SPP Presents: SLINtensity

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    Quote Originally Posted by dsade View Post
    Production scheduled for end of next week, or early the following week.

    Awesome, Dsade at it again!

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    WE're setting up a Slintensity/Glycomyx MEGA sale right now through Nutra.

    Show them some demand over on the Nutraplanet forum if you want this priced to KILL.
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    Amino Acids. 2005 Feb;28(1):71-6. Epub 2004 Dec 2.
    The addition of fenugreek extract (Trigonella foenum-graecum) to glucose feeding increases muscle glycogen resynthesis after exercise.

    Ruby BC, Gaskill SE, Slivka D, Harger SG.
    Source

    Department of Health and Human Performance, The University of Montana, Missoula, Montana 59812-1825, USA. brent.ruby@mso.umt.edu

    Abstract

    The purpose of this study was to determine the effects of ingesting an oral supplement containing 4-Hydroxyisoleucine (4-OH-Ile, isolated from fenugreek seeds [Trigonella foenum-graecum]) with a glucose beverage on rates of post-exercise muscle glycogen resynthesis in trained male cyclists. Following an overnight fast (12 hr), subjects completed a 90-minute glycogen depletion ride after which a muscle biopsy was obtained from the vastus lateralis. Immediately and 2 hours after the muscle biopsy, subjects ingested either an oral dose of dextrose (Glu) (1.8 g.kg BW(-1)) or 4-OH-Ile supplement (Glu+4-OH-Ile, including 2.0 mg.kg(-1) 4-OH-Ile with the same oral dose of dextrose) with a second muscle biopsy 4 hours after exercise. Post exercise muscle glycogen concentration was similar for both trials. Overall, there was a significant increase in glucose and insulin concentrations from time 0 throughout the majority of the 4-hour recovery period, with no significant differences between the two trials at any time point. Although muscle glycogen concentration significantly increased from immediately post exercise to 4 hr of recovery for both trials, the net rate of muscle glycogen resynthesis was 63% greater during Glu+4-OH-Ile (10.6+/-3.3 vs. 6.5+/-2.6 g.kg wet wt.(-1).hr.(-1) for the Glu+4-OH-Ile and Glu trials, respectively). These data demonstrate that when the fenugreek extract supplement (4-OH-Ile) is added to a high oral dose of dextrose, rates of post-exercise glycogen resynthesis are enhanced above dextrose alone.

    PMID:15719265 [PubMed - indexed for MEDLINE]
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    And you have a very high extract of this, if I am not mistaken??? Yeah Buddy!!
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    Ignore the directions....they are incorrect.

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    A few studies (not reviewing the thread, so I might have already posted these...) When you notice the new 4-OH Isoleucine study, things will become more clear. PPAR-delta activation (in skeletal muscle) plus an increase in isolated GLUT-4 activity (in skeletal muscle) equals incredible synergy.

    J Atheroscler Thromb. 2009;16(6):888-92. Epub 2009 Dec 22.
    Activating effect of momordin, extract of bitter melon (Momordica Charantia L.), on the promoter of human PPARdelta.

    Sasa M, Inoue I, Shinoda Y, Takahashi S, Seo M, Komoda T, Awata T, Katayama S.
    Source

    Department of Diabetes and Endocrinology, Saitama Medical University, Japan.

    Abstract

    AIM:

    Bitter melon (Momordica charantia L.) is a common vegetable grown in Okinawa that has also been used recently in medicine for the treatment of diseases such as diabetes, hypertension, and dyslipidemia. Among Bitter melon extracts compounds, we focused on an extract known as momordin in the present study, to examine its effect on peroxisome-proliferator activated-receptor (PPAR) delta (also called PPARdelta in rodents) expression and promoter activity of the human PPARdelta gene.
    METHODS:

    A human PPARdelta promoter-reporter plasmid was made as a template from a BAC CLONE (RPCI-11C) containing a -3076 bp (BglI site) +74 bp (EcoRI site) sequence. Luciferase assay of PPARdelta promoter activity was performed using HepG2 cells.
    RESULTS:

    10 and 25 nM Momordin significantly increased the expression of PPARdelta mRNA 1.5-fold (relative to the control). Moreover, 10 and 25 nM Momordin significantly increased PPARdelta promoter activity in a dose-dependent manner, reaching more than 1.5-fold relative to the control.
    CONCLUSION:

    Our present data obtained through successful cloning of the PPARdelta promoter demonstrate that PPARdelta production and activation are upregulated through PPARdelta promoter activity following momordin treatment.

