Primordial Performance Presents: Liver Juice-LV

Trauma1

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This is our new Milk Thistle LV-based product. We have a very nice write-up to go along with this that will be posted up shortly. There is supportive evidence/studies showing Silymarin having the ability to reduce and even prevent instances of pharmacological-induced liver cholestasis (a potential dangerous effect of reduced ductal bile flow within the liver induced by methylated compounds). The night crew gets first crack at this one.

This is a GREAT addition of prevention for those looking for protection while on-cycle.

Get it now!

Click here for Liver Juice-LV!


Steroids for your Liver

We think Liver Juice is so awesome; it could be called Liver Steroids.

But of course, we didn’t want to give the product a bad name.

It appears that milk thistle does to the liver, what anabolic steroids to do the muscles. Milk thistle turns a weak liver to a strong liver (except milk thistle has zero side effects). (1-4)

Ironically, after a formal review of the most current scientific literature on milk thistle, it appears milk thistle has specific protective effects against anabolic/androgenic steroid induced liver toxicity. We will present new and exciting research later in this article.

What’s most disappointing (and damaging to milk thistles reputation) is that 90% of the milk thistle products on the market have super poor absorption at only about 8%. (5-14) Therefore, we had to go the extra mile and create a liquid formula that would actually get milk thistle where it needs to be -- in the liver.

Before I show you exactly how milk thistle works I want to tell you about our impressive accomplishment with our Liver Juice formula, and the break though delivery system. Read on



Meeting the challenge – Mr. Milk Thistle


Try to image mixing a handful of chalk into a glass of water, you would see it either sink to the bottom or precipitate to the top -- that’s pretty close to how well milk thistle mixes into a glass of water.

To show the exceptional solubility accomplished with the milk thistle in our Liver Juice, we went ahead and took a 5mL dose (500mg) of Liver Juice and mixed it into a glass of water. We then took 500mg of the exact same milk thistle extract used in our Liver Juice, and vigorously shook it into a glass of water. Then they sat for 12 hours



As you can see, the milk thistle in Liver Juice remained completely stable and molecularly dispersed in the liquid. The milk thistle powder alone simply crashed to the bottom of glass. (“crash” means to crystallize, separate or no longer be in solution -- aka, not be absorbed into the body)

BTW, what you just witnessed was the result of about 119 hours in the lab, and about 12 months of research.

Anyway, we managed to make a nice milk thistle formula... but listen to why this is so important...



Membrane Invagination

Obviously, milk thistle does not dissolve in water, and hardly dissolves in most oils. (7) This inability to dissolve means milk thistle is very difficult to be absorbed by the human body, since the larger particles cannot pass though the walls of the digestive tract. (5-8, 12) In fact, milk thistle extract alone only absorbs at a rate of about 8% in humans. (5-14)

Unless nutrients are dispersed to micro-particle size, they simply won't be absorbed by the intestines. In order to get the maximum amount of milk thistle absorbed into the body we had to accomplish 3 things when formulating Liver Juice -

1. Modify the Liqua-Vade delivery system so milk thistle can complexly dissolve.

2. Make sure it remains dissolved once mixed in an aqueous environment (such as the stomach).

3. Make it safe and acceptable for drinking.

We ended up accomplishing all 3 goals. But it certainly wasn’t easy.



Editors note: Some of you home chemistry buffs are probably thinking milk thistle could just dissolve into some basic solvent like alcohol or glycerin. That may accomplish the 1st goal, but as soon as those water soluble solvents become diluted in a glass of water they would lose their solvent capacity and that milk thistle would fall out of solution and crash right to the bottom of the glass, therefore putting milk thistle right back to where it started.


Liqua-Vade – Tailored for Mr. Milk Thistle


Because the milk thistle flavones are such stubborn little molecules, we had to custom tailor our Liqua-Vade delivery system just for Liver Juice. We used a precise ratio of 12 different pharmaceutical grade carriers, phospholipids and fatty esters to dissolve our high potency milk thistle into a fine homogenous solution (while managing to give it a nice sweet almond taste).

