Lodhra (Bark) Extract

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  1. Lodhra (Bark) Extract


    Lodhra Bark Extract
    Aka
    Symplocos Racemosa Extract



    Phosphodiesterase (PDE) Inhibition

    PDE inhibitors are used clinically for erectile dysfunction (PDE5i like Viagra), weight loss, and bronchodilation/asthma treatment.

    Symplocos Racemosa is one of nature’s most well-documented phosphodiesterase inhibitors. Phosphodiesterase is the enzyme responsible for breaking down cyclic-AMP (cAMP). cAMP is a second messenger that has beneficial effects like improved fat loss, increased muscle mass, improved thyroid function, and improved steroidogenesis. Indeed, the very reason forskolin works is because it increases levels of cAMP in the body by increasing levels of the enzyme that creates cyclic AMP.

    A simplified model:

    Enzyme A -> cAMP pool of the body -> Enzyme B

    Enzyme A is creating more cAMP for the aforementioned benefits. This is the enzyme that forskolin increases, resulting in the well-documented effects on human body composition.
    Enzyme B is breaking down cAMP and working against enzyme A. Enzyme B is known as phosphodiesterase (PDE). Symplocos racemosa contains PDE inhibitors, so levels of Enzyme B decrease and levels of cAMP increase. The net result is increased levels of cAMP.

    http://www.ncbi.nlm.nih.gov/pubmed/15643556
    http://onlinelibrary.wiley.com/doi/1...nticated=false
    http://europepmc.org/abstract/MED/12...VmR5GtJexNnE.4


    The specific PDE they tested against in these studies was PDE1, but this does not mean that Lodhra bark is not active against other PDE isoforms. PDE1 inhibition is a mechanism shared by selegiline (Deprenyl), but its main documented role is enhanced pulmonary function, improved energy levels, and increased vasodilation in response to nitric oxide (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650605/).



    Hormonal Effects

    Aside from increasing cAMP which increases steroidogenesis, Lodhra also increases LH/FSH (http://www.ncbi.nlm.nih.gov/pubmed/15261983) and was effective in treating a murine model analogous to secondary infertility. In males, LH is known to stimulate testosterone production while FSH nourishes developing sperm.


    Complementary Effects with Arachidonic Acid (ArA)


    ArA has three primary metabolites: prostaglandins (associated with muscle accretion and vasodilation), thromboxanes (associated with blood clotting; inhibited by carnitines or aspirin), and leukotrienes (associated with constriction of smooth muscle, such as bronchoconstriction). The latter two effects are typically considered unfavorable.
    Lodhra Bark is a lipoxygenase inhibitor, preventing the conversion of ArA to leukotrienes. This leaves more ArA available to be converted to prostaglandins or thromboxanes, the latter of which can be inhibited by methods stated above.

    http://www.ncbi.nlm.nih.gov/pubmed/15938197


  2. Liver Support



    Lodhra Bark extract has been shown to reverse markers of liver damage and even change the histology (cell structure) of the liver from a diseased state to a healthy state.

    http://www.ncbi.nlm.nih.gov/pubmed/22022156

    The authors concluded that Lodhra has “has potential clinical applications for treatment of liver diseases.”


    Wound Healing



    Lodhra is one of few plants that has been deemed effective in the healing of wounds, both internally (ulcers, etc) and externally.

    http://www.ncbi.nlm.nih.gov/pubmed/15866825


    Gastrointestinal Health



    Lodhra has been traditionally used as an anti-diarrheal and for preventing “looseness of the bowels.” (http://books.google.com/books?****2Hy...cemosa&f=false). It also seems to have a curative effect on GI ulcers that is comparable to clinical drugs.
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  3. Is there anything else regarding the hormonal effects? That study is kind of meh.
    Black Lion Research Rep

  4. Yes indeed. I didn't cite them all, but it has several human trials showing normalization of menstrual periods/cycles and such, as well as helping with infertility. I didn't cite them because people get confused about studies in women, but the bottom line is the same: increased FSH and LH release. If you're not a woman, this doesn't result in increased estrogen; it results in increased testosterone. Regardless, this compound stands out to me for the large amount of data on PDE inhibition.

  5. Quote Originally Posted by mr.cooper69 View Post
    Yes indeed. I didn't cite them all, but it has several human trials showing normalization of menstrual periods/cycles and such, as well as helping with infertility. I didn't cite them because people get confused about studies in women, but the bottom line is the same: increased FSH and LH release. If you're not a woman, this doesn't result in increased estrogen; it results in increased testosterone. Regardless, this compound stands out to me for the large amount of data on PDE inhibition.
    Sounds like clomid in the way it would help womens fertility, but interesting you said it will not increase estrogen... Why not?
    Owner; Human Performance Science (HPS)
    HPSSupps.com
    Instagram.com/HPScience
    Facebook.com/HPScience
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  6. Quote Originally Posted by chedapalooza View Post
    Sounds like clomid in the way it would help womens fertility, but interesting you said it will not increase estrogen... Why not?
    This is why I didn't want to get into it, but FSH/LH increase estrogen in women. They are gonadotropins. In men, they increase our gonadal hormone: testosterone.

