Banaba and DCP

[dsade]

Dialing it in, dialing it in...

Biol Pharm Bull. 2008 Apr;31(4):651-5.Click here to read Links
Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice.
Yamada K, Hosokawa M, Yamada C, Watanabe R, Fujimoto S, Fujiwara H, Kunitomo M, Miura T, Kaneko T, Tsuda K, Seino Y, Inagaki N.

Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan.

Corosolic acid (CRA), a constituent of Banaba leaves, has been reported to exert anti-hypertension, anti-hyperinsulinemia, anti-hyperglycemia, and anti-hyperlipidemia effects as well as to induce anti-inflammatory and anti-oxidative activities. The aim of this study was to investigate the inhibitory effects of CRA on the development of obesity and hepatic steatosis in KK-Ay mice, a genetically obese mouse model. Six-week-old KK-Ay mice were fed a high fat diet for 9 weeks with or without 0.023% CRA. Nine-week CRA treatment resulted in 10% lower body weight and 15% lower total fat (visceral plus subcutaneous fat) mass than in control mice. CRA treatment reduced fasting plasma levels of glucose, insulin, and triglyceride by 23%, 41%, and 22%, respectively. The improved insulin sensitivity in CRA-treated mice may be due on part to the increased plasma adiponectin and white adipose tissue (WAT) AdipoR1 levels. In addition, CRA treatment increased the expression of peroxisome proliferator-activated receptor (PPAR) alpha in liver and PPAR gamma in WAT. This is the first study to show that CRA treatment can contribute to reduced body weight and amelioration of hepatic steatosis in mice fed a high fat diet, due in part to increased expression of PPAR alpha in liver and PPAR gamma in WAT.

Increased PPAR-a expression is a VERY good thing, by the way, for total fat burning rate.

 

[Steveoph]

Thanks for that study; I love by Corosolic Acid. If Sam would check his emails more thoroughly, we would have had 20% @ NutraPlanet a few months ago :lol:

 

[dsade]

I'l throw in on that...it works topically, too...hint hint

 

[bolt10]

I'l throw in on that...it works topically, too...hint hint

O really now...

nice info i look forward to w/e you have planned

 

[crazyfool405]

Dialing it in, dialing it in...

Biol Pharm Bull. 2008 Apr;31(4):651-5.Click here to read Links
Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice.
Yamada K, Hosokawa M, Yamada C, Watanabe R, Fujimoto S, Fujiwara H, Kunitomo M, Miura T, Kaneko T, Tsuda K, Seino Y, Inagaki N.

Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan.

Corosolic acid (CRA), a constituent of Banaba leaves, has been reported to exert anti-hypertension, anti-hyperinsulinemia, anti-hyperglycemia, and anti-hyperlipidemia effects as well as to induce anti-inflammatory and anti-oxidative activities. The aim of this study was to investigate the inhibitory effects of CRA on the development of obesity and hepatic steatosis in KK-Ay mice, a genetically obese mouse model. Six-week-old KK-Ay mice were fed a high fat diet for 9 weeks with or without 0.023% CRA. Nine-week CRA treatment resulted in 10% lower body weight and 15% lower total fat (visceral plus subcutaneous fat) mass than in control mice. CRA treatment reduced fasting plasma levels of glucose, insulin, and triglyceride by 23%, 41%, and 22%, respectively. The improved insulin sensitivity in CRA-treated mice may be due on part to the increased plasma adiponectin and white adipose tissue (WAT) AdipoR1 levels. In addition, CRA treatment increased the expression of peroxisome proliferator-activated receptor (PPAR) alpha in liver and PPAR gamma in WAT. This is the first study to show that CRA treatment can contribute to reduced body weight and amelioration of hepatic steatosis in mice fed a high fat diet, due in part to increased expression of PPAR alpha in liver and PPAR gamma in WAT.

Increased PPAR-a expression is a VERY good thing, by the way, for total fat burning rate.

heres another study matt

 

[stxnas]

I like where this is going....

 

[dsade]

I like where this going....

I'll be playing with dosages this week...I'm thinking 100mg 2-3 times a day.

 

[stxnas]

I'm assuming TD will alleviate the possibilities of stomach discomfort, right?