Rest assured, our Liqua-Vade delivery technology isn’t some hyped up sugar water. It’s based on Self-Emulsifying Drug Delivery System (SEDDS) science, which is backed by dozens of 3rd party human clinical trials and is currently one of the hottest research fields in modern day drug delivery (5-7)

Over the years there have been other attempts at enhancing delivery of milk thistle, however Liqua-Vade delivery technology (SEDDS) trumps them all. (5-14) Just take a look





Bile acids - Liver Cleaners

Bile acids are the liver’s detergents -- flowing through the cellular channels all throughout the liver.

There are dozens of different bile acids created by the liver, all of which are metabolites of cholesterol. Essentially, they are created to dissolve and mobilize toxic material and export it from the liver and into the intestines for excretion. Different bile acids are needed to dissolve and carry different toxins from the liver.

In general, bile acids are your friends. However, certain drugs (including methylated steroids) cause the liver to slow bile acid production, and create a bile acid insufficiency, as well as cause a build up in the hepatotoxic bile acids (15-23) This makes a mess, and causes the liver to get jammed up fast. If the liver gets clogged up enough where bile can no longer flow from the biliary channels, a condition develops known as reversible cholestasis. (the primary condition developed from methylated steroids and birth control use) (15-23)

Luckily this liver condition is reversible. If you have suffered some toxic effects from steroids (or other drugs) you still have a chance to turn it around for the better.


Bile Acid – The Doctors Choice

Bile acid is the drug of choice prescribed to anabolic steroids users admitted for drug induced cholestasis. The drug is known as Ursodiol -- a.k.a. ursodeoxycholic acid. This naturally occurring bile acid is known for its hydrophilic action and ability to detoxify the liver by cleaning out less hydrophilic bile acids, among other toxins such as methylated hormone metabolites. (19, 24-27)

Unfortunately, Ursodiol is an expensive prescription drug, and not easily obtainable.

As I mentioned earlier, there is new and exciting research on milk thistle that we are excited to present. Research has shown us milk thistle has the ability to increase production of this protective bile acid -- ursodeoxycholic acid (at the same relative dose delivered by Liver Juice) (18-23)


The West Side Liver Gang – Cleaning up the Trash

The main active ingredients in milk thistle are flavonolignans, known as silichristin, silidianin, isosilibinin, and the most biologically active player, silybin (Our milk thistle extract is standardized to 30% silybin). (1-4)

When these milk thistle flavonolignans enter the liver they don’t mess around. They immediately start circulating the liver to signal sluggish and under-producing liver cells to pick up the production of liver cleansing bile acids, esspecialy the hepatoprotective variety such as ursodeoxycholic acid. It appears that silybin stimulates Cyp7a1 and Cyp3a enzymes to encorage conversion of cholesterol towards protective and hydrophilic bile acids. (18-23)

Now here is the clincher...

Studies have shown that milk thistle can reverse the down-regulating effect on bile acid production even during the administration of methylated steroids. So when steroids are in the liver inhibiting production of the beneficial bile acids, milk thistle steps in and ramps up beneficial bile acid production while enhancing the export of built up toxins (and methylated steroids) from the liver. (18-23, 28)



Liver Juice - Quick to Battle

With our Liqua-Vade delivery system, the active milk thistle flavones will reach the liver fast. Once absorbed through the intestines the biologically active flavones are immediately carried into the liver, where they begin stimulating the liver cells to revive detoxifying bile acid production. (8,9)

In animals with cholestasis induced from methylated steroids, milk thistle has been shown to significantly restore bile production and bile outflow in less than 5 days. (19-21) However we do encorage "pre-conditioning" the liver with Liver Juice two weeks prior to any methylated oral steroid cycle, while continuing use throughout the entire cycle.



