testicular atrophy and gynecomastia (males), may occur. Do not consume alcohol while taking this product. Do not exceed recommended serving. Store in a cool, dry place with lid tightly closed. Do not use if inner safety seal is broken or missing. KEEP OUT OF REACH OF CHILDREN.
Note: This product may contain ingredients which are banned by some athletic or government associations (including military).

 

[rms80]

STUDIES/CLINICAL INFORMATION:

• Kuhnz W, Fritzemeier KH, Hegele-Hartung C, Krattenmacher R. Comparative progestational activity of norgestimate, levonorgestrel-oxime and levonorgestrel in the rat and binding of these compounds to the progesterone receptor. Contraception. 1995 Feb;51(2):131-9.

• Li QG, Li DZ. Analysis of anti-implantational action of norethisterone-3-oxime. Contraception. 1987 Dec;36(6):667-76.

• Li DZ, Fu GM, Zuo MD, Zhou MY, Zhao XL, Wang GP, Wei ZN. Pharmacokinetic studies of norethisterone-3-oxime and norethisterone-3-oxime acetate in rhesus monkey. J Tongji Med Univ. 1991;11(2):81-7.

• Li QG. Aromatization and hydrolysis of norethisterone-3-oxime in rabbit. J Steroid Biochem Mol Biol. 1994 Jun;49(2-3):227-31.

• Hammerstein J. Prodrugs: advantage or disadvantage? Am J Obstet Gynecol. 1990 Dec;163(6 Pt 2):2198-203.

• Shrivastav TG, Basu A, Kariya KP. One step enzyme linked immunosorbent assay for direct estimation of serum testosterone. J Immunoassay Immunochem. 2003;24(2):205-17.

• Tripathi V, Nara S, Chaube SK, Rangari K, Saroha A, Kariya KP, Singh H, Shrivastav TG. J Development of rapid and sensitive one-step direct enzyme linked immunosorbent assay for 17-alpha-OH-progesterone in serum. Immunoassay Immunochem. 2008; 29(2):117-27.

• Nara S, Tripathi V, Chaube SK, Rangari K, Singh H, Kariya KP, Shrivastav TG. A novel enzyme-linked immunosorbent assay for cortisol using a long-chain biotinylated cortisol-3-CMO derivative. J Immunoassay Immunochem. 2008;29(4):390-405.

• Sinnecker G, Köhler S Sex hormone-binding globulin response to the anabolic steroid stanozolol: evidence for its suitability as a biological androgen sensitivity test. J Clin Endocrinol Metab. 1989 Jun;68(6):1195-200.

• Saartok T, Dahlberg E, Gustafsson JA. Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin. Endocrinology. 1984 Jun;114(6):2100-6.

• Tóth M, Zakár T. Relative binding affinities of testosterone, 19-nortestosterone and their 5 alpha-reduced derivatives to the androgen receptor and to other androgen-binding proteins: a suggested role of 5 alpha-reductive steroid metabolism in the dissociation of "myotropic" and "androgenic" activities of 19-nortestosterone. J Steroid Biochem. 1982 Dec;17(6):653-60.

• Lu NZ, Wardell SE, Burnstein KL, Defranco D, Fuller PJ, Giguere V, Hochberg RB, McKay L, Renoir JM, Weigel NL, Wilson EM, McDonnell DP, Cidlowski JA (December 2006). "International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors". Pharmacol. Rev. 58 (4): 782–97.

• Hammond GL, Abrams LS, Creasy GW, Natarajan J, Allen JG, Siiteri PK.
• Serum distribution of the major metabolites of norgestimate in relation to its
• pharmacological properties. Contraception. 2003 Feb;67(2):93-9.

• Juchem M, Pollow K, Elger W, Hoffmann G, Möbus V. Receptor binding of norgestimate--a new orally active synthetic progestational compound. Contraception. 1993 Mar;47(3):283-94.

• Ouyang G, Chen Z, Cai XJ, Song BA, Bhadury PS, Yang S, Jin LH, Xue W, Hu DY, Zeng S. Synthesis and antiviral activity of novel pyrazole derivatives containing oxime esters group. Bioorg Med Chem. 2008 Nov 15;16(22):9699-707. Epub 2008 Oct 2.

• Shrivastav TG, Kanaujia PK. Direct radioimmunoassay for the measurement of serum testosterone using 3H as label. J Immunoassay Immunochem. 2007;28(2):127-36.

• Basu A, Shrivastav TG One step enzyme linked immunosorbent assay for direct estimation of serum cortisol. J Immunoassay. 2000 Feb;21(1):39-50.

