Clomid & Nolvadex The Dark Side

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    Arrow Clomid & Nolvadex The Dark Side


    AM members,

    Here is our latest article -

    Its a review of the pharmaceutical history, short-term side effects, and long-term consequences to Clomid and Nolvadex -

    It may be of interest to some of you.

    -Pp

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    Very interesting.

    "The damaging evidence from many early rat studies showed severely toxic effects, including the development of cancer in the liver, uterus, or testes upon tamoxifen administration. (30-34,41) However, this evidence was largely disregarded by further test tube studies on human cell-lines which appeared to show a lack of toxic effects. (21)"

    30. Tamoxifen induces hepatocellular carcinoma in rat liver: a 1-year study with two antiestrogens.
    Hirsimaki P, Hirsimaki Y, Nieminen L, et al.
    Arch Toxicol. 1993; 67: 49–4


    "Liver tumors were found in four out of five rats at the highest dose level of tamoxifen (45 mg/kg per day) after 52 weeks of dosing, and these appeared to be hepatocellular carcinomas in three rats."

    45mg/kg/52weeks = 4.05g/200lb/52weeks
    21. Understanding the genotoxicity of tamoxifen?
    David H. Phillips
    Carcinogenesis, Jun 2001; 22: 839 - 849.


    "In summary, in vitro studies with human tissues or cells do not show significant DNA adduct formation by tamoxifen in either hepatocytes or endometrium, and binding by {alpha}-hydroxytamoxifen occurs only at high concentration, probably non-enzymically. In vivo, there is no evidence for adduct formation in human liver, but differing results have been obtained with endometrium."
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    Quote Originally Posted by B5150 View Post
    Very interesting.

    "The damaging evidence from many early rat studies showed severely toxic effects, including the development of cancer in the liver, uterus, or testes upon tamoxifen administration. (30-34,41) However, this evidence was largely disregarded by further test tube studies on human cell-lines which appeared to show a lack of toxic effects. (21)"
    Thanks B5.


    -Pp
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