Benadryl (diphenhydramine) aids recovery?

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  1. Benadryl (diphenhydramine) aids recovery?


    Recently I have been taking 50mg of benadryl before bed to prevent the down-regulation of the beta-2 receptor from ephedrine and I have noticed that my muscular recovery seems to have improved. I am wondering about how benadryl could improve recovery. I would guess that it may be due to a reduction or inhibition of histamine-induced cortisol secretion (histamine has been shown to enhance secretion of ACTH and cortisol);

    Histamine-induced cortisol secretion from bovine a...[Jpn J Pharmacol. 1997] - PubMed Result

    (WO/2007/076140) TREATMENT METHODS EMPLOYING HISTAMINE H3 RECEPTOR ANTAGONISTS, INCLUDING BETAHISTINE

    Has anyone else experienced this?


  2. I use it with valerian root and melatonin for sleep. Didn't know it had anothe benifits.
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  3. antihistamines can also lower testosterone levels

    your improved recovery is due to improved sleep
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  4. melatonin and ZMA and valerian

  5. I'm with Sinner... I bet its due to better/deeper sleep.
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  6. I'll tell you one thing:

    Nothing, absolutely nothing beats good sleep. You can take all the stims and crap you want, but sleep >>>>>>>>>>> everything when it comes to feeling good, having energy, and recovery.

  7. Benadryl is an antihistamine which inhibits the H1 receptors. This action causes a decrease in smooth muscle swelling, (Ie. the muscles lining your airways and blood vessels.) and itchiness. Both of which occur in an allergic reaction. In profound cases overstimulation of the H1 receptors leads to a narrowing of the airway to the point of suffocation.

    I can't see there being any effect of benadryl which would aid in muscle recovery. I have to agree with those on here who said ithat your results was due to better sleep.

  8. Quote Originally Posted by atjnutrition2 View Post
    Benadryl is an antihistamine which inhibits the H1 receptors. This action causes a decrease in smooth muscle swelling, (Ie. the muscles lining your airways and blood vessels.) and itchiness. Both of which occur in an allergic reaction. In profound cases overstimulation of the H1 receptors leads to a narrowing of the airway to the point of suffocation.

    I can't see there being any effect of benadryl which would aid in muscle recovery. I have to agree with those on here who said ithat your results was due to better sleep.
    yeah dude. diphenhydramine can be some nasty stuff at high doses. Gets you high, and puts you in a VERY dangerous condition. I knew some kids in high school who were sent to the hospital after taking a bottle of benedryl each.
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  9. not trying to hijack the thread--but dextromethorphan is another terrible one kids are using.

  10. Quote Originally Posted by atjnutrition2 View Post
    not trying to hijack the thread--but dextromethorphan is another terrible one kids are using.
    Mmmm Robitussin. That was my favorite cough syrup when I was younger.
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  11. Quote Originally Posted by thesinner View Post
    yeah dude. diphenhydramine can be some nasty stuff at high doses. Gets you high, and puts you in a VERY dangerous condition. I knew some kids in high school who were sent to the hospital after taking a bottle of benedryl each.
    Being in the medical profession, I can honestly tell you it's absolutely amazing that benadryl is over the counter. There is a medication called "atarax" or "vistaril" which is literally the same thing, however it's controlled and by prescription administration only. Unreal man. The benadryl hangover is aweful to some people. I will say though, benadryl has its place overall.

    I think what most people don't realize is that benadryl is a parasympathetic inhibitor(Autonomic Nervous system). Basically, that means it can and will increase your heart rate and blood pressure by inhibiting the parasympathetic response. This in itself is bad for many people especially with pre-existing medical conditions of cardiac nature(WPW: Wolf Parkinson's White Syndrome to be exact....or really an re-entry mechanism disease of the heart)

    Benadryl is very often prescribed as a sleep aid for many people. Hell, atarax is prescribed for anti-anxiety issues.....and that's basically like taking a benadryl.

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  12. Quote Originally Posted by Trauma1 View Post
    Being in the medical profession, I can honestly tell you it's absolutely amazing that benadryl is over the counter. There is a medication called "atarax" which is literally the same thing that is controlled and by prescription administration. Unreal man. The benadryl hangover is aweful to some people. I will say though, benadryl has its place overall.