Liver Juice – The Timeless Miracle Worker

Liver Juice (milk thistle) has been used safely to treat various liver diseases for thousands of years. Out of the dozens of published scientific papers on milk thistle, no harmful side-effects have ever been found. (1-4)

It was nearly 2000 years ago when Pliney The Elder noted that milk thistle juice was excellent for “carrying off bile”. (29) I guess it appears he was right after all



Supplement Facts
Serving Size: 5cc (5mL oral syringe)

Servings per container: 50


Amount Per Serving %DV*


--------------------------------------------------------------------------------
Milk Thistle Extract (Silybum marianum) 500mg**

(standardized to 80% silymarin)


--------------------------------------------------------------------------------
Minimum total flavonolignans 400mg**


--------------------------------------------------------------------------------
Silybin 150mg**


--------------------------------------------------------------------------------
*Daily Value

**Daily Value not established


Other Ingredients: Other ingredients: Liqua-Vade Technology [Distilled water, exthoxylated sorbitan trioleate, dimethyl isosorbide, ethyl oleate, sorbitan monolaurate, ethoxylated mono and di-glycerides, medium chain triglycerides, grape spirits, sesame oil, phospholipid complex (phosphatidylcholine, lysophosphatidylcholine), glyceryl triacetate, tocopheryl acetate, hydroxyproply methylcellulose], malt syrup, natural almond flavor, sucralose, trisodium citrate, simethicone, potassium sorbate, sodium benzoate, citric acid†, sucrose†. † Used for food grade adhesive on syringe adapter
NOTICE:
No artificial color

This product is not intended to diagnose, treat, cure, or prevent any disease.


 
Blutarski

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Keep the general health products coming, not as sexy as the muscle building compounds but in the long run just as important.
 
flightposite

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whooohoooo :D :D liverjuice sounds tasty it would go good with some fava beans and chianti.
 
qwerty33

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will be using this on cycle and for pct. Also recommending to my friends in college for general health :)
 
Trauma1

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will be using this on cycle and for pct. Also recommending to my friends in college for general health :)
That's a good idea indeed. This very much can be utilized as a general health product.

- John
 
Trauma1

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This is our new Milk Thistle LV-based product. We have a very nice write-up to go along with this that will be posted up shortly. There is supportive evidence/studies showing Silymarin having the ability to reduce and even prevent instances of pharmacological-induced liver cholestasis (a potential dangerous effect of reduced ductal bile flow within the liver induced by methylated compounds). The night crew gets first crack at this one.

This is a GREAT addition of prevention for those looking for protection while on-cycle.

Get it now!

Click here for Liver Juice-LV!



Supplement Facts
Serving Size: 5cc (5mL oral syringe)

Servings per container: 50


Amount Per Serving %DV*


--------------------------------------------------------------------------------
Milk Thistle Extract (Silybum marianum) 500mg**

(standardized to 80% silymarin)


--------------------------------------------------------------------------------
Minimum total flavonolignans 400mg**


--------------------------------------------------------------------------------
Silybin 150mg**


--------------------------------------------------------------------------------
*Daily Value

**Daily Value not established


Other Ingredients: Other ingredients: Liqua-Vade Technology [Distilled water, exthoxylated sorbitan trioleate, dimethyl isosorbide, ethyl oleate, sorbitan monolaurate, ethoxylated mono and di-glycerides, medium chain triglycerides, grape spirits, sesame oil, phospholipid complex (phosphatidylcholine, lysophosphatidylcholine), glyceryl triacetate, tocopheryl acetate, hydroxyproply methylcellulose], malt syrup, natural almond flavor, sucralose, trisodium citrate, simethicone, potassium sorbate, sodium benzoate, citric acid†, sucrose†. † Used for food grade adhesive on syringe adapter
NOTICE:
No artificial color

This product is not intended to diagnose, treat, cure, or prevent any disease.


Bump! :D
 
Trauma1

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This is our new Milk Thistle LV-based product. We have a very nice write-up to go along with this that will be posted up shortly. There is supportive evidence/studies showing Silymarin having the ability to reduce and even prevent instances of pharmacological-induced liver cholestasis (a potential dangerous effect of reduced ductal bile flow within the liver induced by methylated compounds). The night crew gets first crack at this one.

