Benadryl (diphenhydramine) aids recovery? - AnabolicMinds.com

Benadryl (diphenhydramine) aids recovery?

Page 1 of 2 12 Last
  1. Screwtape's Avatar
    Join Date
    Dec 2007
    Posts
    215
    Rep Power
    195

    Reputation

    Benadryl (diphenhydramine) aids recovery?


    Recently I have been taking 50mg of benadryl before bed to prevent the down-regulation of the beta-2 receptor from ephedrine and I have noticed that my muscular recovery seems to have improved. I am wondering about how benadryl could improve recovery. I would guess that it may be due to a reduction or inhibition of histamine-induced cortisol secretion (histamine has been shown to enhance secretion of ACTH and cortisol);

    Histamine-induced cortisol secretion from bovine a...[Jpn J Pharmacol. 1997] - PubMed Result

    (WO/2007/076140) TREATMENT METHODS EMPLOYING HISTAMINE H3 RECEPTOR ANTAGONISTS, INCLUDING BETAHISTINE

    Has anyone else experienced this?

  2. CryingEmo's Avatar
    Join Date
    Dec 2006
    Posts
    3,080
    Rep Power
    1635

    Reputation

    I use it with valerian root and melatonin for sleep. Didn't know it had anothe benifits.
  3. thesinner's Avatar
    Join Date
    Apr 2006
    Age
    28
    Posts
    10,063
    Rep Power
    11889

    Reputation

    antihistamines can also lower testosterone levels

    your improved recovery is due to improved sleep
    Athletic Xtreme Rep
    Bob@athleticxtreme.com
    IFFI
    Ask me about the Athletic Xtreme Product Line
    •   
       

  4. nattydisaster's Avatar
    Stats
    6'0"  0 lbs.
    Join Date
    Mar 2008
    Posts
    10,154
    Rep Power
    3183268

    Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation

    melatonin and ZMA and valerian
  5. RedwolfWV's Avatar
    Stats
    5'10"  185 lbs.
    Join Date
    Dec 2005
    Age
    50
    Posts
    3,258
    Rep Power
    1986

    Reputation

    I'm with Sinner... I bet its due to better/deeper sleep.
  6. CryingEmo's Avatar
    Join Date
    Dec 2006
    Posts
    3,080
    Rep Power
    1635

    Reputation

    I'll tell you one thing:

    Nothing, absolutely nothing beats good sleep. You can take all the stims and crap you want, but sleep >>>>>>>>>>> everything when it comes to feeling good, having energy, and recovery.
  7. atjnutrition2's Avatar
    Stats
    5'11"  195 lbs.
    Join Date
    Apr 2008
    Posts
    609
    Rep Power
    383

    Reputation

    Benadryl is an antihistamine which inhibits the H1 receptors. This action causes a decrease in smooth muscle swelling, (Ie. the muscles lining your airways and blood vessels.) and itchiness. Both of which occur in an allergic reaction. In profound cases overstimulation of the H1 receptors leads to a narrowing of the airway to the point of suffocation.

    I can't see there being any effect of benadryl which would aid in muscle recovery. I have to agree with those on here who said ithat your results was due to better sleep.
  8. thesinner's Avatar
    Join Date
    Apr 2006
    Age
    28
    Posts
    10,063
    Rep Power
    11889

    Reputation

    Quote Originally Posted by atjnutrition2 View Post
    Benadryl is an antihistamine which inhibits the H1 receptors. This action causes a decrease in smooth muscle swelling, (Ie. the muscles lining your airways and blood vessels.) and itchiness. Both of which occur in an allergic reaction. In profound cases overstimulation of the H1 receptors leads to a narrowing of the airway to the point of suffocation.

    I can't see there being any effect of benadryl which would aid in muscle recovery. I have to agree with those on here who said ithat your results was due to better sleep.
    yeah dude. diphenhydramine can be some nasty stuff at high doses. Gets you high, and puts you in a VERY dangerous condition. I knew some kids in high school who were sent to the hospital after taking a bottle of benedryl each.
    Athletic Xtreme Rep
    Bob@athleticxtreme.com
    IFFI
    Ask me about the Athletic Xtreme Product Line
  9. atjnutrition2's Avatar
    Stats
    5'11"  195 lbs.
    Join Date
    Apr 2008
    Posts
    609
    Rep Power
    383

    Reputation

    not trying to hijack the thread--but dextromethorphan is another terrible one kids are using.
  10. thesinner's Avatar
    Join Date
    Apr 2006
    Age
    28
    Posts
    10,063
    Rep Power
    11889

