Warning - Serotonin Syndrome
- 03-25-2005, 11:55 PM
Warning - Serotonin Syndrome
This is a heads-up to the one or two bros here that take anti-depressants. I take lexapro (20mg) and wellbutrin (150mg) ED. For better or for worse, I am also prone to experimentation with chems (well, I guess we all are or we wouldn't be on this board, right?) Yesterday afternoon I picked up a supp containing 5-htp and tyrosine. Thinking that "if a little serotonin is good, then more would be better" I popped two caps before lunch - the dosage was small and I wasn't the least bit concerned.
Thirty minutes later, I was laying on the floor of a public building puking my guts out. I was intensely dizzy, my extremities were numb, and I was sweating like I had run a marathon. A passer-by thought I was having a MI and called an ambulance.
Dudes, this sucked so bad that it is hard to put into words. If you're on prescription meds, PLEASE do your homework before you take anything that has the potential to effect neurotransmitter levels in a significant way.
- 03-25-2005, 11:59 PM
03-26-2005, 01:09 AM
Dude, it sucked like a Hoover. If projectile vomiting were an olympic sport, I would have won the gold...AND the silver.
I'm disappointed because I want to try phenibut, but now I'm afraid. Is anyone aware of a potential reaction b/t Phenibut / lexapro/ wellbutrin?
Originally Posted by prime
03-26-2005, 06:24 PM
Try going of the wellbutrin and lexapro and just trying St.johns wort. I have read of many people doing that. It will work just as well, but you may have to take some time off for the scripts to clear your system first. I read a lot about it on Kelly's St.johns wort page forum.
03-31-2005, 02:36 AM
i use phenibut (great stuff) and i am on an ssri (zoloft) and it doesn't interfere at all. phenibut will increase gaba output (gaba mimetic) to cause rlaxation and better sleep.wellbutrin works on dopamine receptors i believe and should not react w/ phenibut. oh, and thanx for the heads up on the 5-htp.
03-31-2005, 05:04 PM
i wouldnt **** with st. johns, I have heard that it works well with mild depression but can make moderate or severe depression worse.
03-31-2005, 05:16 PM
What?!??!?! Where did you hear that crap?. I have been taking it for years and so have a lot of people! Here, take a look at this link and in the forums...What you have heard is a bunk of BULL****!.Originally Posted by UNDERTAKER
04-01-2005, 01:57 PM
I have 'heard' that a recent study proved that ST. John's wort had no scientific benefit for clinically depressed patients compared to placebo. Don't have the study handy but surely someone who works in this area could chime in...
04-01-2005, 02:05 PM
Although SJW seems to have some merit, I don't think it would be a good idea for me to abandon the medication I take now. The function and interaction between the various neurotransmitters has not been fully elucidated, and the effects of being "off" for a time followed by introduction of SJW are unknown. For someone with moderate depression/anxiety, it would be difficult to determine the proper dose of SJW and how it might interact with other medications, so I think this is a risky proposition.Originally Posted by T-Bone
The serotonin syndrome was a terrible experience and one that I do not wish to repeat. It appears that there is little room for error when dealing with neurotransmitters.
04-01-2005, 02:07 PM
Saint John's didn't do too much for me, it would lift my mood for a day or so then it would come crashing back down even worse. It does not work for everyone so, can have annoying sides like insomnia, photosensitvity and negation of birth control pills in women.
It's not a panacea for depression and I don't care if an herb site touts it as a miracle or not.
I've had far better luck with ALCAR, folic acid, garlic and selenium. Go figure.
04-01-2005, 05:58 PM
It all depends on the brand you get. It is prescibed in Germany for depression and has been for decades. You should not take it if you haven't been diagnosed with depression and/or anxiety disorder, or been prescibed and SSRI. Of course come off the SSRI and make sure its out of your system before you start the SJW. There is plenty of information on about it on the site I linked. It has been studied more than creatine, and is proven safe and effective. If you want to read over boring studies, go ahead and search for them. You have to take the correct dosage and some of the brands out there are just crap and don't work at all. Look over that site, it has plenty of info.
