1. Simopoulos, A.P. and Childs, B., Eds., Genetic Variation and Nutrition, vol. 63, World
Rev. Nutr. Diet., Karger, Basel, 1990.
2. Simopoulos, A.P., Herbert, V., and Jacobson, B., The Healing Diet: How to Reduce
Your Risks and Live a Longer and Healthier Life If You Have a Family History of
Cancer, Heart Disease, Hypertension, Diabetes, Alcoholism, Obesity, Food Allergies,
Macmillan Publishers, New York, 1995.
3. Simopoulos, A.P. and Nestel, P.J., Eds., Genetic Variation and Dietary Response, vol.
80, World Rev. Nutr. Diet., Karger, Basel, 1997.
4. Simopoulos, A.P. and Pavlou, K.N., Eds., Nutrition and Fitness 1: Diet, Genes,
Physical Activity and Health, vol. 89, World Rev. Nutr. Diet., Karger, Basel, 2001.
5. Simopoulos, A.P., Genetic variation and dietary response: nutrigenetics/nutrigenomics,
Asian Pacific J. Clin. Nutr., 11(S6), S117, 2002.
6. Simopoulos, A.P. and Ordovas J., Eds., Nutrigenetics and Nutrigenomics, vol. 93,
World Rev. Nutr. Diet., Karger, Basel, 2004.
7. Eaton, S.B. and Konner, M., Paleolithic nutrition. A consideration of its nature and
current implications. New Engl. J. Med., 312, 283, 1985.
8. Simopoulos, A.P., Omega-3 fatty acids in health and disease and in growth and
development, Am. J. Clin. Nutr., 54, 438, 1991.
9. Simopoulos, A.P., Genetic variation and evolutionary aspects of diet, in Antioxidants
in Nutrition and Health, Papas, A., Ed., CRC Press, Boca Raton, FL, 65, 1999.
10. Simopoulos, A.P., Evolutionary aspects of omega-3 fatty acids in the food supply,
Prostaglandins, Leukotrienes Essential Fatty Acids, 60(5&6), 421, 1999.
11. Simopoulos, A.P., New products from the agri-food industry: the return of n-3 fatty
acids into the food supply, Lipids 34(suppl), S297, 1999.
12. Cordain, L., Cereal grains: humanity’s double-edged sword, World Rev. Nutr. Diet.,
84, 19, 1999.
13. Simopoulos, A.P., Ed., Plants in Human Nutrition, vol. 77, World Rev. Nutr. Diet.,
Karger, Basel, 1995.
14. Zeghichi, S., Kallithraka, S., and Simopoulos, A.P., Nutritional composition of
molokhia (Corchorus olitorius) and stamnagathi (Cicorium spinosum), World Rev.
Nutr. Diet., 91, 1, 2003.
15. Zeghichi, S., et al., The nutritional composition of selected wild plants in the diet of
Crete, World Rev. Nutr. Diet., 91, 22, 2003.
16. Simopoulos, A.P., Omega-3 fatty acids and antioxidants in edible wild plants, Biol.
Research, 37(2), 263, 2004.
17. Simopoulos, A.P., Ed., Evolutionary Aspects of Nutrition and Health. Diet, Exercise,
Genetics and Chronic Disease, vol. 84, World Rev Nutr Diet., Karger, Basel, 1999.
18. Fanaian, M., et al., The effect of modified fat diet on insulin resistance and metabolic
parameters in type II diabetes, Diabetologia, 39(suppl 1), A7, 1996.
19. Simopoulos, A.P., Is insulin resistance influenced by dietary linoleic acid and trans
fatty acids? Free Rad. Biol. & Med., 17(4), 367, 1994.
20. Simopoulos, A.P., Fatty acid composition of skeletal muscle membrane phospholipids,
insulin resistance and obesity, Nutr. Today, 2, 12, 1994.
21. Simopoulos, A.P. and Robinson, J., The Omega Diet. The Lifesaving Nutritional
Program Based on the Diet of the Island of Crete. HarperCollins, New York, 1999.
22. Eaton, S.B., Konner, M., and Shostak, M., Stone agers in the fast lane: chronic
degenerative diseases in evolutionary perspective, Am. J. Med., 84, 739, 1988.