This is a GREAT addition of prevention for those looking for protection while on-cycle.

Get it now!

Click here for Liver Juice-LV!



Supplement Facts
Serving Size: 5cc (5mL oral syringe)

Servings per container: 50


Amount Per Serving %DV*


--------------------------------------------------------------------------------
Milk Thistle Extract (Silybum marianum) 500mg**

(standardized to 80% silymarin)


--------------------------------------------------------------------------------
Minimum total flavonolignans 400mg**


--------------------------------------------------------------------------------
Silybin 150mg**


--------------------------------------------------------------------------------
*Daily Value

**Daily Value not established


Other Ingredients: Other ingredients: Liqua-Vade Technology [Distilled water, exthoxylated sorbitan trioleate, dimethyl isosorbide, ethyl oleate, sorbitan monolaurate, ethoxylated mono and di-glycerides, medium chain triglycerides, grape spirits, sesame oil, phospholipid complex (phosphatidylcholine, lysophosphatidylcholine), glyceryl triacetate, tocopheryl acetate, hydroxyproply methylcellulose], malt syrup, natural almond flavor, sucralose, trisodium citrate, simethicone, potassium sorbate, sodium benzoate, citric acid†, sucrose†. † Used for food grade adhesive on syringe adapter
NOTICE:
No artificial color

This product is not intended to diagnose, treat, cure, or prevent any disease.


Click on the link above for more information on our product in the write-up. This product really should be a staple for any guys looking to utilize and oral methylated compound.

- John
 
Trauma1

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I've added the full write-up to the first post, everyone.

- John
 
rulk22

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Great new addition. Im already ordering quit a bit of this Liver Juice, not only for pct, but general health as well. Thanks to Primordial Performance for the hard work, great efforts, and equally great products. And wow! I never gave it much thought of how much research and development goes into these products.
 
Trauma1

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Great new addition. Im already ordering quit a bit of this Liver Juice, not only for pct, but general health as well. Thanks to Primordial Performance for the hard work, great efforts, and equally great products. And wow! I never gave it much thought of how much research and development goes into these products.
Thank you, sir. :D
 
Trauma1

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This is our new Milk Thistle LV-based product. We have a very nice write-up to go along with this that will be posted up shortly. There is supportive evidence/studies showing Silymarin having the ability to reduce and even prevent instances of pharmacological-induced liver cholestasis (a potential dangerous effect of reduced ductal bile flow within the liver induced by methylated compounds). The night crew gets first crack at this one.

This is a GREAT addition of prevention for those looking for protection while on-cycle.

Get it now!

Click here for Liver Juice-LV!


Steroids for your Liver

We think Liver Juice is so awesome; it could be called Liver Steroids.

But of course, we didn’t want to give the product a bad name.

It appears that milk thistle does to the liver, what anabolic steroids to do the muscles. Milk thistle turns a weak liver to a strong liver (except milk thistle has zero side effects). (1-4)

Ironically, after a formal review of the most current scientific literature on milk thistle, it appears milk thistle has specific protective effects against anabolic/androgenic steroid induced liver toxicity. We will present new and exciting research later in this article.

What’s most disappointing (and damaging to milk thistles reputation) is that 90% of the milk thistle products on the market have super poor absorption at only about 8%. (5-14) Therefore, we had to go the extra mile and create a liquid formula that would actually get milk thistle where it needs to be -- in the liver.

Before I show you exactly how milk thistle works I want to tell you about our impressive accomplishment with our Liver Juice formula, and the break though delivery system. Read on



Meeting the challenge – Mr. Milk Thistle


Try to image mixing a handful of chalk into a glass of water, you would see it either sink to the bottom or precipitate to the top -- that’s pretty close to how well milk thistle mixes into a glass of water.