    PMID:20032574 [PubMed - indexed for MEDLINE]
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    Eur J Nutr. 2012 May 19. [Epub ahead of print]
    4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway.

    Jaiswal N, Maurya CK, Venkateswarlu K, Sukanya P, Srivastava AK, Narender T, Tamrakar AK.
    Source

    Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow, 226001, India.

    Abstract

    PURPOSE:

    To determine the effect of 4-Hydroxyisoleucine (4-HIL), an unusual amino acid isolated from the seeds of Trigonella foenum-graecum, on glucose uptake and the translocation of glucose transporter 4 (GLUT4) to plasma membrane in skeletal muscle cells and to investigate the underlying mechanisms of action.
    METHODS:

    Rat skeletal muscle cells (L6-GLUT4myc) were treated with 4-HIL, and the effect on glucose uptake was determined by measuring the incorporation of radio-labeled 2-deoxy-[(3)H]-D: -glucose (2-DG) into the cell. Translocation of GLUT4myc to plasma membrane was measured by an antibody-coupled colorimetric assay.
    RESULTS:

    The prolonged exposure (16 h) of L6-GLUT4myc myotubes to 4-HIL caused a substantial increase in the 2-DG uptake and GLUT4 translocation to the cell surface, without changing the total amount of GLUT4 and GLUT1. Cycloheximide treatment reversed the effect of 4-HIL on GLUT4 translocation to the basal level suggesting the requirement of new protein synthesis. The 4-HIL-induced increase in GLUT4 translocation was completely abolished by wortmannin, and 4-HIL significantly increased the basal phosphorylation of AKT (Ser-473), but did not change the mRNA expression of AKT, IRS-1, GLUT4, and GSK3β.
    CONCLUSION:

    Results suggest that 4-HIL stimulates glucose uptake in L6-GLUT4myc myotubes by enhancing translocation of GLUT4 to the cell surface in a PI-3-kinase/AKT-dependent mechanism.

    PMID:22610671 [PubMed - as supplied by publisher]
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    And a question was posed on the Facebook page why I chose to use the 1% corosolic acid banaba extract....this is why.

    J Nutr. 2005 Feb;135(2):165-71.
    Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells.

    Liu X, Kim JK, Li Y, Li J, Liu F, Chen X.
    Source

    Department of Biochemistry, Edison Biotechnology Institute, College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.

    Abstract

    Obesity is a major risk factor for Syndrome X and type II diabetes (T2D). However, most antidiabetic drugs that are hypoglycemic also promote weight gain, thus alleviating one symptom of T2D while aggravating a major risk factor that leads to T2D. Adipogenesis, the differentiation and proliferation of adipocytes, is a major mechanism leading to weight gain and obesity. It is highly desirable to develop pharmaceuticals and treatments for T2D that reduce blood glucose levels without inducing adipogenesis in patients. Previously, we reported that an extract from Lagerstroemia speciosa L. (banaba) possessed activities that both stimulated glucose transport and inhibited adipocyte differentiation in 3T3-L1 cells. Using glucose uptake assays and Western/Northern blot analyses as major tools and 3T3-L1 cells as a model, we showed that the banaba extract (BE) with tannin removed was devoid of the 2 activities, and tannic acid (TA), a major component of tannins, had the same 2 activities as BE. Inhibitors known to abolish insulin-induced glucose transport also blocked TA-induced glucose transport. We further detected that TA induced phosphorylation of the insulin receptor (IR) and Akt, as well as translocation of glucose transporter 4 (GLUT 4), the protein factors involved in the signaling pathway of insulin-mediated glucose transport. We also demonstrated that TA inhibited the expression of key genes for adipogenesis. Differences between samples with or without TA in all of the quantitative assays were significant (P < 0.05). These results suggest that TA may be useful for the prevention and treatment of T2D and its associated obesity. TA may have the potential to become the lead compound in the development of new types of antidiabetic pharmaceuticals that are able to reduce blood glucose levels without increasing adiposity

    and this...

