Cordycepin (3'-deoxyadenosine)

[Olympus Labs]

This thread is to open up discussion on the natural testosterone booster that Olympus will be launching in the near future. This product will highlight key ingredients that all work synergistically to give users maximum results. In particular, we are very impressed with the ingredient listed below which will be included at its clinical dosage.

Cordycepin, or 3'-deoxyadenosine is an ingredient which has the characteristics of being a pro-sexual, anti-inflammatory, anti-oxidant, anti-aging, anti-tumor, anti-leukemic, anti-proliferative, anti-metastatic, immunomodulatory, anti-microbial, anti-bacterial, anti-viral, anti-fungal, larvicidal, anti-fibrotic, steroidogenic, anti-diabetic, anti-HIV, anti-malarial, anti-fatigue, neuroprotective, liver-protective, reno-protective as well as being a pneumo-protective ingredient.

The recommended dosage is 100mg/serving. We're going to be including this high grade extract in our natural testosterone booster which will be launching late fall / mid winter.

As a testosterone booster:

Researchers investigated the in vivo and in vitro effects of Cordycepin in primary mouse Leydig cell steroidogenesis. [1] The results indicated that Cordycepin significantly increased the plasma Testosterone concentration. Cordycepin also stimulated in vitro mouse Leydig cell Testosterone production in dose- and time-dependent manners.

Cordycepin resembles adenosine in chemical structure, so the metabolic pathways of Cordycepin inside body should closely mimic those of adenosine. Researchers in the study proved this hypothesis. It has been confirmed that mouse testis contain several adenosine receptors, and Cordycepin activates the cAMP-PKA signal transduction pathway to induce StAR protein expression, and then enhances Testosterone production, possibly by
exerting its effect through adenosine subtype receptors A1, A2a, and A3.

According to the Testosterone elevation report, another research found long-term administration of Cordycepin could reverse the decline of testicular function induced with age. [2] In this piece of research, scientists divided the rats into a young group, a middle-aged group and treated the middle-aged group with Cordycepin. The middle-aged group exhibited epididymal weight loss, decreased sperm motility, and reduced spermatogenesis compared to the young control group. Interestingly enough, the epididymal weights of middle-aged rats were dose-dependently increased by long-term treatment with Cordycepin. Cordycepin also
improved calcium levels and decreased urea and nitrogen, uric acid, and creatinine in the blood of middle-aged rats. In addition, Cordycepin significantly increased sperm motility and the progressiveness of sperm movement. All Cordycepin-treated groups showed well-arranged spermatogonia, densely packed cellular material, and increased numbers of mature spermatozoa in the seminiferous lumen compared to the middle-aged control group.

References:
1. Sew-Fen LEU, Song Ling Poon, et al. The in vivo and in vitro stimulatory effects of Cordycepin on mouse Leydig cell steroidogenesis. Biosci. Biotechnol. Biochem., 75(4), 723-731, 2011.

2. Sang-Hyun Sohn, Su-Chan Lee, et al. Effect of Long-term Administration of Cordycepin from Cordyceps militaris on Testicular Function in Middle-aged Rats. Planta Med 2012; 78: 1620–1625.

 

[grinnell27]

Sounds really impressive and a lot of research has been carried out.

 

[g0hardorgohom]

Can't wait!

 

[Contaygious]

Whoa!

Wait what about this? Is this old now?
http://www.jbc.org/content/285/4/2610.full

"Surprisingly, at higher doses cordycepin also inhibits cell adhesion and virtually abolishes protein synthesis, probably through its effects on Akt and 4EBP phosphorylation. The most upstream target of cordycepin at higher doses appears to be AMPK, which it activates, leading to the observed reduction in mTOR signaling. Therefore the two main effects of cordycepin appear to be the inhibition of polyadenylation at low doses and the activation of AMPK at higher doses."

 

[MrKleen73]

Contaygious I started to look at that but it is quite long so i will revisit it later. I think the question that comes to mind is what is considered a high dose in that study? If you have read it can you shed some light. I am not sure when I will be able to sit and read the whole thing.

