[Ghosting]

Originally Posted by DR.D

GABA is part of the RAS. Drugs affecting it will attenuate the effects of Lexapro ane Wellbutarin.

I dont doubt your knowledge . Ive taken zolpidem tartrate (aka Ambien). Ambein binds preferentially to the omega-1 (BZ-1) receptor subtype of the GABA receptor complex. I am on fluoxetine (aka Prozac) and have taken Ambein with no ill effects. So a better statement would be, I have been fine taking it. Thinking about it, its only a 20mg dose and the effects of combinding the 2 may be nowhere near my threshold for seratonin. Oops. Bad advice.

[DR.D]

Yeah, Ambien is some crazy stuff alright! I agreed with your comment, my point was really just that it can influence those other systems, not that they were incompatable.

QUOTE=Ghosting]I dont doubt your knowledge . Ive taken zolpidem tartrate (aka Ambien). Ambein binds preferentially to the omega-1 (BZ-1) receptor subtype of the GABA receptor complex. I am on fluoxetine (aka Prozac) and have taken Ambein with no ill effects. So a better statement would be, I have been fine taking it. Thinking about it, its only a 20mg dose and the effects of combinding the 2 may be nowhere near my threshold for seratonin. Oops. Bad advice.[/quote]

[Ghosting]

Originally Posted by DR.D

Yeah, Ambien is some crazy stuff alright! I agreed with your comment, my point was really just that it can influence those other systems, not that they were incompatable.

I didnt realize inhibitors would impact transmitters. Thanks for the info.

[DR.D]

Originally Posted by Ghosting

I didnt realize inhibitors would impact transmitters. Thanks for the info.

It doesn't diectly. It modulates incoming signals from external stimuli, so it justs blunts the expression of those transmitters. They are necessarily limited as a result of that type of inhibition. So they are OK to use together, but the GABA stimulation (what you are calling inhibition) is oppositional to the effectiveness of the others.

[Ghosting]

Originally Posted by DR.D

It doesn't diectly. It modulates incoming signals from external stimuli, so it justs blunts the expression of those transmitters. They are necessarily limited as a result of that type of inhibition. So they are OK to use together, but the GABA stimulation (what you are calling inhibition) is oppositional to the effectiveness of the others.

So if I understand you correctly, you are saying GABA will make them "less effective" (I know that is a terrablie desciption ).

[Ghosting]

Or I should say we see them as less effective.

[DR.D]

Originally Posted by Ghosting

So if I understand you correctly, you are saying GABA will make them "less effective" (I know that is a terrablie desciption ).

No, you said it just fine. That is the bottom line. It will reduce the aptitude of their effects. These drugs work in part by promoting the release of these transmitters. With the GABA reducing the signals that come in, these higher systems are not stimulated as much as they could be with these drugs. That's why a benzo (GABA agonist) live Ativan or Ambiem promotes sleep and can be used to control withdrawl from many of these CNS stims.

[bioman]

DARIUS- Forselean is just a concentrated brand of Coleus forskohli. You could simply take cAMPIBOLIC and add a seperate dose of Rhodiola in a few times per day. I might switch to that strategy just save my capping supplies.

Thanks for your thoughts and prayers regarding my wife.

She is doing quite well and we may even drop her off the Effexor entirely within the next day or two. RR seems to be keeping the usual withdrawal symptoms at bay, however she is either going through "detox" or she has a cold that is staying at exactly the same intesity for 3 days now. I think it's a detox reaction myself but it's hard to know.

Mentally..she's doing great and this has been a blessing. I'ts good to see her relaxed and happy again. Without a doubt I'll be keeping us both on RR forever. Hopefully it does not lose it's effectiveness over time. All the literature I've perused suggests that even though you have to stay on it for the benfits, there are no signs of dimishing effects.

Thanks again everyone, for you help and input. AM rocks!

[DR.D]

That sounds great Bio! I love happy endings...

[Ghosting]

Its too bad regular OTC GABA doesnt pass the BBB, it would be pretty popular if it did.

[RipdnTxs]

glad to here your wife is doing better, my wife is on prozac, her family has a history of pretty major depression, she sleeps every time she gets a chance, on weekends at lunch and even when she comes home from work in the evenings and still goes to bed around 8:30 p.m. if she can, anyone have any suggestions on what I could give her to help with this, it is hard living with a person like this and I would really like to help her. Thanks

[bioman]

RIPD- I'd start with the list of vitamins and aminos listed above. Regular dosing of folic acid, selenium and chromium are crucial so treat it just like taking meds..religiously. I feel comfortable enough suggesting these 3 as they can't hurt you in any way. If they help..it's wonderful...if not, well then there's always meds and what-not.

Even though it's early in my own "experiment" I would still highly recommend Rhodiola rosacea at 100-200 mg, 3 times per day. It's seriously the most under rated herbal depression and anxiety treatment around IMO.

Acetyl L Carnitine (ALCAR) dosed at 1-4 grams per day will certainly help give her more energy and "awake time".

I used to have fairly severe depression like hers..where I'd just craved sleep rather than dealing with reality. ALCAR, the vitamins, and now Rhodiola have turned that around 180 degrees for me.

Key issue is taking the supps faithfully everyday.

Good luck and if you need any more details don't hesitate to ask in this thread.


UPDATE: Wife did indeed have a cold..which she gave to me. That's the thanks I get, lol.

She has ceased Effexor dosing now for 3 days with no symptoms outside of her cold and a bit of fatigue. The Effexor definitelty drained her of energy very badly to where she would cry over not being able to do much besides go to work, come home, eat and go to bed...so yeah, that's a real helpful way to combat depression and anxiety. lol

RR has stopped her anxiety cold and brightened her mood nicely. She often had "heart palipitations" over the last year or so that neither a 24 hour heart monitoring nor a stress echo test could confirm or diagnose. Those appear to be gone.

Once the cold is gone, the last metabolites of Effexor out of her system, I'll be better able to monitor her improvements.

[DR.D]

Originally Posted by RipdnTxs

glad to here your wife is doing better, my wife is on prozac, her family has a history of pretty major depression, she sleeps every time she gets a chance, on weekends at lunch and even when she comes home from work in the evenings and still goes to bed around 8:30 p.m. if she can, anyone have any suggestions on what I could give her to help with this, it is hard living with a person like this and I would really like to help her. Thanks

Get all her nutrients in place (like Bio has done for his wife) and if that isn't enough, you may consider an adrenergic stim like Adderal or Dexadrine. MAOI also work well for this type of depression, but they are rough on the liver and impose dietary restictions.

[RipdnTxs]

Thanks for the replys, I just ordered some camph. and I will get some alcar., I will post back about results when she starts taking them....

[darius]

Dr. D, what is your opinion on using something like Phenibut for social anxiety? What would the dosing be? If the dosing is high, arn't there tolerance issues?

What about Klonopin? I have heard that this works well for social anxiety as well. What is your opinion on Klonopin?

Thanks