04-02-2005, 01:02 PM
04-02-2005, 06:36 PM
Doc, could you expound on this a little bit? I would like to give phenibut or PA's Gabatropin a try (or maybe even kratom), but after my 5htp/tyrosine disaster I'm a little hesitant when it comes to neurotransmitters. I would love to find something that can help me relax and/or induce sleep - but the possibility of a negative interaction is something that I wish to avoid like the plague.Originally Posted by DR.D
Right now I take 150/day of wellbutrin and 20mg per day of lexapro. My knowledge of the actions and interactions of these compounds is poor, but it's my understanding that bupropion increases norepinephrine and, to a smaller extent, dopamine. In contrast, lexapro is an SSRI with fewer side effects than the older tri-cyclics.
Can you shed any light on how phenibut would intereact with the other two?
04-02-2005, 07:36 PM
Phen is a GABA modulator, which will reduce the effectiveness of the Bu and Lex. Lex is an atypical SSRI, it activates rather than sedates. And while Bu has some relaxing effects uncharacteristic of most adrenergics, it's a strong cardioaccelerant to me, so it hypes me too. If your trying to relax, I recommend a combo more like Bu/zoloft or Bu/pamelor or Bu/Xanax or even just Serzone or Cylert solo. That's why I say the Phen may help to take the edge off. Lex is strong stuff, maybe you could even reduce the dose and still retain the benefits. I have taken every combo you can think of with this kind of stuff, so trust me that a benzo or the Phen would be great to add to the combo. Of course, Phen does little for me so I suggest a real benzo. Ativan is my fav. for it's versitility. Maybe you can talk to you doc. Tell me exactly what you want from this, and I'll tell you what to tell him to get what you need.Originally Posted by utk1976
04-03-2005, 02:21 PM
Hey doc D. what do you think about Tianeptine (stablon)? Im researching near and far, Ive got what seems to be stress induced anxiety/depression together with HPA burnout and this looks real promising...
04-03-2005, 04:24 PM
Thanks for the info Doc. I'll add the Phen in later this month. I am fairly happy with the Bu/lex combo, but at the same time, I'm always looking to teak things to get the most benefit with the fewest side effects. The Bu picks me up a little, so I take it first thing in the morning and save the Lexapro for late afternoon/evening. I was on Lexapro 20mg for a full year before I asked my doc about Wellbutrin. For me, Bu has been a miracle drug. It doesn't make me high (ala amphetamine) or give some wonderful buzz, but it does help reduce the intensity and frequency of depressive episodes - and that's great by me.Originally Posted by DR.D
I've been reading about people's experiences with Phen for quite a while now, so I'm thinking of adding it into the mix...perhaps around 8 or 9 pm. It's my understanding that Phen is used in Europe to treat some cases of insomnia, so it sounds like a good fit for me. Right now I sometimes take Amitryptilene (sp?) in the evening just for the sleep inducing effects, but it tends to leave me a little groggy. I have taken both Xanax and Valium before (experimentation) and agree that they would be a good addition. As you might have guessed, however, my Doctor (and those in this area generally) are hesitant to write a script for scheduled drugs.
04-03-2005, 07:52 PM
It's a ring expanded tricyclic SSRI. I've never used it, but it's suppose to be as effective as others in the range of 12.5-25mg/d without all the sexual sides. Doc's are eager to try new stuff on you and always have a closet full of samples, just tell him you want to try it for a month. It's probably neutral as for mental stimulation/sedation.Originally Posted by judge-mental
04-04-2005, 04:26 AM
That is an extreme reaction,but it doesnt surprise me I guess once u think about it,serotonin(and the rest of the hormonal slew)are very extreme 'thangs'..doesnt take much to make an extreme shift of some sort,good or bad.When on any kind of script drug u have to know ALL the 'improper combos' bet they never told you not to mix with 5-htp and/or tyrosine did they?Good warning bro.
Curious what you tried before you went on meds for depression?High dose fish oils,nute deficience tests/multis,anything natural or diet/mental wise before u decided to go script for it?
04-04-2005, 07:58 PM
I had same thing was freezing and thinking of heatshock same time,while heart-rate was way up >200bpm.