• Koji Sato, Motoyuki Iemitsu, Katsuji Aizawa, and Ryuichi Ajisaka Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle. Am J Physiol Endocrinol Metab 294: E961-E968, 2008.

• Davison SL, Bell R (April 2006). "Androgen physiology". Semin. Reprod. Med. 24 (2): 71–7.

• Ly LP, Jimenez M, Zhuang TN, Celermajer DS, Conway AJ, Handelsman DJ. A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency.

• Cailleux-Bounacer A, Rohmer V, Lahlou N, Lefebvre H, Roger M, Kuhn JM.
• Impact level of dihydrotestosterone on the hypothalamic-pituitary-leydig cell axis in men. Int J Androl. 2007 Oct 11.

• Kunelius P, Lukkarinen O, Hannuksela ML, Itkonen O, Tapanainen. The effects of transdermal dihydrotestosterone in the aging male: a prospective, randomized, double blind study. JSJ Clin Endocrinol Metab. 2002 Apr;87(4):1467-72.

• de Lignieres B. Transdermal dihydrotestosterone treatment of 'andropause'. Ann Med. 1993 Jun;25(3):235-41.

• Sakhri S, Gooren LJ. Safety aspects of androgen treatment with 5alpha-dihydrotestosterone. Andrologia. 2007 Dec;39(6):216-22.

• Boada LD, Fernández L, Zumbado M, Luzardo OP, Chirino R, Díaz-Chico BN.
• Identification of a specific binding site for the anabolic steroid stanozolol in male rat liver microsomes. J Pharmacol Exp Ther. 1996 Dec;279(3):1123-9.

• Fernández L, Chirino R, Boada LD, Navarro D, Cabrera N, del Rio I, Díaz-Chico BN. Stanozolol and danazol, unlike natural androgens, interact with the low affinity glucocorticoid-binding sites from male rat liver microsomes. Endocrinology. 1994 Mar;134(3):1401-8.

• Guillon G. Experiment with mesterolone in male fertility disorders Z Hautkr. 1975 Apr 1;50(7):293-7.

• Szöllösi J, Falkay GY, Sas M. Mesterolone treatment of patients with pathospermia. Int Urol Nephrol. 1978;10(3):251-6.

• Nikkanen V. Plasma cholesterol, triglycerides, FSH and testosterone levels of normolipemic male patients with decreased fertility treated with mesterolone. Andrologia. 1979 Jan;11(1):33-6.

• Jackaman FR, Ansell ID, Ghanadian R, McLoughlin PV, Lewis JG, Chisholm GD.
• The hormone response to a synthetic androgen (mesterolone) in oligospermia.
• Clin Endocrinol (Oxf). 1977 May;6(5):339-45.

• Christiansen, K. in Testosterone Action, Deficiency, and Substitution, Nieschlag, E. and Behre, H.M. eds. Springer-Verlag, New York, 107-142, 1998.

 

[papapumpsd]

A) Where the testers whose data you posted above (in charts) remunerated?

B) Will you please comment on hairloss and this product?

Thanks,

-Papa!-

 

[Mr.50]

Assuming more good information comes out on this.......when will it be available?

How will it effect libido?

Mr.50

 

[rms80]

A) Where the testers whose data you posted above (in charts) remunerated?

B) Will you please comment on hairloss and this product?

Thanks,

-Papa!-

A) No- the testers were not compensated for their role in the testing, monetarily, or with free product (aside from The One that was provided for the testing) for their roles.


B) As far as hairloss- can't say for sure- DHT itself tends to be a factor in androgenetic baldness, but the direct mechanisms behind androgenetic baldness have not been fully ascertained. That being said- probably not going to have a huge effect on the hairline, but I don't have any studies confirming or denying this.

 

[rms80]

Assuming more good information comes out on this.......when will it be available?

How will it effect libido?

Mr.50

1. As for libido- some testers had an increase, and some had no change.

2. Availiable in approx. 4 weeks.

 

[papapumpsd]

A) No- the testers were not compensated for their role in the testing, monetarily, or with free product (aside from The One that was provided for the testing) for their roles.


B) As far as hairloss- can't say for sure- DHT itself tends to be a factor in androgenetic baldness, but the direct mechanisms behind androgenetic baldness have not been fully ascertained. That being said- probably not going to have a huge effect on the hairline, but I don't have any studies confirming or denying this.

Thank you for your reply. Have the testers not commented on whether or not shedding was evident? If not, can you ask them to comment?

Curiously,

-Papa!-

 

[rms80]

Thank you for your reply. Have the testers not commented on whether or not shedding was evident?

Curiously,

-Papa!-

Shedding was one of the things that we most closely watched for during the testing- and none of the testers seemed to notice any type of shedding.