 

[jminis]

Thanks for that study; I love by Corosolic Acid. If Sam would check his emails more thoroughly, we would have had 20% @ NutraPlanet a few months ago :lol:

We've been talking about this for months now. Come on Sam :welcome2:

 

[dsade]

Also, it's not just the corosolic acid...there is something more potent in Banaba...but I'm not sharing yet.

 

[Mulletsoldier]

Check the Materials and Methods, and Discussion portions of that study, d. Very interesting stuff re: PPAR-a encoding gene expression.

 

[Steveoph]

Also, it's not just the corosolic acid...there is something more potent in Banaba...but I'm not sharing yet.

Perhaps the foul taste? :lol: Actually I'm thinking more of Yellow Gold, the 20% CA I have isnt as bad as that, or as yellow.

 

[phantom]

Also, it's not just the corosolic acid...there is something more potent in Banaba...but I'm not sharing yet.

Dsade, are u still experimenting with the doses?Got a few bottles of DCP-would def be interested in tryin this combo when nutra gets it in.And anything else on what else is more potent than CA?

 

[dsade]

Dsade, are u still experimenting with the doses?Got a few bottles of DCP-would def be interested in tryin this combo when nutra gets it in.And anything else on what else is more potent than CA?

It's not just the CA that is the potent part.

And...you should see Banaba extract in Eviscerate, the new topical.

 

[dsade]

1: Evid Based Complement Alternat Med. 2007 Dec;4(4):401-7.Click here to read Click here to read Links
Antidiabetes and Anti-obesity Activity of Lagerstroemia speciosa.
Klein G, Kim J, Himmeldirk K, Cao Y, Chen X.

College of Osteopathic Medicine, Edison Biotechnology Institute, Department of Chemistry and Biochemistry, The Molecular and Cellular Biology Program, Department of Biological Science and Department of Biomedical Science, Ohio University, USA.

The leaves of Lagerstroemia speciosa (Lythraceae), a Southeast Asian tree more commonly known as banaba, have been traditionally consumed in various forms by Philippinos for treatment of diabetes and kidney related diseases. In the 1990s, the popularity of this herbal medicine began to attract the attention of scientists worldwide. Since then, researchers have conducted numerous in vitro and in vivo studies that consistently confirmed the antidiabetic activity of banaba. Scientists have identified different components of banaba to be responsible for its activity. Using tumor cells as a cell model, corosolic acid was isolated from the methanol extract of banaba and shown to be an active compound. More recently, a different cell model and the focus on the water soluble fraction of the extract led to the discovery of other compounds. The ellagitannin Lagerstroemin was identified as an effective component of the banaba extract responsible for the activity. In a different approach, using 3T3-L1 adipocytes as a cell model and a glucose uptake assay as the functional screening method, Chen et al. showed that the banaba water extract exhibited an insulin-like glucose transport inducing activity. Coupling HPLC fractionation with a glucose uptake assay, gallotannins were identified in the banaba extract as components responsible for the activity, not corosolic acid. Penta-O-galloyl-glucopyranose (PGG) was identified as the most potent gallotannin. A comparison of published data with results obtained for PGG indicates that PGG has a significantly higher glucose transport stimulatory activity than Lagerstroemin. Chen et al. have also shown that PGG exhibits anti-adipogenic properties in addition to stimulating the glucose uptake in adipocytes. The combination of glucose uptake and anti-adipogenesis activity is not found in the current insulin mimetic drugs and may indicate a great therapeutic potential of PGG.

 

[phantom]

The new topical sounds bad ass!Also, the PGG from the Banaba sounds very interesting-I'm guessing those extracts are kinda hard to come by at the moment though-unless it's maybe something your'e workn on?

 

[dsade]

The new topical sounds bad ass!Also, the PGG from the Banaba sounds very interesting-I'm guessing those extracts are kinda hard to come by at the moment though-unless it's maybe something your'e workn on?

I learned a while ago to keep my mouth semi-shut about what I'm investing my time and money in.

 

[phantom]

Understandable-lookin forward to what u got comin

 

[rob561]

now this is my kind of thread! topical CA hmmmm sounds interesting

 

[strategicmove]

Nice thread.