To show the exceptional solubility accomplished with the milk thistle in our Liver Juice, we went ahead and took a 5mL dose (500mg) of Liver Juice and mixed it into a glass of water. We then took 500mg of the exact same milk thistle extract used in our Liver Juice, and vigorously shook it into a glass of water. Then they sat for 12 hours



As you can see, the milk thistle in Liver Juice remained completely stable and molecularly dispersed in the liquid. The milk thistle powder alone simply crashed to the bottom of glass. (“crash” means to crystallize, separate or no longer be in solution -- aka, not be absorbed into the body)

BTW, what you just witnessed was the result of about 119 hours in the lab, and about 12 months of research.

Anyway, we managed to make a nice milk thistle formula... but listen to why this is so important...



Membrane Invagination

Obviously, milk thistle does not dissolve in water, and hardly dissolves in most oils. (7) This inability to dissolve means milk thistle is very difficult to be absorbed by the human body, since the larger particles cannot pass though the walls of the digestive tract. (5-8, 12) In fact, milk thistle extract alone only absorbs at a rate of about 8% in humans. (5-14)

Unless nutrients are dispersed to micro-particle size, they simply won't be absorbed by the intestines. In order to get the maximum amount of milk thistle absorbed into the body we had to accomplish 3 things when formulating Liver Juice -

1. Modify the Liqua-Vade delivery system so milk thistle can complexly dissolve.

2. Make sure it remains dissolved once mixed in an aqueous environment (such as the stomach).

3. Make it safe and acceptable for drinking.

We ended up accomplishing all 3 goals. But it certainly wasn’t easy.



Editors note: Some of you home chemistry buffs are probably thinking milk thistle could just dissolve into some basic solvent like alcohol or glycerin. That may accomplish the 1st goal, but as soon as those water soluble solvents become diluted in a glass of water they would lose their solvent capacity and that milk thistle would fall out of solution and crash right to the bottom of the glass, therefore putting milk thistle right back to where it started.


Liqua-Vade – Tailored for Mr. Milk Thistle


Because the milk thistle flavones are such stubborn little molecules, we had to custom tailor our Liqua-Vade delivery system just for Liver Juice. We used a precise ratio of 12 different pharmaceutical grade carriers, phospholipids and fatty esters to dissolve our high potency milk thistle into a fine homogenous solution (while managing to give it a nice sweet almond taste).

Rest assured, our Liqua-Vade delivery technology isn’t some hyped up sugar water. It’s based on Self-Emulsifying Drug Delivery System (SEDDS) science, which is backed by dozens of 3rd party human clinical trials and is currently one of the hottest research fields in modern day drug delivery (5-7)

Over the years there have been other attempts at enhancing delivery of milk thistle, however Liqua-Vade delivery technology (SEDDS) trumps them all. (5-14) Just take a look





Bile acids - Liver Cleaners

Bile acids are the liver’s detergents -- flowing through the cellular channels all throughout the liver.

There are dozens of different bile acids created by the liver, all of which are metabolites of cholesterol. Essentially, they are created to dissolve and mobilize toxic material and export it from the liver and into the intestines for excretion. Different bile acids are needed to dissolve and carry different toxins from the liver.

In general, bile acids are your friends. However, certain drugs (including methylated steroids) cause the liver to slow bile acid production, and create a bile acid insufficiency, as well as cause a build up in the hepatotoxic bile acids (15-23) This makes a mess, and causes the liver to get jammed up fast. If the liver gets clogged up enough where bile can no longer flow from the biliary channels, a condition develops known as reversible cholestasis. (the primary condition developed from methylated steroids and birth control use) (15-23)

Luckily this liver condition is reversible. If you have suffered some toxic effects from steroids (or other drugs) you still have a chance to turn it around for the better.


Bile Acid – The Doctors Choice

Bile acid is the drug of choice prescribed to anabolic steroids users admitted for drug induced cholestasis. The drug is known as Ursodiol -- a.k.a. ursodeoxycholic acid. This naturally occurring bile acid is known for its hydrophilic action and ability to detoxify the liver by cleaning out less hydrophilic bile acids, among other toxins such as methylated hormone metabolites. (19, 24-27)

Unfortunately, Ursodiol is an expensive prescription drug, and not easily obtainable.

