SPP Presents: SLINtensity

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  1. can't wait!


  2. You know what smells delicious? 80% 4-OH Isoleucine. Brace yourself...Slintensity is coming.
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  3. For those wondering why, 4-OH isoleucine is usually isolated from Fenugreek at a very low percentage. The properties of fenugreek are VERY diverse and not all desirable. This isolation will be the first of its kind and will blow you away.
    Evolutionary Muse - Inspire to Evolve
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  4. Quote Originally Posted by dsade
    For those wondering why, 4-OH isoleucine is usually isolated from Fenugreek at a very low percentage. The properties of fenugreek are VERY diverse and not all desirable. This isolation will be the first of its kind and will blow you away.
    Just wondering. I heard fenugreek mimics estrogen in the body. Is this true? I already sometimes take fenugreek as a gda once in a while.
    PES R&D

  5. Indian J Med Res. 2010 Jun;131:814-9.
    In vitro estrogenic activities of fenugreek Trigonella foenum graecum seeds.

    Sreeja S, Anju VS, Sreeja S.
    Source

    Cancer Endocrinology Laboratory, Integrated Cancer Research Program, Rajiv Gandhi Center for Biotechnology, Thiruvananthapuram, India. [email protected]

    Abstract

    BACKGROUND & OBJECTIVES:

    Trigonella foenum graecum commonly known as fenugreek, has been widely cultivated in Asia, Africa and Mediterranean countries for the edible and medicinal values of its seeds. Earlier reports show that fenugreek seeds provide a mastogenic effect resulting in enhanced breast size. However, very little is known about its estrogenic effect. The present study investigated the effect of chloroform extracts of fenugreek seeds (FCE) in breast cancer cells for its estrogenic effect, and to assess its capacity as an alternative to hormone replacement therapy (HRT).
    METHODS:

    The effect of FCE on cell proliferation of estrogen receptor (ER) positive breast cancer cells, MCF-7 was studied by MTT assay at a concentration range of 20 to 320 microg/ml. The competitive ER binding assay (HAP assay) was done to find out the ER binding capacity of the extract. Transfection and reporter assay (DLR assay), and RT- PCR with an estrogen responsive gene pS2 were done to find out the transcriptional regulatory activity of FCE.
    RESULTS:

    FCE stimulated the proliferation of MCF-7 cells, showed binding to ER (IC(50) = 185.6 +/- 32.8 microg/ ml) and acted as an agonist for ER mediated transcription via ERE. It also induced the expression of estrogen responsive gene pS2 in MCF-7 cells.
    INTERPRETATION & CONCLUSION:

    Our study provided the evidence for estrogenic activities of fenugreek seeds. Further in vitro and in vivo studies could demonstrate its suitability as an alternative to HRT.
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  6. Quote Originally Posted by JonRubio View Post
    Just wondering. I heard fenugreek mimics estrogen in the body. Is this true? I already sometimes take fenugreek as a gda once in a while.
    I was under the impression that even though 4-OH is extracted from fenugreek that there is absolutely zero chance for aromitization or estrogen effects.

  7. Quote Originally Posted by dsade View Post
    For those wondering why, 4-OH isoleucine is usually isolated from Fenugreek at a very low percentage. The properties of fenugreek are VERY diverse and not all desirable. This isolation will be the first of its kind and will blow you away.
    Something novel and avoiding the ho hum copycats is pretty much a staple of yours. Now it's just expected. Can't wait to see what you come up with.
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  8. Quote Originally Posted by dsade View Post
    BTW, this was triggered by a jackpot on my two new ingredients...not only exceeding my specs, but 20% cheaper than I had planned.
    make me happy....... ultra potent mormodica?

  9. Quote Originally Posted by dsade View Post
    You know what smells delicious? 80% 4-OH Isoleucine. Brace yourself...Slintensity is coming.

    WTF????? 80% 4-OH Isoleucine WOW Matt this is simply insane

  10. Never jumped into the GDA game but this could get me to play.
    Always open light. Itís not what you open with, itís what you finish with. Louie Simmons
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  11. *in for this!

  12. Quote Originally Posted by MAxximal View Post
    make me happy....... ultra potent mormodica?
    Excellent memory. For now, best I found is 10% momordin extract, which should be fine for Slintensity.

    For DCP 2.0, however, I am holding out for at least a 30% extract.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  13. Quote Originally Posted by dsade View Post
    Excellent memory. For now, best I found is 10% momordin extract, which should be fine for Slintensity.