I was on Caffein,yohimbine and a fenoterol-asthma spray,which I uses 4times instead of 2x in a short time.
Had fear of a heart5stroke,cause power was more than my heart could manage in my system,so I decided to eat something despite of the intense nausea and kept running on submximal levels.
I wonder if that´s even possible with these drugs,maybe a panick-attack?
04-05-2005, 11:02 PM
I played around with 5htp and tyrosine before I went for the scripts.Originally Posted by juggernaut333
I also tried self-medicating with alcohol, which is a dead end. I love it when you run into a guy or girl who drinks every day but believes that they don't have a problem and that meds are for wusses.
I tried cinching up my sack and toughing things out. If you really have depression, this doesn't work at all.
Going to see my doc and getting a script was the best thing I've ever done. Unfortunately, my jackass doc started me out on lexapro at 10mg a day - way too little. If you or someone you know is having trouble, go see a doc.
04-06-2005, 12:57 PM
04-14-2005, 02:23 PM
I just ordered some Kanna from iamshaman.com and the dosage is 350 mg, but on most websites people are taking 50-100 mg. Do you think I should just split the cap in 1/2 or would the 350 be alright? Just wanting to make sure my brain doesn't get all messed up.
04-16-2005, 03:44 PM
yeah i have found that after a serotonin imbalance from taking Sam-E 4 years ago, that now i can take it and its the single most effective thing i have found for my mild depression. Weird how your body adapts and can de-sensitize itself or enhance the effetiveness of certain products. For now Sam-E (200-400mg), Alcar (2-3g), Piracetam (2-4g) and lecithina nd Alpha GPC are doing me well for my depression. I am alot more focused. I also use theanine to get to sleep sometimes. Eph/Caffeine is great but not in excess only when ineed a kick in the ass at work.
04-16-2005, 05:29 PM
Iv'e used Phenibut with both Wellbutrin and Zoloft(Not Zoloft and Welbutrin at the same time though) and had no problems. Although the Phen dosn't seem to be working as well as it use to, even at high doeses. I just bought some Kanna and Kratom, and plan on trying them this week. I'll let you know how it goes with the Zoloft.
Originally Posted by utk1976
07-21-2005, 09:00 PM
Hey doc, do you mean Lexapro causes more serotonin output rather than blocking the recpetors? If so, what about a combination of Prozac and Lexapro? I am currently taking Prozac 70mgs/Klonopin 1.5mgs/Buspar 40mgs a day with Adderall XR 20mgs on work days.
07-21-2005, 09:08 PM
Right, it increases turnover by uptake inhibition, so more serotonin is released than normal. You really don't need it with the Prozac. BTW, that's a lot of Prozac! A lot of Buspar too which may be oppositional to the Prozac. You could sub Lex for Prozac but both could be used together at lower doses, like 10mg Lex w/ 20mg Pro.Originally Posted by thecrunk
07-22-2005, 02:20 AM
Dr. D, what would be best for social anxiety? Some days I am fine as can be and other days suck. Prescription or OTC, something that I could use for a while as a crutch until I didn't need it anymore. Thanks.
07-22-2005, 05:11 AM
I am not sure I am understanding 100% here...Lexapro actually stimulates the release of serotonin while Prozac inhibits the reuptake right? The Buspar is taken 20mgs twice a day. The reseason the Prozac is so high is because I have OCD.Originally Posted by DR.D
07-22-2005, 06:35 PM
SSRI's work great. Prozac is good but it plays out after a few months. Luvox @ 25-50mg/d is the best IMO. Also, benzo's like lorazepam work well for this too in my experience. Don't get discouraged, there is something out there that will work for you, you just have to find it.Originally Posted by darius
07-22-2005, 06:40 PM
You may do better with a benzo than Buspar. Xanax or Ativan may be better for you from the sound of it. The Prozac works just like the Lex, only the Lex is the latest fad. I liked it, but it was not as effective as older drugs like Zoloft and Paxil. Still, either will be fine for OCD. You may want to give the Prozac a 2 wk break and then start again. It seems to be more effective if you cycle it. You can increase the Lex an extra 10mg in the meantime if you do that.Originally Posted by thecrunk
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