[thebigt]

i just read that taking trib products will negate the effect of nolva. any input of anything else to be avoided while on nolva would be appreciated. this is a real shocker to me as i regularly use a trib product on pct.

[TripDog]

Huh, mind providing a link to this.

[MuscleBound1337]

Yeah I read youtr post in another thread that said this and I was searching google looking for any evidence on this claim and couldn't find anyone else saying that..

I just started my PCT with nolva and am taking trib.. So I'd like to get to the bottom of this as soon as possible.

[thebigt]

Originally Posted by leetuser

Yeah I read youtr post in another thread that said this and I was searching google looking for any evidence on this claim and couldn't find anyone else saying that..

I just started my PCT with nolva and am taking trib.. So I'd like to get to the bottom of this as soon as possible.

i got this from a post by dinoii. my aunt has cancer and is taking tamox, on the instructions it said notify doctor of any herbal supplements you are taking as they may negate the effects of the tamoxifen, then i read a post by dinoii saying same thing. believe me guys, i am shocked that this is true. i use trib on almost every pct. what i am pissed about is if this is true, why haven't people got the word out to us.

[BigKrabbe]

I do not see how it possibly could. There is no way trib negates nolvadex, if anything nolva is the more powerful compound and would negate tribulus, but even that is not very propable. Tribulus is supposed to act by raising lh thus increasing free testosterone. Tribulus could potentially raise estrogen levels as well, but if anything nolvadex would just negate that effect of the trib. Just my .02 cents and most of that is my opinion, but there is plenty of studies backing up trib. I have never seen a study testing trib negating nolvadex but am on the search now!

[MuscleBound1337]

Well that's pretty standard for any prescription drug ,they want to know what all your taking incase there is any known problem. Just because it says to notify your doc of herbs ur taking doesn't mean any herb is going to negate the effects.. If you search for trib and nolca pct all you find is good reviews.. What did dinoii say? Have a link?

[thebigt]

Originally Posted by leetuser

Well that's pretty standard for any prescription drug ,they want to know what all your taking incase there is any known problem. Just because it says to notify your doc of herbs ur taking doesn't mean any herb is going to negate the effects.. If you search for trib and nolca pct all you find is good reviews.. What did dinoii say? Have a link?

i checked with dinoii, he says he can't recall saying trib has that effect, but says that dhea + nolva does= bad. maybe i got it wrong...thanks guys for setting me straight, i also use trib on pct.

[TripDog]

Originally Posted by thebigt

i checked with dinoii, he says he can't recall saying trib has that effect, but says that dhea + nolva does= bad. maybe i got it wrong...thanks guys for setting me straight, i also use trib on pct.

Dhea and nolva bad???? I seriously think you need to question your source.

[ohiostate2827]

can i just take nolva by itself?

[RenegadeRows]

Originally Posted by ohiostate2827

can i just take nolva by itself?

Yes.

[VINYL]

how about Divanol in pct (mass fx, activate etc etc) I heard that taking these in PCT is bad because it actually just increases your free test and not you actual test, and your body reacts by having some shutdown. Has anyone ever heard this before and how much truth to this is there?

[TripDog]

Originally Posted by VINYL

how about Divanol in pct (mass fx, activate etc etc) I heard that taking these in PCT is bad because it actually just increases your free test and not you actual test, and your body reacts by having some shutdown. Has anyone ever heard this before and how much truth to this is there?

I recall Dr.D saying around week 3 its ok to start activate, but im not sure how this stands today though.

[jasonschaffin]

Originally Posted by TripDog

Dhea and nolva bad???? I seriously think you need to question your source.

Dinoiii is a pretty smart dude. From what I can tell he deals w/all sorts of people coming off different AAS cycles and has lab reports on many different drugs used to bring the HPTA back. I believe that he says that the DHEA has some sort of estrogen activity that could negate/lower the effect of the SERM. I don't know at what dose he says this happens or to exactly what effect. If we can get him over here I'm sure he could explain 1,000,000x better. Or you could ask him in his own subforum, probably the easiest way to a good answer.

[jasonschaffin]

I posted this many moons ago and no one ever responded. I can't see how DHEA could be good for PCT though.

DHEA in PCT?

--------------------------------------------------------------------------------

: Mol Cell Endocrinol. 2003 May 30;203(1-2):13-23. Links
Evidence that dehydroepiandrosterone, DHEA, directly inhibits GnRH gene expression in GT1-7 hypothalamic neurons.Cui H, Lin SY, Belsham DD.
Department of Physiology, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Medical Sciences Building 3247A, 1 King's College Circle, Toronto, ON, Canada M5S 1A8.

Dehydroepiandrosterone (DHEA) has been reported to have diverse effects on overall physiology, although its mechanism of action and specific receptor are not yet known. We have used the immortalized, clonal GT1-7 hypothalamic neurons to study DHEA effects on gonadotropin-releasing hormone (GnRH) gene expression. DHEA (10(-4) M) downregulates GnRH transcription by 39, 70 and 83% at 24, 36, and 48 h, respectively, while DHEA-sulphate had no effect. Hydroxyflutamide a specific androgen receptor (AR) antagonist, and cyproterone acetate or trilostane, both inhibitors of 3 beta-hydroxysteroid dehydrogenase/delta 4,5 isomerase, the rate-limiting enzyme for the conversion of DHEA to sex steroids, did not affect the ability of DHEA to downregulate GnRH gene expression. We found that GT1-7 cells did not express aromatase, thereby precluding conversion to estrogen. Analysis of [(14)C] DHEA metabolism by thin layer chromatography indicates that the main metabolites produced are 7 alpha- and 7 beta-hydroxy DHEA, and 7-oxo DHEA, although these steroids were not able to repress GnRH gene expression alone. Cell viability studies indicated that the transcriptional repression observed is not due to GT1-7 cell death. Interestingly, SV40 T-antigen mRNA levels, under the control of 2.3 kb of the rat GnRH gene 5' regulatory region, are also repressed by DHEA. Our studies indicate that DHEA has direct effects on GnRH transcription that appear to be unique from those observed after conversion to other steroidogenic compounds.

PMID: 12782399 [PubMed - indexed for MEDLINE]