Unfortunately, there is a reason why she is taking warfarin for the long-term. In Factor V Leiden cases where patients have many clotting events that have occured or have a risk for future clotting events, long-term therapy is needed. Heparins and low molecular weight heparins are an option to warfarin but they are injected and thus warfarin, as an oral drug, is prefferable. Long-term warfarin therapy is only somewhat associated with adverse events, usually being a hemmorage. What i have gathered the highest population percentage in a study was 3%. I must agree that the dosage is quite high, but there must be some reason that the doctor has opted for this dose. What i would reccomend is talk with her physician about any concerns you or she may have.