    For DCP 2.0, however, I am holding out for at least a 30% extract.
    Sweet! let`s get ready people....... Jesus!!!! 30% extract can`t wait to down few caps then a deep dish pizza

  14. That will be Slintastic!!
    Always open light. Itís not what you open with, itís what you finish with. Louie Simmons

  15. Looking forward to this Matt you always been on the cutting edge in this industry. Keep up the work.

  16. Time to reveal the long term strategy, between Slintensity and GlycoMyx...

    J Microbiol Biotechnol. 2012 Jan;22(1):147-55.
    Synergic effects of bitter melon and β-Glucan composition on STZ-induced rat diabetes and its complications.

    Kim JW, Cho HR, Moon SB, Kim KY, Ku S.
    Source

    Glucan Corp. Research Institute, Marine Biotechnology Center, Busan 617-763, Korea.

    Abstract

    β-Glucan purified from oats (OG) and bitter melon, Momordica charantia Linn (MC), water extracts have shown favorable effects on diabetes and its complications. We investigated to find out the optimal composition showing hypoglycemic and antidiabetic complication effects in variable compositions (OG:MC = 1:1, 1:2, 1:4, 1:6, 1:8, 1:10, 2:1, 4:1, 6:1, 8:1, 10:1). Extracts were administered orally once a day for 28 days following 7 days post streptozotocin (STZ) dosing. Five rats per group (total 15 groups; Intact, STZ, OG, MC, and the variable composition groups) were selected according to the blood glucose and body weight at 6 days after STZ dosing. After 28 days of extracts dosing, the changes on the body weight, liver and kidney weight, blood glucose, blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), low-density lipoprotein (LDL), and total-cholesterol levels were observed. As the result of STZ-induced diabetes, decreases of body weight, increases of the liver and kidney weights, blood glucose, BUN, creatinine, AST, ALT, LDL, and total-cholesterol levels in STZ control were detected compared with intact control. However, these changes of hyperglycemia, diabetic nephropathy, hepatopathy, and hyperlipemia were dramatically decreased in the OG and MC single-dosing group, and all composition groups. In addition, there were more favorable effects in all composition groups compared with the OG and MC single-dosing groups. Among variable compositions, the OG:MC 1:2 mixed group showed the most synergic effects in this study.

    PMID:22297232 [PubMed - indexed for MEDLINE]
    Free full text
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  17. J Med Food. 2011 Dec;14(12):1496-504. Epub 2011 Aug 23.
    Bitter melon extracts in diabetic and normal rats favorably influence blood glucose and blood pressure regulation.

    Clouatre DL, Rao SN, Preuss HG.
    Source

    Glykon Technologies Group, LLC, Santa Monica, California, USA. [email protected]

    Abstract

    Bitter melon (BM) was tested in normal and streptozotocin (STZ)-induced diabetic rats. First, normal and diabetic Wistar rats were given four test extracts (EX-1-EX-4) of a wild-genotype BM or metformin by intubation. Second, normal Sprague-Dawley rats were divided into control and three test groups given for 52 days one of three BM preparations in food: Chinese or Indian commercial preparations or EX-4 from experiment I. In experiment I, extracts of BM administered at 50 mg/kg of body weight in normal rats reduced blood sugar for 4 hours without, unlike metformin, inducing hypoglycemia. In STZ-induced diabetic rats, two extracts administered at 250 mg/kg decreased glucose levels to values comparable to metformin at 150 mg/kg. At 4 hours, EX-1 and EX-4 significantly reduced blood glucose 67% and 63%, respectively, compared with metformin's 54%. In experiment II, all test groups had lowered systolic, but not diastolic, blood pressure. The China and EX-4 arms had significantly lowered serum glucose levels compared with the control. In the glucose tolerance test, only EX-4 had significantly lowered glucose levels. Only EX-4 had significantly lowered angiotensin converting enzyme (ACE) activity. All active arms showed significance in the losartan challenge (the renin-angiotensin system [RAS]), with the greatest effect in the EX-4 group. In the N(ω)-nitro-l-arginine-methyl ester challenge, only EX-4 exhibited a significant impact on the nitric oxide system, suggesting higher activity in this group. In the STZ-induced diabetic rat model, wild-type BM powerfully lowered glucose levels, and, in healthy adult rats, wild-type BM exhibited beneficial effects in the regulation of blood glucose, in RAS and ACE inhibition, and in nitric oxide generation.

    The combination of our special extract and the Norvaline will have a potent effect on NO generation and vascular dilation.
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  18. Last one for today, and this ties in to my intention to use the High Momordin extract for DCP 2.0

    J Nutr Biochem. 2011 Nov;22(11):1064-73. Epub 2011 Jan 28.
    Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice.