 

[Contaygious]

Cordycepin inhibits protein synthesis. A, protein synthesis rates of NIH3T3 cells as measured by 35S incorporation into protein, corrected for total protein concentration. The effects of treatment with 200 μM cordycepin or adenosine or with 10 μg/ml actinomycin D (AcD) are shown. B, polyribosome profiles of control cells and cells treated with cordycepin (200 μM) for 2 h. 40S and 60S indicate the dissociated free ribosomal subunit peaks, polysomes indicates ribosomes translating mRNA. The inset shows the RNA isolated from a control gradient, proving the identification of the 40 S peak. C, dose response of the effect of cordycepin on protein synthesis rates in NIH3T3 cells treated for 2 h. D, time course of the response of protein synthesis rates to three doses of cordycepin. E, dose response of the effect of cordycepin on protein synthesis rates in HeLa cells treated for 2 h. F, incorporation of radioactive methionine into protein in vitro in reticulocyte lysate supplemented with cordycepin, adenosine, cordycepin triphosphate (cordyTP), ATP, or cap analogue (m7GpppG) (all at 200 μM).

 

[MrKleen73]

Cordycepin inhibits protein synthesis. A, protein synthesis rates of NIH3T3 cells as measured by 35S incorporation into protein, corrected for total protein concentration. The effects of treatment with 200 μM cordycepin or adenosine or with 10 μg/ml actinomycin D (AcD) are shown. B, polyribosome profiles of control cells and cells treated with cordycepin (200 μM) for 2 h. 40S and 60S indicate the dissociated free ribosomal subunit peaks, polysomes indicates ribosomes translating mRNA. The inset shows the RNA isolated from a control gradient, proving the identification of the 40 S peak. C, dose response of the effect of cordycepin on protein synthesis rates in NIH3T3 cells treated for 2 h. D, time course of the response of protein synthesis rates to three doses of cordycepin. E, dose response of the effect of cordycepin on protein synthesis rates in HeLa cells treated for 2 h. F, incorporation of radioactive methionine into protein in vitro in reticulocyte lysate supplemented with cordycepin, adenosine, cordycepin triphosphate (cordyTP), ATP, or cap analogue (m7GpppG) (all at 200 μM).

Yes but you mentioned this was only the case with high doses or the part of the article you put up there showed that, unless I misread your post. So the question is what was the mass ratio of the cells treated compared to the 200 μM cordycepin and is that even a dose that would be considered in the application intended by our use. If much higher than what we intend to use for our purposes then the findings of this study hold no merit to the current intended application. Unfortunately I am not a scientist so I am not sure how to pull that info out of the study we are looking at with so much info and so little time. Once i have had a chance to dig into this I will discuss further instead of making any concrete statements out of context.

 

[MrKleen73]

Upon reading some of the types of cells used it looks like this study may have been target at cells known to be heavily effected by leukemia, if so targeted inhibition of protein synthesis in those types of cells is not a negative and does not necessarily mean that it will have the same effect on muscular cells. I will keep looking and maybe Spaniard can have a look as well he is well versed in studies.

 

[Contaygious]

Word, just asking since it came up when searching the ingredient! Im not familiar those dosages

 

[alvin1]

Will it be in your upcoming test booster?

 

[T-Bone]

This thread is to open up discussion on the natural testosterone booster that Olympus will be launching in the near future. This product will highlight key ingredients that all work synergistically to give users maximum results. In particular, we are very impressed with the ingredient listed below which will be included at its clinical dosage.

Cordycepin, or 3'-deoxyadenosine is an ingredient which has the characteristics of being a pro-sexual, anti-inflammatory, anti-oxidant, anti-aging, anti-tumor, anti-leukemic, anti-proliferative, anti-metastatic, immunomodulatory, anti-microbial, anti-bacterial, anti-viral, anti-fungal, larvicidal, anti-fibrotic, steroidogenic, anti-diabetic, anti-HIV, anti-malarial, anti-fatigue, neuroprotective, liver-protective, reno-protective as well as being a pneumo-protective ingredient.

Will it be in your upcoming test booster?

LMAO!

 

[cubs1987]

intradesting. Subbed

 

[T-Bone]

I be straight Cordycepin!

 

[alvin1]

LMAO!

You got me bitch!

 

[Contaygious]

Where is it

 

[alvin1]

This thread is to open up discussion on the natural testosterone booster that Olympus will be launching in the near future. This product will highlight key ingredients that all work synergistically to give users maximum results. In particular, we are very impressed with the ingredient listed below which will be included at its clinical dosage.

Cordycepin, or 3'

It did not make it into king blood any specific reason?