    Evid Based Complement Alternat Med. 2007 Dec;4(4):401-7.
    Antidiabetes and Anti-obesity Activity of Lagerstroemia speciosa.

    Klein G, Kim J, Himmeldirk K, Cao Y, Chen X.
    Source

    College of Osteopathic Medicine, Edison Biotechnology Institute, Department of Chemistry and Biochemistry, The Molecular and Cellular Biology Program, Department of Biological Science and Department of Biomedical Science, Ohio University, USA.

    Abstract

    The leaves of Lagerstroemia speciosa (Lythraceae), a Southeast Asian tree more commonly known as banaba, have been traditionally consumed in various forms by Philippinos for treatment of diabetes and kidney related diseases. In the 1990s, the popularity of this herbal medicine began to attract the attention of scientists worldwide. Since then, researchers have conducted numerous in vitro and in vivo studies that consistently confirmed the antidiabetic activity of banaba. Scientists have identified different components of banaba to be responsible for its activity. Using tumor cells as a cell model, corosolic acid was isolated from the methanol extract of banaba and shown to be an active compound. More recently, a different cell model and the focus on the water soluble fraction of the extract led to the discovery of other compounds. The ellagitannin Lagerstroemin was identified as an effective component of the banaba extract responsible for the activity. In a different approach, using 3T3-L1 adipocytes as a cell model and a glucose uptake assay as the functional screening method, Chen et al. showed that the banaba water extract exhibited an insulin-like glucose transport inducing activity. Coupling HPLC fractionation with a glucose uptake assay, gallotannins were identified in the banaba extract as components responsible for the activity, not corosolic acid. Penta-O-galloyl-glucopyranose (PGG) was identified as the most potent gallotannin. A comparison of published data with results obtained for PGG indicates that PGG has a significantly higher glucose transport stimulatory activity than Lagerstroemin. Chen et al. have also shown that PGG exhibits anti-adipogenic properties in addition to stimulating the glucose uptake in adipocytes. The combination of glucose uptake and anti-adipogenesis activity is not found in the current insulin mimetic drugs and may indicate a great therapeutic potential of PGG


    It's not all about the Corosolic Acid.
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    What would be a good source of carbs to take with Slintensity, you ask? What about Zoidberg?

    Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 Jul;40(4):374-9.
    [Effect of purple sweet potato flavonoids on metabolism of glucose and lipids in diabetic rats].

    [Article in Chinese]
    Jiang HF, Li XR, Tang C.
    Source

    School of Medicine and Life Sciences, Zhejiang University City College, Hangzhou 310015, China.

    Abstract

    OBJECTIVE:

    To investigate the effects of purple sweet potato flavonoids (PSPF) on blood glucose and lipids levels in diabetic rats.
    METHODS:

    Diabetes was induced by intraperitoneal injection of streptozotocin (STZ, 65 mg.kg(-1)) in rats. The changes of fasting blood glucose and lipids levels in serum and body weight, food and fluid intake of diabetic rats treated with PSPF were examined.
    RESULTS:

    Diabetic symptoms were ameliorated after rats were fed with PSPF. The fasting blood glucose (FBG), GSP, TC, TG, LDL-C were decreased and serum HDL-C levels were increased (P<0.01) in high, medium dose PSPF groups; while FBG, serum GSP, TG, LDL-C were also improved in low dose group (P<0.05 or P<0.01).
    CONCLUSION:

    Purple sweet potato flavonoids can decrease the blood glucose and lipids levels in diabetic rats.

    PMID:21845749 [PubMed - indexed for MEDLINE]
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    Now if only I could find a company with a product featuring High-Anthocyanin Purple Sweet Potato powder....