    Wang ZQ, Zhang XH, Yu Y, Poulev A, Ribnicky D, Floyd ZE, Cefalu WT.
    Source

    Center for the Study of Botanicals and Metabolic Syndrome, Pennington Biomedical Research Center, LSU System, Baton Rouge, LA 70808, USA. [email protected]

    Abstract

    Bioactive components from bitter melon (BM) have been reported to improve glucose metabolism in vivo, but definitive studies on efficacy and mechanism of action are lacking. We sought to investigate the effects of BM bioactives on body weight, muscle lipid content and insulin signaling in mice fed a high-fat diet and on insulin signaling in L6 myotubes. Male C57BL/6J mice were randomly divided into low-fat diet control (LFD), high-fat diet (HFD) and HFD plus BM (BM) groups. Body weight, body composition, plasma glucose, leptin, insulin and muscle lipid profile were determined over 12 weeks. Insulin signaling was determined in the mouse muscle taken at end of study and in L6 myotubes exposed to the extract. Body weight, plasma glucose, insulin, leptin levels and HOMA-IR values were significantly lower in the BM-fed HFD group when compared to the HFD group. BM supplementation significantly increased IRS-2, IR β, PI 3K and GLUT4 protein abundance in skeletal muscle, as well as phosphorylation of IRS-1, Akt1 and Akt2 when compared with HFD (P<.05 and P<.01). BM also significantly reduced muscle lipid content in the HFD mice. BM extract greatly increased glucose uptake and enhanced insulin signaling in L6 myotubes. This study shows that BM bioactives reduced body weight, improved glucose metabolism and enhanced skeletal muscle insulin signaling. A contributing mechanism to the enhanced insulin signaling may be associated with the reduction in skeletal muscle lipid content. Nutritional supplementation with this extract, if validated for human studies, may offer an adjunctive therapy for diabetes.
    Copyright © 2011 Elsevier Inc. All rights reserved.
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  19. ^^note the effect on Leptin levels.
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  20. ^^^^^^Very interesting!
    Evolutionary Muse - Inspire to Evolve

    Recoverbro

  21. Note that the action indicated is primarily in L6 myotubes and is NOT insulin dependent.

    Eur J Nutr. 2012 May 19. [Epub ahead of print]
    4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway.

    Jaiswal N, Maurya CK, Venkateswarlu K, Sukanya P, Srivastava AK, Narender T, Tamrakar AK.
    Source

    Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow, 226001, India.

    Abstract

    PURPOSE:

    To determine the effect of 4-Hydroxyisoleucine (4-HIL), an unusual amino acid isolated from the seeds of Trigonella foenum-graecum, on glucose uptake and the translocation of glucose transporter 4 (GLUT4) to plasma membrane in skeletal muscle cells and to investigate the underlying mechanisms of action.
    METHODS:

    Rat skeletal muscle cells (L6-GLUT4myc) were treated with 4-HIL, and the effect on glucose uptake was determined by measuring the incorporation of radio-labeled 2-deoxy-[(3)H]-D: -glucose (2-DG) into the cell. Translocation of GLUT4myc to plasma membrane was measured by an antibody-coupled colorimetric assay.
    RESULTS:

    The prolonged exposure (16 h) of L6-GLUT4myc myotubes to 4-HIL caused a substantial increase in the 2-DG uptake and GLUT4 translocation to the cell surface, without changing the total amount of GLUT4 and GLUT1. Cycloheximide treatment reversed the effect of 4-HIL on GLUT4 translocation to the basal level suggesting the requirement of new protein synthesis. The 4-HIL-induced increase in GLUT4 translocation was completely abolished by wortmannin, and 4-HIL significantly increased the basal phosphorylation of AKT (Ser-473), but did not change the mRNA expression of AKT, IRS-1, GLUT4, and GSK3β.
    CONCLUSION:

    Results suggest that 4-HIL stimulates glucose uptake in L6-GLUT4myc myotubes by enhancing translocation of GLUT4 to the cell surface in a PI-3-kinase/AKT-dependent mechanism.

    PMID:22610671 [PubMed - as supplied by publisher]
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  22. in for updates.

  23. This looks extremely interesting .

  24. Products that make other products work even better. Matt is an evil genius.
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    PM me with any questions!

  25. Can you say SYNERGY!!
    Always open light. Itís not what you open with, itís what you finish with. Louie Simmons

  26. Slintensity experiment 1 was a huge success, in a way. I actually have to dial DOWN the dosage of the 4-OH. Big carb meal and went from zero to hypo in 45 minutes.

    Vascularity - blown, and muscle fullness is obscene, even this morning.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  27. Quote Originally Posted by dsade View Post
    Slintensity experiment 1 was a huge success, in a way. I actually have to dial DOWN the dosage of the 4-OH. Big carb meal and went from zero to hypo in 45 minutes.

    Vascularity - blown, and muscle fullness is obscene, even this morning.
    You must spread some Reputation around before giving it to dsade again.

  28. One lucky guinea pig!! Lol
    Always open light. Itís not what you open with, itís what you finish with. Louie Simmons

  29. Nice , Looking forward to this

  30. I'm shooting for a price point under $25.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless
  

  
 

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