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January 15, 2007
Low dose aspirin associated with reduced asthma risk
Low dose aspirin every other day reduced the risk of developing asthma in a large scale clinical trial, concluded Tobias Kurth, MD, ScD of Brigham and Women's Hospital in Boston and colleagues after examining data from the double-blind Physician's Health Study. Asthma is a chronic inflammatory disease that causes breathing difficulties which is estimated to affect over 20 million Americans. Dr Kurth and his coauthors reported the finding in the January 15, 2007 issue of the American Thoracic Society journal American Journal of Respiratory and Critical Care Medicine.
The Physician's Health study involved 22,071 healthy male physicians between the age of 40 and 84 who consumed low-dose aspirin or a placebo on alternate days. The study was terminated after 4.9 years when a dramatic 44 percent reduction in the risk of a first heart attack was found among those who received aspirin. Participants were given the opportunity to report a diagnosis of asthma at the beginning of the study, at six months, and yearly thereafter. One hundred thirteen out of the 11,037 men who received aspirin developed asthma, compared with 145 who received a placebo. The risk reduction was not found to be affected by smoking status, body mass index, or age. "Aspirin reduced the risk by 22 percent of newly-diagnosed adult-onset asthma," Dr. Kurth observed. "These results suggest that aspirin may reduce the development of asthma in adults."
"They do not imply that aspirin improves symptoms in patients with asthma," he added. "Indeed, asthma can cause severe bronchospasm in some patients who have asthma. Because asthma was not the primary endpoint of the U. S. Public Health Service study, additional randomized trials would be helpful to confirm the apparent reduction in asthma incidence caused by aspirin."
Low dose aspirin associated with reduced asthma risk
Low dose aspirin every other day reduced the risk of developing asthma in a large scale clinical trial, concluded Tobias Kurth, MD, ScD of Brigham and Women's Hospital in Boston and colleagues after examining data from the double-blind Physician's Health Study. Asthma is a chronic inflammatory disease that causes breathing difficulties which is estimated to affect over 20 million Americans. Dr Kurth and his coauthors reported the finding in the January 15, 2007 issue of the American Thoracic Society journal American Journal of Respiratory and Critical Care Medicine.
The Physician's Health study involved 22,071 healthy male physicians between the age of 40 and 84 who consumed low-dose aspirin or a placebo on alternate days. The study was terminated after 4.9 years when a dramatic 44 percent reduction in the risk of a first heart attack was found among those who received aspirin. Participants were given the opportunity to report a diagnosis of asthma at the beginning of the study, at six months, and yearly thereafter. One hundred thirteen out of the 11,037 men who received aspirin developed asthma, compared with 145 who received a placebo. The risk reduction was not found to be affected by smoking status, body mass index, or age. "Aspirin reduced the risk by 22 percent of newly-diagnosed adult-onset asthma," Dr. Kurth observed. "These results suggest that aspirin may reduce the development of asthma in adults."
"They do not imply that aspirin improves symptoms in patients with asthma," he added. "Indeed, asthma can cause severe bronchospasm in some patients who have asthma. Because asthma was not the primary endpoint of the U. S. Public Health Service study, additional randomized trials would be helpful to confirm the apparent reduction in asthma incidence caused by aspirin."
