PPAR Delta, insulin-resistance, lipotoxicity, and metabolic efficiency

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    PPAR Delta, insulin-resistance, lipotoxicity, and metabolic efficiency


    As we've been finding with out Momordin research tying Insulin systems with PPAR-delta activity (basically prepping the information for a corrollary product to go with DCP), this study just popped up.

    Activation of PPARdelta up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic beta-cells.
    Wan J, Jiang L, Lü Q, Ke L, Li X, Tong N.

    Department of Endocrinology, West China Hospital of Sichuan University, 37 Guoxue Lane, Chengdu, Sichuan 610041, China.

    Recent evidence indicates that decreased oxidative capacity, lipotoxicity, and mitochondrial aberrations contribute to the development of insulin resistance and type 2 diabetes. The goal of this study was to investigate the effects of peroxisome proliferator-activated receptor delta (PPARdelta) activation on lipid oxidation, mitochondrial function, and insulin secretion in pancreatic beta-cells. After HIT-T15 cells (a beta-cell line) were exposed to high concentrations of palmitate and GW501516 (GW; a selective agonist of PPARdelta), we found that administration of GW increased the expression of PPARdelta mRNA. GW-induced activation of PPARdelta up-regulated carnitine palmitoyltransferase 1 (CPT1), long-chain acyl-CoA dehydrogenase (LCAD), pyruvate dehydrogenase kinase 4 (PDK4), and uncoupling protein 2 (UCP2); alleviated mitochondrial swelling; attenuated apoptosis; and reduced basal insulin secretion induced by increased palmitate in HIT cells. These results suggest that activation of PPARdelta plays an important role in protecting pancreatic beta-cells against aberrations caused by lipotoxicity in metabolic syndrome and diabetes. Copyright © 2009. Published by Elsevier Inc
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    Nice information. But, does any side effect that may occur in it?
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    Activation of PPAR-delta seems to have the least number and seriousness of side effects.
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    Very interesting.
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