 

[crazyfool405]

1: Evid Based Complement Alternat Med. 2007 Dec;4(4):401-7.Click here to read Click here to read Links
Antidiabetes and Anti-obesity Activity of Lagerstroemia speciosa.
Klein G, Kim J, Himmeldirk K, Cao Y, Chen X.

College of Osteopathic Medicine, Edison Biotechnology Institute, Department of Chemistry and Biochemistry, The Molecular and Cellular Biology Program, Department of Biological Science and Department of Biomedical Science, Ohio University, USA.

The leaves of Lagerstroemia speciosa (Lythraceae), a Southeast Asian tree more commonly known as banaba, have been traditionally consumed in various forms by Philippinos for treatment of diabetes and kidney related diseases. In the 1990s, the popularity of this herbal medicine began to attract the attention of scientists worldwide. Since then, researchers have conducted numerous in vitro and in vivo studies that consistently confirmed the antidiabetic activity of banaba. Scientists have identified different components of banaba to be responsible for its activity. Using tumor cells as a cell model, corosolic acid was isolated from the methanol extract of banaba and shown to be an active compound. More recently, a different cell model and the focus on the water soluble fraction of the extract led to the discovery of other compounds. The ellagitannin Lagerstroemin was identified as an effective component of the banaba extract responsible for the activity. In a different approach, using 3T3-L1 adipocytes as a cell model and a glucose uptake assay as the functional screening method, Chen et al. showed that the banaba water extract exhibited an insulin-like glucose transport inducing activity. Coupling HPLC fractionation with a glucose uptake assay, gallotannins were identified in the banaba extract as components responsible for the activity, not corosolic acid. Penta-O-galloyl-glucopyranose (PGG) was identified as the most potent gallotannin. A comparison of published data with results obtained for PGG indicates that PGG has a significantly higher glucose transport stimulatory activity than Lagerstroemin. Chen et al. have also shown that PGG exhibits anti-adipogenic properties in addition to stimulating the glucose uptake in adipocytes. The combination of glucose uptake and anti-adipogenesis activity is not found in the current insulin mimetic drugs and may indicate a great therapeutic potential of PGG.

this sounds yummy

i would like to add this to m cut!!!

 

[dsade]

this sounds yummy

i would like to add this to m cut!!!

the Anti-Adipogenic properties, and effects on PPARs are the reason this is included in the topical.

The stock to Nutra should be there on Friday.


Final active ingredients for Eviscerate are:

Glycyrrhetinic Acid
Yohimbine HCl
Raspberry Ketones
Caffeine Anhydrous
Bergenin
Banaba Leaf Extract
Ginger Extract
Capsaicin 98%
Ellagic Acid 40%
Beta-escin 20%
Aminophylline
Theophylline
Benzyl Nicotinate
Propionyl-L-Carnitine

Bear with me while I perfect the Capsaicin content, I am starting low to assess burn and comfort, and will adjust UP from here.

Now's your chance to provide ideal feedback and be rewarded with close to a 50% discount on the product.

 

[Trauma1]

the Anti-Adipogenic properties, and effects on PPARs are the reason this is included in the topical.

BTW, the topical should be up at one store tonight (see my forum at Mindandmuscle.net) since we do some shipping for them. 4 ounces for $20.

The stock to Nutra should be there on Friday, though their cost (since the licensing of the napalm and lipoderm bases give M&M a discount, plus no shipping) should only be slightly higher.


Final active ingredients for Eviscerate are:

Glycyrrhetinic Acid
Yohimbine HCl
Raspberry Ketones
Caffeine Anhydrous
Bergenin
Banaba Leaf Extract
Ginger Extract
Capsaicin 98%
Ellagic Acid 40%
Beta-escin 20%
Aminophylline
Theophylline
Benzyl Nicotinate
Propionyl-L-Carnitine

Bear with me while I perfect the Capsaicin content, I am starting low to assess burn and comfort, and will adjust UP from here.

Now's your chance to provide ideal feedback and be rewarded with close to a 50% discount on the product.

That looks fantastic, matt. One hell of an ingredient profile for sure. I like the name, haha.

 

[strategicmove]

the Anti-Adipogenic properties, and effects on PPARs are the reason this is included in the topical.

The stock to Nutra should be there on Friday.