As I mentioned earlier, there is new and exciting research on milk thistle that we are excited to present. Research has shown us milk thistle has the ability to increase production of this protective bile acid -- ursodeoxycholic acid (at the same relative dose delivered by Liver Juice) (18-23)


The West Side Liver Gang – Cleaning up the Trash

The main active ingredients in milk thistle are flavonolignans, known as silichristin, silidianin, isosilibinin, and the most biologically active player, silybin (Our milk thistle extract is standardized to 30% silybin). (1-4)

When these milk thistle flavonolignans enter the liver they don’t mess around. They immediately start circulating the liver to signal sluggish and under-producing liver cells to pick up the production of liver cleansing bile acids, esspecialy the hepatoprotective variety such as ursodeoxycholic acid. It appears that silybin stimulates Cyp7a1 and Cyp3a enzymes to encorage conversion of cholesterol towards protective and hydrophilic bile acids. (18-23)

Now here is the clincher...

Studies have shown that milk thistle can reverse the down-regulating effect on bile acid production even during the administration of methylated steroids. So when steroids are in the liver inhibiting production of the beneficial bile acids, milk thistle steps in and ramps up beneficial bile acid production while enhancing the export of built up toxins (and methylated steroids) from the liver. (18-23, 28)



Liver Juice - Quick to Battle

With our Liqua-Vade delivery system, the active milk thistle flavones will reach the liver fast. Once absorbed through the intestines the biologically active flavones are immediately carried into the liver, where they begin stimulating the liver cells to revive detoxifying bile acid production. (8,9)

In animals with cholestasis induced from methylated steroids, milk thistle has been shown to significantly restore bile production and bile outflow in less than 5 days. (19-21) However we do encorage "pre-conditioning" the liver with Liver Juice two weeks prior to any methylated oral steroid cycle, while continuing use throughout the entire cycle.



Liver Juice – The Timeless Miracle Worker

Liver Juice (milk thistle) has been used safely to treat various liver diseases for thousands of years. Out of the dozens of published scientific papers on milk thistle, no harmful side-effects have ever been found. (1-4)

It was nearly 2000 years ago when Pliney The Elder noted that milk thistle juice was excellent for “carrying off bile”. (29) I guess it appears he was right after all



Supplement Facts
Serving Size: 5cc (5mL oral syringe)

Servings per container: 50


Amount Per Serving %DV*


--------------------------------------------------------------------------------
Milk Thistle Extract (Silybum marianum) 500mg**

(standardized to 80% silymarin)


--------------------------------------------------------------------------------
Minimum total flavonolignans 400mg**


--------------------------------------------------------------------------------
Silybin 150mg**


--------------------------------------------------------------------------------
*Daily Value

**Daily Value not established


Other Ingredients: Other ingredients: Liqua-Vade Technology [Distilled water, exthoxylated sorbitan trioleate, dimethyl isosorbide, ethyl oleate, sorbitan monolaurate, ethoxylated mono and di-glycerides, medium chain triglycerides, grape spirits, sesame oil, phospholipid complex (phosphatidylcholine, lysophosphatidylcholine), glyceryl triacetate, tocopheryl acetate, hydroxyproply methylcellulose], malt syrup, natural almond flavor, sucralose, trisodium citrate, simethicone, potassium sorbate, sodium benzoate, citric acid†, sucrose†. † Used for food grade adhesive on syringe adapter
NOTICE:
No artificial color

This product is not intended to diagnose, treat, cure, or prevent any disease.


Bump. :439:
 
bulldogz

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Took first dose today and this stuff is not tasty at all...lol...so hope my liver likes it :D
 
bulldogz

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will liver juice have other flavors as well, maybe?
 
rulk22

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How about a larger size bottle of Liver Juice? Ive decided to use this year round.
 
Whacked

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Sorry in advance for the seemingly ignorant question.

