I honestly cant say, I am taking ZMA, vitamin c and now I hear even vitamin A wich is in my multi can lower estradiol, so I would hope my E2 is lower then it was, although theres a chance its higher and I have had itchy nipples wich mostly subsided before starting the DIM. I do notice hot flashes when I take DIM and that is a symptom of estrogen dropping so I guess that could be a good sign although anoying. My libido is higher but not neccesarily when I take the DIM even if I skip a day, wich doesnt make sense because DIM has a half life of only 4 hours, but then again this libido could be because I have lowered my T dose, so its all really hard to say right now.
Down the track when everything is settled with TRT treatment I will try get a blood test with DIM and without DIM.