Final active ingredients for Eviscerate are:

Glycyrrhetinic Acid
Yohimbine HCl
Raspberry Ketones
Caffeine Anhydrous
Bergenin
Banaba Leaf Extract
Ginger Extract
Capsaicin 98%
Ellagic Acid 40%
Beta-escin 20%
Aminophylline
Theophylline
Benzyl Nicotinate
Propionyl-L-Carnitine

Bear with me while I perfect the Capsaicin content, I am starting low to assess burn and comfort, and will adjust UP from here.

Now's your chance to provide ideal feedback and be rewarded with close to a 50% discount on the product.

Nice formula. I thought you might want to increase the amount of Raspberry Ketones and reduce (or even drop) Capsaicin, as both have an identical chemical structure, and raspberry ketones have most of the beneficial properties of capsaicin without the negatives. Theobromine is the only missing methylxanthine! I will certainly want to give this a shot. Sehr gut! :thumbsup:

 

[Steveoph]

the Anti-Adipogenic properties, and effects on PPARs are the reason this is included in the topical.

The stock to Nutra should be there on Friday.


Final active ingredients for Eviscerate are:

Glycyrrhetinic Acid
Yohimbine HCl
Raspberry Ketones
Caffeine Anhydrous
Bergenin
Banaba Leaf Extract
Ginger Extract
Capsaicin 98%
Ellagic Acid 40%
Beta-escin 20%
Aminophylline
Theophylline
Benzyl Nicotinate
Propionyl-L-Carnitine

Bear with me while I perfect the Capsaicin content, I am starting low to assess burn and comfort, and will adjust UP from here.

Now's your chance to provide ideal feedback and be rewarded with close to a 50% discount on the product.

Looks good dsade, lots of compounds of interest and it should be worth the wait :thumbsup:

 

[dsade]

Nice formula. I thought you might want to increase the amount of Raspberry Ketones and reduce (or even drop) Capsaicin, as both have an identical chemical structure, and raspberry ketones have most of the beneficial properties of capsaicin without the negatives. Theobromine is the only missing methylxanthine! I will certainly want to give this a shot. Sehr gut! :thumbsup:

Capsaicin does other things...and the effectiveness based on trial with and without the ketones cannot be matched. I hesitated as long as possible, as this stuff is an immense headache to both import and work with...but the effects are just too good.

The concentration is pretty low, but enough to feel for HOURS AND HOURS.

 

[bolt10]

looks good

 

[WhatsaRoid?]

I get paid friday, so I'll be sure to pick some up!

 

[strategicmove]

Capsaicin does other things...and the effectiveness based on trial with and without the ketones cannot be matched. I hesitated as long as possible, as this stuff is an immense headache to both import and work with...but the effects are just too good.

The concentration is pretty low, but enough to feel for HOURS AND HOURS.

Got it!

 

[mattikus]

Wow. RPN is really rocking lately! I love you guys! yeah yeah no homo

 

[dsade]

Wow. RPN is really rocking lately! I love you guys! yeah yeah no homo

Why no homo? Is it because I forgot to use my Renegade this morning? Do I look fat?

 

[mattikus]

I just said that for the others.. not necessarily towards you.. and uh, yeah uhh, you look skinny. Very skinny. You look great.

 

[Mulletsoldier]

I just said that for the others.. not necessarily towards you.. and uh, yeah uhh, you look skinny. Very skinny. You look great.

You are saying dsade looks skinny? He does not look muscular to you? What an insult!

 

[dsade]

You are saying dsade looks skinny? He does not look muscular to you? What an insult!

It's all done with mirrors.

 

[Mulletsoldier]

It's all done with mirrors.

....that's what she said?

 

[dsade]

....that's what she said?

yep...but not to me.

 

[Mulletsoldier]

yep...but not to me.

Hm, the reflection probably wasn't clear enough.

 

[dsade]

Hm, the reflection probably wasn't clear enough.

Objects are larger than they appear in mirror?

 

[Mulletsoldier]

Objects are larger than they appear in mirror?

I believe she said that as well.

 

[dsade]

I believe she said that as well.

that BITCH!

wait..who is "she" again?

 

[mattikus]

You are saying dsade looks skinny? He does not look muscular to you? What an insult!

Sigh. I just can't win.