    Reputation

    Quote Originally Posted by atjnutrition2 View Post
    not trying to hijack the thread--but dextromethorphan is another terrible one kids are using.
    Mmmm Robitussin. That was my favorite cough syrup when I was younger.
    Athletic Xtreme Rep
    Bob@athleticxtreme.com
    IFFI
    Ask me about the Athletic Xtreme Product Line
  11. Trauma1's Avatar
    Stats
    5'11"  220 lbs.
    Join Date
    Feb 2006
    Age
    35
    Posts
    15,425
    Rep Power
    57339

    Reputation

    Quote Originally Posted by thesinner View Post
    yeah dude. diphenhydramine can be some nasty stuff at high doses. Gets you high, and puts you in a VERY dangerous condition. I knew some kids in high school who were sent to the hospital after taking a bottle of benedryl each.
    Being in the medical profession, I can honestly tell you it's absolutely amazing that benadryl is over the counter. There is a medication called "atarax" or "vistaril" which is literally the same thing, however it's controlled and by prescription administration only. Unreal man. The benadryl hangover is aweful to some people. I will say though, benadryl has its place overall.

    I think what most people don't realize is that benadryl is a parasympathetic inhibitor(Autonomic Nervous system). Basically, that means it can and will increase your heart rate and blood pressure by inhibiting the parasympathetic response. This in itself is bad for many people especially with pre-existing medical conditions of cardiac nature(WPW: Wolf Parkinson's White Syndrome to be exact....or really an re-entry mechanism disease of the heart)

    Benadryl is very often prescribed as a sleep aid for many people. Hell, atarax is prescribed for anti-anxiety issues.....and that's basically like taking a benadryl.

    Evolutionary Muse - Inspire to Evolve
    Legendary

  12. nycste's Avatar
    Stats
    6'0"  250 lbs.
    Join Date
    Dec 2006
    Posts
    3,174
    Rep Power
    1689

    Reputation

    Quote Originally Posted by Trauma1 View Post
    Being in the medical profession, I can honestly tell you it's absolutely amazing that benadryl is over the counter. There is a medication called "atarax" which is literally the same thing that is controlled and by prescription administration. Unreal man. The benadryl hangover is aweful to some people. I will say though, benadryl has its place overall.

    I think what most people don't realize is that benadryl is a para-sympathetic inhibitor. Basically, that means it can and will increase your heart rate and blood pressure by inhibiting the para-sympathetic response. This in itself is bad for many people especially with pre-existing medical conditions of cardiac nature(WPW: Wolf Parkinson's White Syndrome to be exact.)

    Benadryl is very often prescribed as a sleep aid for many people. Hell, atarax is prescribed for anti-anxiety issues.....and that's basically like taking a benadryl.

    nice posting, plz give us more info on sleep aids and everything master !
  13. Trauma1's Avatar
    Stats
    5'11"  220 lbs.
    Join Date
    Feb 2006
    Age
    35
    Posts
    15,425
    Rep Power
    57339

    Reputation

    Quote Originally Posted by nycste View Post
    nice posting, plz give us more info on sleep aids and everything master !

    Where have you been bud?

    Evolutionary Muse - Inspire to Evolve
    Legendary

  14. atjnutrition2's Avatar
    Stats
    5'11"  195 lbs.
    Join Date
    Apr 2008
    Posts
    609
    Rep Power
    383

    Reputation

    Trauma--just curious...in what way are you in the medical field. Been a firefighter/medic for 11 years.
  15. Trauma1's Avatar
    Stats
    5'11"  220 lbs.
    Join Date
    Feb 2006
    Age
    35
    Posts
    15,425
    Rep Power
    57339

    Reputation

    Quote Originally Posted by atjnutrition2 View Post
    Trauma--just curious...in what way are you in the medical field. Been a firefighter/medic for 11 years.
    Emergency Room nurse for almost 8 years.....most of it in a trauma setting....thus the name.

    Evolutionary Muse - Inspire to Evolve
    Legendary

  16. atjnutrition2's Avatar
    Stats
    5'11"  195 lbs.
    Join Date
    Apr 2008
    Posts
    609
    Rep Power
    383

    Reputation

    Figured something like that. Thanks for all you guys do, truly is you guys that keep ER's running.
  17. Trauma1's Avatar
    Stats
    5'11"  220 lbs.
    Join Date
    Feb 2006
    Age
    35
    Posts
    15,425
    Rep Power
    57339

    Reputation

    Quote Originally Posted by atjnutrition2 View Post
    Figured something like that. Thanks for all you guys do, truly is you guys that keep ER's running.
    And like wise my friend. I have many fire/medic buddies. You guys equally do an amazing job in what you do. My dad was a fireman when we lived in CT for many years.....i wanted to do it, but i can't do heights bro haha. The healthcare system works pretty well when there are competent people at all ends of the spectrum.