    I think what most people don't realize is that benadryl is a para-sympathetic inhibitor. Basically, that means it can and will increase your heart rate and blood pressure by inhibiting the para-sympathetic response. This in itself is bad for many people especially with pre-existing medical conditions of cardiac nature(WPW: Wolf Parkinson's White Syndrome to be exact.)

    Benadryl is very often prescribed as a sleep aid for many people. Hell, atarax is prescribed for anti-anxiety issues.....and that's basically like taking a benadryl.

    nice posting, plz give us more info on sleep aids and everything master !

  13. Quote Originally Posted by nycste View Post
    nice posting, plz give us more info on sleep aids and everything master !

    Where have you been bud?

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  14. Trauma--just curious...in what way are you in the medical field. Been a firefighter/medic for 11 years.

  15. Quote Originally Posted by atjnutrition2 View Post
    Trauma--just curious...in what way are you in the medical field. Been a firefighter/medic for 11 years.
    Emergency Room nurse for almost 8 years.....most of it in a trauma setting....thus the name.

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  16. Figured something like that. Thanks for all you guys do, truly is you guys that keep ER's running.

  17. Quote Originally Posted by atjnutrition2 View Post
    Figured something like that. Thanks for all you guys do, truly is you guys that keep ER's running.
    And like wise my friend. I have many fire/medic buddies. You guys equally do an amazing job in what you do. My dad was a fireman when we lived in CT for many years.....i wanted to do it, but i can't do heights bro haha. The healthcare system works pretty well when there are competent people at all ends of the spectrum.

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  18. I can speak from experience that dextromethorpan is no joke - highly hallucinogenic. I mean like mushrooms or acid.

  19. Quote Originally Posted by arizonanewbie View Post
    I can speak from experience that dextromethorpan is no joke - highly hallucinogenic. I mean like mushrooms or acid.
    I find it hard to believe that anything outside peyote or PCP even remotely comes close to a good acid trip, however dextromethorphan has been known to cause hallucinations in large doses.

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  20. Mescaline!!! Call it by the name of the compound, not the cactus it is often found in.


    There's a whole plethora of ergot alkaloids (i.e. LSD, Ergoline, etc.).
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  21. Quote Originally Posted by thesinner View Post
    Mescaline!!! Call it by the name of the compound, not the cactus it is often found in.


    There's a whole plethora of ergot alkaloids (i.e. LSD, Ergoline, etc.).
    I know!!! I'm at work and not much time to type.

    Lysergic Acid Diethylamide FTW.

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  22. Quote Originally Posted by Trauma1 View Post
    I know!!! I'm at work and not much time to type.

    Lysergic Acid Diethylamide FTW.
    yay dopamine!

    (or in the case of LSD, dopamine, adrenaline, seratonin, and probably some glutamate as well. )
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  23. Ya that **** can mess you up! I have random allergic reactions like once every 2 years, use to think it was from peanuts, but really not sure. Usually just after onset I have to drink a bottle of benadryl and not have to go to the hospital. My eyes swell completly closed, and I break out in rashes, and can feel my airway constricting! The stuff saves my life! But after you drink a bottle, your are really messed up!

  24. Quote Originally Posted by mathis50262 View Post
    Ya that **** can mess you up! I have random allergic reactions like once every 2 years, use to think it was from peanuts, but really not sure. Usually just after onset I have to drink a bottle of benadryl and not have to go to the hospital. My eyes swell completly closed, and I break out in rashes, and can feel my airway constricting! The stuff saves my life! But after you drink a bottle, your are really messed up!

    You should also keep a histamine-2 blocker around the house such as, pepcid(famotidine), zantac(ranitidine), or tagamet(cimetidine). They also assist in blocking the histamine cascade that leads to full blown anaphylaxis. Benadryl and an H-2 blocker together can save your life.

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  25. Quote Originally Posted by Trauma1 View Post
    You should also keep a histamine-2 blocker around the house such as, pepcid(famotidine), zantac(ranitidine), or tagamet(cimetidine). They also assist in blocking the histamine cascade that leads to full blown anaphylaxis. Benadryl and an H-2 blocker together can save your life.
    For some reason our EMS chief decided to take promethazine off of our trucks. Great H2 blocker, also was outstanding when pushing iv pain meds.
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