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    Profile is very impressive. What's the eta on the sale?
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    Quote Originally Posted by Ev52 View Post
    Profile is very impressive. What's the eta on the sale?
    If production comes through, 2 week. More than likely 3 weeks.
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    Quote Originally Posted by dsade View Post
    If production comes through, 2 week. More than likely 3 weeks.
    This gives everyone a little time to save, sell drugs, prostitute, whatever one's preferred method of obtaining money is.
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    Quote Originally Posted by Geoforce View Post
    This gives everyone a little time to save, sell drugs, prostitute, whatever one's preferred method of obtaining money is.
    Keepin it real...
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    Quote Originally Posted by dsade View Post
    Ignore the directions....they are incorrect.

    hmmmm too strong for atkins diet.
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    Quote Originally Posted by MAxximal View Post
    hmmmm too strong for atkins diet.
    Not too strong for me though....would love to compare this to SSV2.
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    Quote Originally Posted by Dewey99 View Post
    Not too strong for me though.
    You're not too strong for me
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    Quote Originally Posted by dbone1026 View Post
    You are way too strong for me
    It's OK Dbone. You'll get there.
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    Quote Originally Posted by Dewey99 View Post
    It's OK Dbone. You'll get there.
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    That is one sexy looking label!
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    Quote Originally Posted by MidwestBeast View Post
    That is one sexy looking label!
    It really is.
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    I have no patience waiting for this product...
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    Did I read correctly? Is it 6 per day at 60 per bottle? Just curious
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    Quote Originally Posted by AE14 View Post
    Did I read correctly? Is it 6 per day at 60 per bottle? Just curious
    I think they said the dosing instructions were incorrect but the Nutritional Info was right.
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    Quote Originally Posted by AE14 View Post
    Did I read correctly? Is it 6 per day at 60 per bottle? Just curious
    That's probably why Matt said to ignore the instructions.
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    thank you guys....got a little worried there.
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    Quote Originally Posted by AE14 View Post
    Did I read correctly? Is it 6 per day at 60 per bottle? Just curious
    As others have said, dosing if off. This is going to be an extremely potent product. 6 per day would be way too much
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    Quote Originally Posted by AE14 View Post
    thank you guys....got a little worried there.
    Sounds like someone is chicken...








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    Quote Originally Posted by MidwestBeast View Post
    Sounds like someone is chicken...







    Who's the chicken?
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    Quote Originally Posted by MidwestBeast

    Sounds like someone is chicken...

    If it is as potent as I think, damn skippy I am chicken.
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    Solid profile and a Cool looking label, Look forward to the release of this
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    Quote Originally Posted by AE14 View Post
    If it is as potent as I think, damn skippy I am chicken.
    Funny thing is, Matt had to scale it back quite a bit, too, because it was far stronger to start. He was testing it with oatmeal cream pies lol
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    Quote Originally Posted by dsade View Post
    WE're setting up a Slintensity/Glycomyx MEGA sale right now through Nutra.

    Show them some demand over on the Nutraplanet forum if you want this priced to KILL.

    When will this combo be available?

    Cheers
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    Quote Originally Posted by Jbrooks View Post
    When will this combo be available?

    Cheers
    We are shooting for either the 18th or the 25th.
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    Quote Originally Posted by dsade View Post
    We are shooting for either the 18th or the 25th.
    Good news!
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    Quote Originally Posted by dsade View Post
    We are shooting for either the 18th or the 25th.
    Sounds awesome. Just enjoyed a bit of GlycoMyx and lifted. Love that pump/energy from the combo!
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    Quote Originally Posted by dsade View Post
    We are shooting for either the 18th or the 25th.
    Giddy up! So excited for this to hit retail. Slintensity + GlycoMyx will = SICK pumps/workouts
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    Very late for this, but damn I'm stoked. Matt always kills.......
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    Quote Originally Posted by BoneDaddy View Post
    Very late for this, but damn I'm stoked. Matt always kills.......
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