  7. I'm on now going to take out a mortgage and buy lots of ABE.
    ...::: Olympus Labs Athlete & Representative :::...
    Crossfit - DEMIGOD -

  8. Quote Originally Posted by EBF_2356 View Post
    I'm on now going to take out a mortgage and buy lots of ABE.
    PES/AS is taking 2014 by storm. We haven't even seen the 6 new products from analyzed.
    Owner; Human Performance Science (HPS)
    HPSSupps.com
    Instagram.com/HPScience
    Facebook.com/HPScience

  9. Quote Originally Posted by chedapalooza View Post
    PES/AS is taking 2014 by storm. We haven't even seen the 6 new products from analyzed.
    And who said they're just bulks? Get ready for some formulas!

  10. Quote Originally Posted by chedapalooza View Post
    PES/AS is taking 2014 by storm.
    Yes sir.
    PEScience Representative
    http://pescience.com/insider
    http://selectprotein.com
  11. AnabolicMinds Site Rep
    Driven2lift's Avatar

    Looks fantastic, knew it would be so the order was already placed, awaiting delivery once again.

    Question Coop, as.a PDE inhibitor is there any recommendation here for use alongside nitrates/NO products?
    PEScience Representative; Use the code Driven for 30% off at pescience.com

  12. Quote Originally Posted by chedapalooza View Post
    PES/AS is taking 2014 by storm. We haven't even seen the 6 new products from analyzed.
    Quote Originally Posted by EBF_2356 View Post
    I'm on now going to take out a mortgage and buy lots of ABE.
    think though twice may be on the leave off windflood insuring
    "To your wife you should kiss try today"-Touey

    Brotato's bark brings shakes to the pups in the yard

  13. Whoa...time out....what does AS have in store for us in the very near future?????

    I know that PES is doing it big, no surprise there but I haven't heard about what AS is planning on doing....

  14. Oh yeah, thanks Coop for that write-up. Good stuff!

  15. We have a lot up our sleeve at the moment.
    PEScience Representative
    http://pescience.com/insider
    http://selectprotein.com

  16. Quote Originally Posted by cbsharpe View Post
    Whoa...time out....what does AS have in store for us in the very near future?????

    I know that PES is doing it big, no surprise there but I haven't heard about what AS is planning on doing....
    3 new product almost ready for release!
    The Historic PES Legend

  17. Quote Originally Posted by DAdams91982 View Post
    3 new product almost ready for release!
    Awesome...thanks man!

  18. Quote Originally Posted by bdcc View Post
    We have a lot up our sleeve at the moment.
    Name:  images (100).jpg
Views: 4454
Size:  11.0 KB i want the one with two bdcc
    "To your wife you should kiss try today"-Touey

    Brotato's bark brings shakes to the pups in the yard

  19. Quote Originally Posted by Driven2lift View Post

    Question Coop, as.a PDE inhibitor is there any recommendation here for use alongside nitrates/NO products?
    Bumping
    Owner; Human Performance Science (HPS)
    HPSSupps.com
    Instagram.com/HPScience
    Facebook.com/HPScience

  20. Can't wait to give this new ABE + ArA a go!
    PEScience Representative
    http://www.pescience.com/insider
    Instagram: kylebayne23

  21. Sounds awsome coop!

    So badly wanna use ARA but hate reading stuff like carcinogenic and cancer etc when it comes to ARA. Sighs...

    If there's nothing to worry about I'd sure love to know 100%. Especially since the new ABE will work well Combined with ARA..

    Why don't you guys come out with your own ARA supplement? Would be great selling stacked with the new ABE.

  22. Quote Originally Posted by Johnold View Post
    Sounds awsome coop! So badly wanna use ARA but hate reading stuff like carcinogenic and cancer etc when it comes to ARA. Sighs... If there's nothing to worry about I'd sure love to know 100%. Especially since the new ABE will work well Combined with ARA.. Why don't you guys come out with your own ARA supplement? Would be great selling stacked with the new ABE.
    The only reason you should worry about the cancer warning is if you've been diagnosed with it or possibly have had a family history of cancer.

    Read the first few posts in here:

    Arachidonic Acid and Cancer. (X-Factor)
    PEScience Representative
    http://www.pescience.com/insider
    Instagram: kylebayne23

  23. It's that initial scare when you read about a bodybuilding supplement that has the C word thrown around it like nothing.

  24. This is the ingredient in compound 20 yeah?
    ...::: Olympus Labs Athlete & Representative :::...
    Crossfit - DEMIGOD -

  25. Quote Originally Posted by Johnold View Post
    It's that initial scare when you read about a bodybuilding supplement that has the C word thrown around it like nothing.
    my friend if you feel uncomfortable in any way leave off taking "whatever" it will in the long run make not much difference natty sups. eat train sleep...admit I have my sup. I like very much when uncomfortable on one simply I leave off taking it.

    reality is tune in what you feel is right for you

    and I promise with all the sups. out there you will find some indeed right for you
    "To your wife you should kiss try today"-Touey

    Brotato's bark brings shakes to the pups in the yard
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