HGH and IGF1
- 08-28-2008, 05:54 AM
- 08-28-2008, 12:10 PM
08-28-2008, 03:00 PM
I guess that crap they say in "powerfulls" profile is garbage then about it being better then hgh since it dos not shut you down like the real stuff.
08-28-2008, 03:11 PM
This is wrong. If you don't know the answer to the question please don't answer it.
Effect of chronic treatment with biosynthetic growth hormone (GH) on the GH response to double GH releasing hormone administration in children with short stature.
Scacchi M; Danesi L; Pincelli AI; Dubini A; Cavagnini F
Cattedra di Endocrinologia II, Universit`a di Milano, Istituto Scientifico Ospedale San Luca, Italy.
J Endocrinol Invest, 20(2):72 6 1997 Feb
Growth hormone (GH) exerts a negative feedback on its own secretion through direct and indirect mechanisms. Normal children, unlike adults, display consecutive GH responses after repeated GH releasing hormone (GHRH) administration. In this study, we investigated the effects of long term GH administration on this peculiar secretory pattern. Eight children with severe short stature and impaired GH responses to suprapituitary provocative stimuli associated with normal GH responsiveness to GHRH, underwent, while on chronic treatment with biosynthetic GH and on the 10th day following drug withdrawal, a double bolus GHRH test (two GHRH injections of 1 microg/kg b.w. given as i.v. boluses two hours apart). During GH therapy the GH response to the first GHRH bolus appeared to be reduced, though not significantly so, compared to that observed at diagnosis; after treatment withdrawal, this response returned quite similar to pretreatment. Both during and after treatment, the GH response to the second GHRH bolus was comparable for magnitude to that evoked by the first application. In conclusion, even prolonged treatments with rhGH do not induce persisting alterations of the physiological mechanisms subserving GH regulation.
08-28-2008, 06:04 PM
Regardless of the OP's mistake, he does have a point. I've just been reading the ad for PowerFull too and it does say that any HGH supplementation will shut down your natural supply.
I don't know from "eight children with severe short stature and impaired GH responses", but I'd be more willing to accept this study if it was done on normal adults.
I love USPLabs, but this question needs answering.
08-28-2008, 06:35 PM
Look at all the info posted in the IGF/HGH forum about GHRH's and GHRP's...there is most definitely a negative feedback loop for IGF/Growth.
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