23. Eaton, S.B., et al., Dietary intake of long-chain polyunsaturated fatty acids during
the Paleolithic, World Rev. Nutr. Diet., 83, 12, 1998.
24. Leaf, A. and Weber, P.C., A new era for science in nutrition, Am. J. Clin. Nutr., 45,
25. Simopoulos, A.P., The Mediterranean diet: Greek column rather than an Egyptian
pyramid, Nutr. Today, 30(2), 54, 1995.
26. Simopoulos, A.P., Overview of evolutionary aspects of w3 fatty acids in the diet,
World Rev. Nutr. Diet., 83, 1, 1998.
27. Simopoulos, A.P., Evolutionary aspects of diet and essential fatty acids, World Rev.
Nutr. Diet., 88, 18, 2001.
28. Simopoulos, A.P., Evolutionary aspects of diet: Fatty acids, insulin resistance and
obesity, in Obesity: New Directions in Assessment and Management, VanItallie, T.B.
and Simopoulos, A.P., Eds., Charles Press, Philadelphia, 1995, 241.
29. Simopoulos, A.P., Trans fatty acids, Handbook of Lipids in Human Nutrition, Spiller,
G.A., Ed., CRC Press, Boca Raton, FL, 1995, 91.
30. Hunter, J.E., Omega-3 fatty acids from vegetable oils, in Biological Effects and
Nutritional Essentiality. Series A: Life Sciences, vol. 171, Galli, C. and Simopoulos,
A.P., Eds., Plenum Press, New York, 1989, 43.
31. Litin, L. and Sacks, F., Trans-fatty-acid content of common foods, N. Engl. J. Med.,
32. Raper, N.R., Cronin, F.J., and Exler, J., Omega-3 fatty acid content of the US food
supply, J. Am. College Nutr. 11(3), 304, 1992.
33. Crawford, M.A., Fatty acid ratios in free-living and domestic animals, Lancet, i, 1329,
34. Crawford, M.A., Gale, M.M., and Woodford, M.H., Linoleic acid and linolenic acid
elongation products in muscle tissue of Syncerus caffer and other ruminant species,
Biochem. J., 115, 25, 1969.
35. Ledger, H.P., Body composition as a basis for a comparative study of some East
African animals, Symp. Zool. Soc. London, 21, 289, 1968.
36. Cordain, L., et al., The fatty acid composition of muscle, brain, marrow and adipose
tissue in elk: evolutionary implications for human dietary requirements, World Rev.
Nutr. Diet., 83, 225, 1998.
37. Sinclair, A.J., Slattery, W.J., and O’Dea, The analysis of polyunsaturated fatty acids
in meat by capillary gas-liquid chromotography, J. Food Sci. Agric., 33, 771, 1982.
38. Sugano, M. and Hirahara, F., Polyunsaturated fatty acids in the food chain in Japan,
Am. J. Clin. Nutr., 71(suppl), 189S, 2000.
39. Pella, D., et al., Effects of an Indo-Mediterranean diet on the omega-6/omega-3 ratio
in patients at high risk of coronary artery disease: The Indian paradox, World Rev.
Nutr. Diet., 92, 74, 2003.
40. Sanders, T.A.B., Polyunsaturated fatty acids in the food chain in Europe, Am. J. Clin.
Nutr., 71(suppl), S176, 2000.
41. Brox, J.H., et al., Effects of cod liver oil on platelets and coagulation in familial
hypercholesterolemia (type IIa), Acta Med. Scand., 213, 137, 1983.
42. Joist, J.H., Baker, R.K., and Schonfeld, G., Increased in vivo and in vitro platelet
function in type II- and type IV-hyperlipoproteinemia, Thromb. Res., 15, 95, 1979.
43. Weber, P.C., Are we what we eat? Fatty acids in nutrition and in cell membranes:
cell functions and disorders induced by dietary conditions, Report No. 4, Svanoy
Foundation, Svanoybukt, Norway, 1989, 9.
44. Saynor, R., Verel. D., and Gillott, T., The long term effect of dietary supplementation
with fish lipid concentrate on serum lipids, bleeding time, platelets and angina,
Atherosclerosis, 50, 3, 1984.