I know PP is an advanced company with killer products :)


So, how is this product vastly superior to any other milk thistle product other than the LV technology delivering more thistle to the liver cells?

In essense, couldn't one just take more thistle as milk thistle as the stuff is pretty CHEAP?

In addition to that, and more importantly, why wouldnt PP use or ADD other superior hepatotoxic prevention ingredients (NAC/ALA (glutathione), Tauroursodeoxycholic acid, etc) as opposed to just milk thistle (albeit in superior delivery form) which has never even been really proven to help with STEROID-specific-induced liver damage, just basic liver disorders and regeneration/support . :confused:

Just curious. Thanks

Clin Toxicol (Phila). 2008 Jan;46(1):57-66.
Multivitamins and phospholipids complex protects the hepatic cells from androgenic-anabolic-steroids-induced toxicity.Pagonis TA, Koukoulis GN, Hadjichristodoulou CS, Toli PN, Angelopoulos NV.
Department of Endocrinology, Thessaly University Medical School, Larissa, Greece.

INTRODUCTION. Androgenic-anabolic-steroids (AAS)-induced hepatotoxicity typically occurs with C-17 alkylated oral agents abused by exercising individuals at clinically recommended doses. Injectable compounds appear to have the same risk for hepatotoxicity, but are applied in doses three to six times higher than clinically recommended. AAS users occasionally try to avoid the well-known hepatotoxic effects associated with the abuse of a multitude of AAS agents, by using the pharmaceutical agent compound N a phospholipid/vitamin preparation. PRIMARY OBJECTIVE. The investigation of the actual hepatoprotective effect of compound N against AAS-induced toxicity. METHODOLOGY. This was an observational cohort study of 320 athletes; 160 were AAS users and the other 160 were not abusing any substances. Of the 160 users, 44 were using AAS and compound N (group A), and 116 were using solely AAS (group B). The 160 athletes abstaining from substances abuse acted as controls (group C). All athletes were tested for alterations in serum levels of hepatic enzymes. Enzyme levels before the study's onset and after the end of the 8-week AAS regimes were compared among the three groups, in order to delineate the hepatoprotective effect of compound N. RESULTS. Prior to our research all groups showed normal values in all enzymes except creatine kinase (CK). After the 8-week period, CK levels were slightly lower in group A, but without variation in Groups B and C; gamma-Glutamyl Transferase (GT) levels remained normal. Groups A and C had no elevations in any of the enzymes, except CK, while in group B all enzymes' values were elevated above the normal range.The only factor differentiating AAS users in group A from those in group B was the use of compound N, thus the results being suggestive of the compound's detoxification effect. The severity of AAS abuse was positively associated with the degree of changes in all measured enzymes except GT and CK. CONCLUSIONS. Previous suggestions that serum hepatic enzyme elevations in exercising AAS abusers are connected to muscle fiber damage rather than the abuse itself, are contradicted by our results. Since all AAS abusing athletes were prone to exhibit elevations in enzymes' values, the mean values of group A were to be similar to those observed in group B, exceeding normal values. The group hepatic enzyme values of group B were significantly higher than the group C (control). Notably, group A did not have any statistically significant difference in the hepatic enzyme values compared to group C. The effect of exercise on these enzymes' elevations was ruled out by the comparability of training regimens and AAS toxicity was correlated to the severity of AAS abuse.

PMID: 17852158 [PubMed]
 
Trauma1

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Sorry in advance for the seemingly ignorant question.

I know PP is an advanced company with killer products :)


So, how is this product vastly superior to any other milk thistle product other than the LV technology delivering more thistle to the liver cells?

In essense, couldn't one just take more thistle as milk thistle as the stuff is pretty CHEAP?

In addition to that, and more importantly, why wouldnt PP use or ADD other superior hepatotoxic prevention ingredients (NAC/ALA (glutathione), Tauroursodeoxycholic acid, etc) as opposed to just milk thistle (albeit in superior delivery form) which has never even been really proven to help with STEROID-specific-induced liver damage, just basic liver disorders and regeneration/support . :confused:

Just curious. Thanks
I'll get back to answering this tonight when I have a bit more time. The whole issue here is multifactoral.