    Evolutionary Muse - Inspire to Evolve
    Legendary

  18. arizonanewbie's Avatar
    Stats
    5'8"  186 lbs.
    Join Date
    Feb 2008
    Age
    35
    Posts
    210
    Rep Power
    186

    Reputation

    I can speak from experience that dextromethorpan is no joke - highly hallucinogenic. I mean like mushrooms or acid.
  19. Trauma1's Avatar
    Stats
    5'11"  220 lbs.
    Join Date
    Feb 2006
    Age
    35
    Posts
    15,425
    Rep Power
    57339

    Reputation

    Quote Originally Posted by arizonanewbie View Post
    I can speak from experience that dextromethorpan is no joke - highly hallucinogenic. I mean like mushrooms or acid.
    I find it hard to believe that anything outside peyote or PCP even remotely comes close to a good acid trip, however dextromethorphan has been known to cause hallucinations in large doses.

    Evolutionary Muse - Inspire to Evolve
    Legendary

  20. thesinner's Avatar
    Join Date
    Apr 2006
    Age
    28
    Posts
    10,063
    Rep Power
    11889

    Reputation

    Mescaline!!! Call it by the name of the compound, not the cactus it is often found in.


    There's a whole plethora of ergot alkaloids (i.e. LSD, Ergoline, etc.).
    Athletic Xtreme Rep
    Bob@athleticxtreme.com
    IFFI
    Ask me about the Athletic Xtreme Product Line
  21. Trauma1's Avatar
    Stats
    5'11"  220 lbs.
    Join Date
    Feb 2006
    Age
    35
    Posts
    15,425
    Rep Power
    57339

    Reputation

    Quote Originally Posted by thesinner View Post
    Mescaline!!! Call it by the name of the compound, not the cactus it is often found in.


    There's a whole plethora of ergot alkaloids (i.e. LSD, Ergoline, etc.).
    I know!!! I'm at work and not much time to type.

    Lysergic Acid Diethylamide FTW.

    Evolutionary Muse - Inspire to Evolve
    Legendary

  22. thesinner's Avatar
    Join Date
    Apr 2006
    Age
    28
    Posts
    10,063
    Rep Power
    11889

    Reputation

    Quote Originally Posted by Trauma1 View Post
    I know!!! I'm at work and not much time to type.

    Lysergic Acid Diethylamide FTW.
    yay dopamine!

    (or in the case of LSD, dopamine, adrenaline, seratonin, and probably some glutamate as well. )
    Athletic Xtreme Rep
    Bob@athleticxtreme.com
    IFFI
    Ask me about the Athletic Xtreme Product Line
  23. mathis50262's Avatar
    Stats
    5'10"  191 lbs.
    Join Date
    Mar 2008
    Age
    31
    Posts
    727
    Rep Power
    442

    Reputation

    Ya that **** can mess you up! I have random allergic reactions like once every 2 years, use to think it was from peanuts, but really not sure. Usually just after onset I have to drink a bottle of benadryl and not have to go to the hospital. My eyes swell completly closed, and I break out in rashes, and can feel my airway constricting! The stuff saves my life! But after you drink a bottle, your are really messed up!
  24. Trauma1's Avatar
    Stats
    5'11"  220 lbs.
    Join Date
    Feb 2006
    Age
    35
    Posts
    15,425
    Rep Power
    57339

    Reputation

    Quote Originally Posted by mathis50262 View Post
    Ya that **** can mess you up! I have random allergic reactions like once every 2 years, use to think it was from peanuts, but really not sure. Usually just after onset I have to drink a bottle of benadryl and not have to go to the hospital. My eyes swell completly closed, and I break out in rashes, and can feel my airway constricting! The stuff saves my life! But after you drink a bottle, your are really messed up!

    You should also keep a histamine-2 blocker around the house such as, pepcid(famotidine), zantac(ranitidine), or tagamet(cimetidine). They also assist in blocking the histamine cascade that leads to full blown anaphylaxis. Benadryl and an H-2 blocker together can save your life.