45. Dehmer, G.J., et al., Reduction in the rate of early restenosis after coronary angioplasty
by a diet supplemented with n-3 fatty acids, N. Engl. J. Med., 319, 733, 1988.
46. Bottiger, L.E., Dyerberg, J., and Nordoy, A., Eds., N-3 Fish oils in clinical medicine.
J. Intern. Med, 225(suppl 1), 1, 1989.
47. Cartwright, I.J., et al., The effects of dietary w-3 polyunsaturated fatty acids on
erythrocyte membrane phospholipids, erythrocyte deformability, and blood viscosity
in healthy volunteers, Atherosclerosis, 55, 267, 1985.
48. Lewis, R.A., Lee, T.H., and Austen, K.F., Effects of omega-3 fatty acids on the
generation of products of the 5-lipoxygenase pathway, in Health Effects of Polyunsaturated
Fatty Acids in Seafoods, Simopoulos, A.P., Kifer, R.R., and Martin, R.E.,
Eds., Academic Press, Orlando, 1986, 227.
49. Weber, P.C. and Leaf, A., Cardiovascular effects of w3 fatty acids: atherosclerotic
risk factor modification by w3 fatty acids, in Health Effects of w3 Polyunsaturated
Fatty Acids in Seafoods, Simopoulos, A.P., et al., Eds., vol. 66, World Rev. Nutr. Diet.,
Karger, Basel, 1991, 218.
50. Barcelli, U.O., Glass-Greenwalt, P., and Pollak,V.E., Enhancing effect of dietary
supplementation with omega-3 fatty acids on plasma fibrinolysis in normal subjects,
Thromb. Res., 39, 307, 1985.
51. Radack, K., Deck, C., and Huster, G., Dietary supplementation with low-dose fish
oils lowers fibrinogen levels: a randomized, double-blind controlled study, Ann.
Intern. Med., 111, 757, 1989.
52. Sanders, T.A.B., Vickers, M., and Haines, A.P., Effect on blood lipids and hemostasis
of a supplement of cod-liver oil, rich in eicosapentaenoic and docosahexaenoic acids,
in healthy young men, Clin. Sci., 61, 317, 1981.
53. Brown, A.J. and Roberts, D.C.K., Fish and fish oil intake: effect on hematological
variables related to cardiovascular disease, Thromb. Res., 64, 169, 1991.
54. De Caterina, R., et al., Vascular prostcyclin is increased in patients ingesting n-3
polyunsaturated fatty acids prior to coronary artery bypass surgery, Circulation, 82,
55. Fox, P.L. and Dicorleto, P.E., Fish oils inhibit endothelial cell production of a plateletderived
growth factor-like protein, Science, 241, 453, 1988.
56. Shimokawa, H. and Vanhoutte, P.M., Dietary cod-liver oil improves endothelium
dependent responses in hypercholesterolemic and atherosclerotic porcine coronary
arteries, Circulation, 78, 1421, 1988.
57. Kremer, J.M., Jubiz, W., and Michalek, A., Fish-oil fatty acid supplementation in
active rheumatoid arthritis, Ann. Intern. Med., 106, 497, 1987.
58. Lee, T.H., et al., Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic
acids on in vitro neutrophil and monocyte leukotriene generation and
neutrophil function, N. Engl. J. Med., 312, 1217, 1985.
59. Endres, S., et al., The effect of dietary supplementation with n-3 polyunsaturated
fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear
cells, N. Engl. J. Med., 320, 265, 1989.
60. Khalfoun, B., et al., Docosahexaenoic and eisosapentaenoic acids inhibit in vitro
human endothelial cell production of interleukin-6, in Eicosanoids and Other Bioactive
Lipids in Cancer, Inflammation, and Radiation Injury 2, Honn, K.V., et al.,
Eds, Plenum Press, New York, 1997.
61. Kremer, J.M., Lawrence, D.A., and Jubiz,W., Different doses of fish-oil fatty acid
ingestion in active rheumatoid arthritis: a prospective study of clinical and immunological
parameters, in Dietary w3 and w6 Fatty Acids: Biological Effects and Nutritional
Essentiality, Galli, C. and Simopoulos, A.P., Eds., Plenum Publishing, New
York, 1989, 343.