Nice study, though. However, this is really only addressing one dynamic issue of the big picture in relation to AAS use and hepatotoxic/intra-hepatic cholestatic events.
 
Whacked

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Hi T - any news?
 
Trauma1

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Hi T - any news?
I haven't forgotten my man. I've just been on baby duty all weekend, so my time is limited. I'll try to get to answering this by tomorrow night.

-John
 
Whacked

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Thanks T ;)
 
qwerty33

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just finished up my first bottle. great product
 
Eric Potratz

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Sorry in advance for the seemingly ignorant question.

I know PP is an advanced company with killer products :)


So, how is this product vastly superior to any other milk thistle product other than the LV technology delivering more thistle to the liver cells?

In essense, couldn't one just take more thistle as milk thistle as the stuff is pretty CHEAP?

In addition to that, and more importantly, why wouldnt PP use or ADD other superior hepatotoxic prevention ingredients (NAC/ALA (glutathione), Tauroursodeoxycholic acid, etc) as opposed to just milk thistle (albeit in superior delivery form) which has never even been really proven to help with STEROID-specific-induced liver damage, just basic liver disorders and regeneration/support . :confused:

Just curious. Thanks
Good questions.

You could super-dose standard milk thistle powder but you will probably end up with gastric upset since the body will have a hard time dispersing and digesting a ton of milk thistle powder.

We wanted to keep the formula basic. Other ingredients might have added other effects (side-effects) that might be undesirable to people. Milk thistle is pretty much side-effect free and compatible with just about anybody. We looked at incorporating the Tauroursodeoxycholic acid but it tastes like pure bile acid... and just wasnt an option for a liquid formula.

-Eric
 
rulk22

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Update. Instead of a bigger bottle im just goin to have a subscription to Liver Juice. I get a decent store credit for this also. So im using this as a regular supplement now, will Primordial Performance be coming out with more general health supplements?

I had another question. Mixing other Liqua-vade compounds with other Lv compounds ok? just putting it in a big worm shot and drink up. I only ask this so to make things easier, quicker and so on.
 
Whacked

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Thanks PP ;)

Good questions.

You could super-dose standard milk thistle powder but you will probably end up with gastric upset since the body will have a hard time dispersing and digesting a ton of milk thistle powder.

We wanted to keep the formula basic. Other ingredients might have added other effects (side-effects) that might be undesirable to people. Milk thistle is pretty much side-effect free and compatible with just about anybody. We looked at incorporating the Tauroursodeoxycholic acid but it tastes like pure bile acid... and just wasnt an option for a liquid formula.

-Eric
 
Eric Potratz

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Update. Instead of a bigger bottle im just goin to have a subscription to Liver Juice. I get a decent store credit for this also. So im using this as a regular supplement now, will Primordial Performance be coming out with more general health supplements?

I had another question. Mixing other Liqua-vade compounds with other Lv compounds ok? just putting it in a big worm shot and drink up. I only ask this so to make things easier, quicker and so on.
Yep, mixing LV products is fine.

-Eric
 
Eric Potratz

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So we would be able to take one worm shot of sd lv and derma lv in one glass?

That would be great if we could :)
Yeah. I actually prefer to take a full mouth of water and just fire the LV into the mouth and swallow.

-Eric
 

UKStrength

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I take all the shots in one go :) Make nice ****tail and down the hatch!
 

Hugo Danner

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Was planning on doing AI's Life Support pre/during/post SD cycle. Now I have a dilemma - Liver Juice or Life Support!? Liver Juice seems hands-down better for pure Milk Thistle delivery/efficiency. Life Support, however, offers both Red Yeast Rice (good for the cholesterol profile) and Hawthorne Berry (great for blood pressure issues). If I use both, then I would be OD'ing on Milk Thistle. What to do...what to do....
 

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