    Evolutionary Muse - Inspire to Evolve
    Legendary

  25. atjnutrition2's Avatar
    Stats
    5'11"  195 lbs.
    Join Date
    Apr 2008
    Posts
    609
    Rep Power
    383

    Reputation

    Quote Originally Posted by Trauma1 View Post
    You should also keep a histamine-2 blocker around the house such as, pepcid(famotidine), zantac(ranitidine), or tagamet(cimetidine). They also assist in blocking the histamine cascade that leads to full blown anaphylaxis. Benadryl and an H-2 blocker together can save your life.
    For some reason our EMS chief decided to take promethazine off of our trucks. Great H2 blocker, also was outstanding when pushing iv pain meds.
  26. jmh80's Avatar
    Stats
    5'10"  180 lbs.
    Join Date
    Mar 2004
    Age
    34
    Posts
    8,110
    Rep Power
    9661

    Reputation

    Trauma,
    Got a question on NVE's 7-phenyl stack. Someone on another board said there was a really strong stim in the mix of PEA-type molecules.

    Can you take a look at the ingrediants and let me know what you think?

    Thanks.
  27. mathis50262's Avatar
    Stats
    5'10"  191 lbs.
    Join Date
    Mar 2008
    Age
    31
    Posts
    727
    Rep Power
    442

    Reputation

    Hey thanks trama for the post, I'm going to have to look in to that! What I really need to do is just get myself a damn epi kit!
  28. Trauma1's Avatar
    Stats
    5'11"  220 lbs.
    Join Date
    Feb 2006
    Age
    35
    Posts
    15,425
    Rep Power
    57339

    Reputation

    Quote Originally Posted by mathis50262 View Post
    Hey thanks trama for the post, I'm going to have to look in to that! What I really need to do is just get myself a damn epi kit!
    Without a doubt man. Having an epi pen is by FAR the most important tool to utilize during acute anaphylaxis. Please do yourself a favor and have one on you at all times as well as somewhere like you vehicle in case of an emergency. Having the other stuff around is just an added bonus.

    Evolutionary Muse - Inspire to Evolve
    Legendary

  29. Trauma1's Avatar
    Stats
    5'11"  220 lbs.
    Join Date
    Feb 2006
    Age
    35
    Posts
    15,425
    Rep Power
    57339

    Reputation

    Quote Originally Posted by jmh80 View Post
    Trauma,
    Got a question on NVE's 7-phenyl stack. Someone on another board said there was a really strong stim in the mix of PEA-type molecules.

    Can you take a look at the ingrediants and let me know what you think?

    Thanks.
    I'll look into it J and get back to you.

    Evolutionary Muse - Inspire to Evolve
    Legendary

  30. jmh80's Avatar
    Stats
    5'10"  180 lbs.
    Join Date
    Mar 2004
    Age
    34
    Posts
    8,110
    Rep Power
    9661

    Reputation

    Thanks bruh.
  31. thesinner's Avatar
    Join Date
    Apr 2006
    Age
    28
    Posts
    10,063
    Rep Power
    11889

    Reputation

    Acacia Rigidula (herb in 7-phenyl) is a natural source of amphetamine and methamphetamine (among other phenethylamines), according to a study done in 1998. Looking for the actual study, but not finding.
    Athletic Xtreme Rep
    Bob@athleticxtreme.com
    IFFI
    Ask me about the Athletic Xtreme Product Line
  32. thesinner's Avatar
    Join Date
    Apr 2006
    Age
    28
    Posts
    10,063
    Rep Power
    11889

    Reputation
    Athletic Xtreme Rep
    Bob@athleticxtreme.com
    IFFI
    Ask me about the Athletic Xtreme Product Line
  33. wrkn4bigrmusles's Avatar
    Stats
    5'11"  206 lbs.
    Join Date
    Jan 2006
    Age
    35
    Posts
    708
    Rep Power
    460

    Reputation

    Question.. for those who use the benedryl after using clen or ephedrine, do you come off the products totally when trying to reenergize your receptors?