62. Robinson, D.R. and Kremer, J.M., Summary of Panel G: rheumatoid arthritis and
inflammatory mediators, World Rev. Nutr. Diet., 66, 44, 1991.
63. Ross, R., Atherosclerosis — an inflammatory disease, N. Engl. J. Med., 340, 115,
64. Springer, T.A., Traffic signals for lymphocyte recirculation and leukocyte emigration:
the multistep paradigm, Cell, 76, 301, 1994.
65. Davies, M.J., et al., The expression of the adhesion molecules ICAM-1, VCAM-1,
PECAM, and E-selectin in human atherosclerosis, J. Pathol., 171, 223, 1993.
66. O’Brien, K.D., et al., Vascular cell adhesion molecule-1 is expressed in human
coronary atherosclerotic plaques: implications for the mode of progression of
advanced coronary atherosclerosis, J. Clin. Invest. 92, 945, 1993.
67. Poston, R.N., et al., Expression of intercellular adhesion molecule-1 in atherosclerotic
plaques, Am. J. Pathol. 140, 665, 1992.
68. Richardson, M., et al., Increased expression in vivo of VCAM-1 and E-selectin by
the aortic endothelium of normolipemic and hyperlipemic diabetic rabbits, Arterioscler.
Thromb. 14, 760, 1994.
69. Simopoulos, A.P., The role of fatty acids in gene expression: health implications,
Ann. Nutr. Metab., 40, 303, 1996.
70. Ge, Y-L., et al., Effects of adenoviral transfer of Caenorhabditis elegans n-3 fatty acid
desaturase on the lipid profile and growth of human breast cancer cells, Anticancer
Research, 22, 537, 2002.
71. Kang, Z.B., et al., Adenoviral transfer of Caenorhabditis elegans n-3 fatty acid
desaturase optimizes fatty acid composition in mammalian heart cells, Proc. Natl.
Acad. Sci. U.S.A., 98, 4050, 2001.
72. Kang, J.X., et al., Fat-1 mice convert n-6 to n-3 fatty acids, Nature, 427, 504, 2004.
73. de Lorgeril, M., et al., Mediterranean alpha-linolenic acid-rich diet in secondary
prevention of coronary heart disease, Lancet, 343, 1454, 1994.
74. de Lorgeril, M. and Salen, P., Modified Cretan Mediterranean diet in the prevention
of coronary heart disease and cancer, World Rev. Nutr. Diet., 87, 1, 2000.
75. Renaud, S., et al., Cretan Mediterranean diet for prevention of coronary heart disease.
Am. J. Clin. Nutr., 61(suppl), 1360S, 1995.
76. Cleland, L.G., et al., Linoleate inhibits EPA incorporation from dietary fish-oil supplements
in human subjects, Am. J. Clin. Nutr., 55, 395, 1992.
77. GISSI-Prevenzione Investigators, Dietary supplementation with n-3 polyunsaturated
fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione
trial, Lancet, 354, 447, 1999.
78. Li, Y., Kang, J.X., and Leaf, A., Differential effects of various eicosanoids on the
contraction of cultured neonatal rat cardiomyocytes, Prostaglandins, 54, 511, 1997.
79. Burr, M.L., et al., Effect of changes in fat, fish and fibre intakes on death and
myocardial reinfarction: diet and reinfarction trial (DART), Lancet, 2, 757, 1989.
80. Singh, R.B. et al., Randomized controlled trial of cardioprotective diet in patients
with recent acute myocardial infarction: results of one year follow up, Brit. Med. J.,
304, 1015, 1992.
81. Singh, R.B., et al., Randomized, double-blind, placebo-controlled trial of fish oil and
mustard oil in patients with suspected acute myocardial infarction: the Indian experiment
of infarct survival — 4, Cardiovasc. Drugs Ther., 11, 485, 1997.
82. Raheja, B.S., et al., Significance of the n-6/n-3 ratio for insulin action in diabetes,
Ann. N.Y. Acad. Sci., 683, 258, 1993.
83. James, M.J. and Cleland, L.G., Dietary n-3 fatty acids and therapy for rheumatoid
arthritis, Semin. Arthritis Rheum., 27, 85, 1997.
