Joint pain mid-cycle usually implies that estrogen levels are suppressed to the point of drying out some areas a bit too much. Dermacrine (in my experience and also in other reviews) does not cause joint pain due to it keeping estrogen in a considerable range for athletism, but it is not to my knowledge a joint saver. It reduces estrogen like most PH/DS, just not as much as your Epistane for example. That would at least be my assumption - they are both PH/DS.
For joint pain, I'd say it would be your best bet to look into joint care formulas, such as Osteobolin-C. A cissus product, but with the extract geared towards joint repair and health(the higher the % of the extract, the more it works for anabolism, and not for joint care). 10% is usually affordable, and has many great reviews.