    Curious cause Im ceasing all supplementation and getting my body back to normal
  34. CaponeCEO's Avatar
    Stats
    5'10"  180 lbs.
    Join Date
    Aug 2007
    Age
    33
    Posts
    694
    Rep Power
    457

    Reputation

    Better sleep equals better recovery....period

    When you sleep your body enters recovery mode. Recovery mode is also known as protein-synthesis, the coversion of proteins into muscle for the purpose of regeneration of the used muscle from the human workday, or as we do our workouts in the gym. Benedry helps this process because it causes a deeper sleep due to its lethargy side effects, and its anti-cholenergic properties. When you are in deep sleep your REM levels are at their fastest/highest. REMS trigger protein-synthesis. Which is why in the body building world we stress good amounts of sleep, and to not sleep is virtually wasting your workout. Ever wonder why we need those awesome power naps during the day when we really push ourselves at the gym?...(even though most of us working people cant afford a noontime nap) Getting good sleep for recovery is why GHB was so big in the workout world. Hope this helps.
  35. ari4216's Avatar
    Stats
    5'10"  212 lbs.
    Join Date
    Mar 2008
    Posts
    2,093
    Rep Power
    0

    Reputation

    get the liquid benadryl and not the tablets, less groginess and better onset of delivery

    so wait why do people take benadryl and ephedrine together?
  36. conwict's Avatar
    Stats
    6'0"  200 lbs.
    Join Date
    Sep 2008
    Posts
    281
    Rep Power
    214

    Reputation

    I, too, have been taking 6mg melatonin and 50mg diphenhydramine before bed. Found it in a single-dose gel-cap...

    I like it to keep a regular sleep schedule. I would agree that the reason you're likely experiencing better recovery is because your sleep quality has increased.

    Edit: the diphen is the only thing in the gel-cap, btw.
  37. mrchristian's Avatar
    Stats
    6'3"  215 lbs.
    Join Date
    Apr 2008
    Age
    33
    Posts
    779
    Rep Power
    468

    Reputation

    I dont understand what the benefit of taking benedryl when using ephedrine is.
  38. Screwtape's Avatar
    Join Date
    Dec 2007
    Posts
    215
    Rep Power
    195

    Reputation

    Quote Originally Posted by mrchristian View Post
    I dont understand what the benefit of taking benedryl when using ephedrine is.
    I've heard this referred to as the 'Coastguard Cocktail', because members of the Coastguard would take diphenhydramine to ward off sea sickness and a dose of ephedrine to counter the drowsiness caused by the diphenhydramine.

    For athletes using ephedrine, taking diphenhydramine separately can help stop the down-regulation of the beta-adrenergic receptors, which would result in tolerance to ephedrine.
  39. Foolish's Avatar
    Join Date
    Oct 2008
    Posts
    14
    Rep Power
    80

    Reputation

    This is the reason people take diphenhydramine with ephedrine:

    Ketotifen has some proof to show it upregulates B2 adrenergic receptors, the same receptors clen acts on, as a result, people will run it with clen to increase/prolong the effects.

    Now here's where the bro logic kicks in:

    Since Keto is an antihistamine then all antihistamines must upregulate b2 receptors-->Ephedrine effects beta receptors/causing an eventual down regulation-->Using diphenhydramine will prolong/increase the effects of ephedrine.

    Problem is, ephedrine effects a lot of adrenoreceptors, it is not selective like clen is. With the keto/benadryl deal, people are confusing correlation with causation, I can not however say that this doesn't work, just that I haven't seen any actual proof for it.

    As for the sedative/narcotic effects of benadryl, I can say that when naive to the effects of diphenhydramine, it is most similar to benzo's at a dose of 25-100, it becomes hallucinogenic at higher dosages, but not the good kind of hallucinogenic. DXM is an NMDA antagonist if I remember correctly, I can say that it is mildly hallucinogenic at a dosage of 200mg, but is more of a euphoric/intoxicant, its when you start getting up into the stratosphere on dosages that things get nasty.

    And yes, Lysergic Acid Diethylamide FTW
  40. MrSquat's Avatar
    Join Date
    Oct 2008
    Age
    52
    Posts
    57
    Rep Power
    100

    Reputation

    Quote Originally Posted by arizonanewbie View Post
    I can speak from experience that dextromethorpan is no joke - highly hallucinogenic. I mean like mushrooms or acid.
    Good reason. It is related to Morphine.
  

  
 

Similar Forum Threads

  1. Replies: 4
    Last Post: 04-27-2011, 06:17 PM
  2. Replies: 7
    Last Post: 03-10-2011, 02:57 PM
  3. Diphenhydramine
    By MrBrightside in forum Supplements
    Replies: 12
    Last Post: 02-28-2009, 06:26 PM
  4. Somnidren with diphenhydramine
    By Aeternitatis in forum Millennium Sport Technologies
    Replies: 11
    Last Post: 05-01-2008, 04:13 PM
  5. Benadryl (Diphenhydramine) on cycle?
    By CryingEmo in forum Anabolics
    Replies: 5
    Last Post: 08-14-2007, 03:41 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in
Single Sign On provided by vBSSO