 

[Mr.50]

1. As for libido- some testers had an increase, and some had no change.

2. Availiable in approx. 4 weeks.

Well at least no one had decreases in libido!

Mr.50

 

[pmiller383]

Looks pretty solid, nice job AppNut. Any idea on how this would work with someone utilizing a high fat/ low carb diet like a CKD or AD diet?

 

[rms80]

Well at least no one had decreases in libido!

Mr.50

being a DHT deriv.- it can be hit or miss- some guys report libido increases on winny, and then some guys say that winny completes destroys libido. Mesterolone (proviron) has been used historically as a libido enhancer- and at low doses it actually increases spermatogenesis.....go figure

 

[Mr.50]

being a DHT deriv.- it can be hit or miss- some guys report libido increases on winny, and then some guys say that winny completes destroys libido. Mesterolone (proviron) has been used historically as a libido enhancer- and at low doses it actually increases spermatogenesis.....go figure

Well I guess the only way to know is to try it out!

Let us know as soon as it is available, and the approxmate price?

Thanks.

Mr.50

 

[rms80]

Well I guess the only way to know is to try it out!

Let us know as soon as it is available, and the approxmate price?

Thanks.

Mr.50

price is going to be really great- plus it will be a TRUE 1 month supply, even at some of the higher doses

 

[Mr.50]

price is going to be really great- plus it will be a TRUE 1 month supply, even at some of the higher doses

Wow your making me really excited and now I gotta wait a whole month! Darn it all :FUfinger: LOL


Mr.50

 

[thesinner]

Nice work, Dirk.

 

[vernymac12]

hwere can you purchase this stuff?

 

[ABNRanger]

I know this might be a premature question, but is this considered a mild ph like epi or havoc? Or harsh like sdrol and others? Forgive me if this seems like a dumb question; I am not as knowledgeable about this stuff like some of you guys. I get lost in all the scientific jargon.

 

[rms80]

Looks pretty solid, nice job AppNut. Any idea on how this would work with someone utilizing a high fat/ low carb diet like a CKD or AD diet?

I would start low b/c of the effects of The One on GLUT4- may dry you out a little, blood sugar-wise- but may also work really well from an anti-catabolic/protein-sparing standpoint

would be absolutely fantastic on your re-feed/re-comp days

 

[rms80]

hwere can you purchase this stuff?

nutra- in about 4-5 weeks

 

[rms80]

Nice work, Dirk.

thx

 

[rms80]

I know this might be a premature question, but is this considered a mild ph like epi or havoc? Or harsh like sdrol and others? Forgive me if this seems like a dumb question; I am not as knowledgeable about this stuff like some of you guys. I get lost in all the scientific jargon.

No worries- from using just about everything- I would say more like a hybrid of epi and low-dose s-drol- little stronger than epi- much more potent in terms of gains- no water/bloat, good CNS stimulant effect, so better than most other things for strength

 

[angel77]

I know this might be a premature question, but is this considered a mild ph like epi or havoc? Or harsh like sdrol and others? Forgive me if this seems like a dumb question; I am not as knowledgeable about this stuff like some of you guys. I get lost in all the scientific jargon.

I'd like to know the same thing. Cheers, angel77

 

[Iron Lungz]

My pants just got tighter...

Very intertesting.

 

[sethroberts]

With that kind of water retention anyone using this may want to check their blood pressure.

 

[JJC]

The PCT you provided comprised of AN products only. Was that PCT created as the most suitable combo for PCT, and only happened to include just AN products? Or would there be another, possibly better, group of products for PCT for this specific PH?

Maybe you could provide a list of ingredients you feel would be best suited for PCT for this specific PH, instead of listing products. That way there is no possibility for bias. Or could we just use a pretty standard PCT as we would for any other PH?

Product looks legit, by the way.

 

[rms80]

With that kind of water retention anyone using this may want to check their blood pressure.

doesn't aromatize- and the bp of all the testers was normal

 

[rms80]

The PCT you provided comprised of AN products only. Was that PCT created as the most suitable combo for PCT, and only happened to include just AN products? Or would there be another, possibly better, group of products for PCT for this specific PH?

Maybe you could provide a list of ingredients you feel would be best suited for PCT for this specific PH, instead of listing products. That way there is no possibility for bias. Or could we just use a pretty standard PCT as we would for any other PH?

Product looks legit, by the way.

PCT Choices (my favorites, mix and match ):
6-bromo
6-oxo
nolva
forskolin
chlorophytum
mucuna
anti-oxidants
fish oil
res-v
alcar
cordyceps
cissus
icariin

 

[mixedup]

man 2009 looks like gonna be a BIG year between the one and some of the other products that just hit.