84. Broughton, K.S., et al. Reduced asthma symptoms with n-3 fatty acid ingestion are
related to 5-series leukotriene production, Am. J. Clin. Nutr., 65(4), 1011, 1997.
85. Laitinen, L.A., Laitinen, A., and Haahtela, T., Airway mucosal inflammation even in
patients with newly diagnosed asthma, Am. Rev. Respir. Dis., 147(3), 697, 1993.
86. Bartram, H.-P., et al., Effects of fish oil on rectal cell proliferation, mucosal fatty
acids, and prostaglandin E2 release in healthy subjects, Gastroenterology, 105, 1317,
87. Bartram, H.-P., et al. Missing anti-proliferative effect of fish oil on rectal epithelium
in healthy volunteers consuming a high-fat diet: potential role of the n-3:n-6 fatty
acid ratio, Eur. J. Cancer Prev., 4, 231, 1995.
88. Maillard, V., et al., N-3 and n-6 fatty acids in breast adipose tissue and relative risk
of breast cancer in a case-control study in Tours, France, Int. J. Cancer, 98, 78, 2002.
89. Maes, M., et al., Fatty acid composition in major depression: decreased omega 3
fractions in cholesteryl esters and increased C20:4 omega 6/C20:5 omega 3 ratio in
cholesteryl esters and phospholipids, J. Affect Disord., 38(1), 35, 1996.
90. Maes, M., et al., Lower serum high-density lipoprotein cholesterol (HDL-C) in major
depression and in depressed men with serious suicidal attempts: relationship with
immune-inflammatory markers, Acta Psychiatr. Scand., 95(3), 212, 1997.
91. Peet, M., et al., Depletion of omega-3 fatty acid levels in red blood cell membranes
of depressive patients, Biol. Psychiatry, 43(5), 315, 1998.
92. Stoll, A.L., et al., Omega-3 fatty acids in bipolar disorder: a preliminary double-blind
placebo-controlled trial, Arch. Gen. Psychiatry 56(5), 407, 1999.
93. Locke, C.A. and Stoll, A.L., Omega-3 fatty acids in major depression, World Rev.
Nutr. Diet., 89, 173, 2001.
94. Simopoulos, A.P. and Cleland, L.G., Eds., Omega-6/Omega-3 Essential Fatty Acid
Ratio: The Scientific Evidence, vol. 92, World Rev. Nutr. Diet., Karger, Basel, 2003.
95. Simopoulos, A.P., N-3 fatty acids and human health: defining strategies for public
policy, Lipids, 36, S83, 2001.
96. Graber, R., Sumida, C., and Nunez, E.A., Fatty acids and cell signal transduction, J.
Lipid Mediat. Cell Signal, 9, 91, 1994.
97. Clarke, S.D. and Jump, D.B., Dietary polyunsaturated fatty acid regulation of gene
transcription, Annu. Rev. Nutr., 14, 83, 1994.
98. Clarke, S.D., Romsos, D.R., and Leveille, G.A., Differential effects of dietary methylesters
of long chain saturated and polyunsaturated fatty acids on rat liver and adipose
tissue lipogenesis, J. Nutr., 107, 1170, 1977.
99. Clarke, S.D., Armstrong, M.K., and Jump, D.B., Nutritional control of rat liver fatty
acid synthase and S14 mRNA abundance, J. Nutr., 120, 218, 1990.
100. Clarke, S.D. and Jump, D.B., Fatty acid regulation of gene expression: a unique role
for polyunsaturated fats, in Nutrition and Gene Expression, Berdanier, C. and Hargrove,
J.L., Eds., CRC Press, Boca Raton, FL, 1993, 227.
101. Clarke, S.D. and Jump, D.B., Polyunsaturated fatty acid regulation of hepatic gene
transcription, Lipids, 31(suppl), 7, 1996.
102. Jump, D.B., et al., Coordinate regulation of glycolytic and lipogenic gene expression
by polyunsaturated fatty acids, J. Lipid Res., 35, 1076, 1994.
103. Tebbey, P.W., et al., Arachidonic acid down-regulates the insulin-dependent glucose
transporter gene (Glut 4) in 3T3-L1 adipocytes by inhibiting transcription and enhancing
mRNA turnover, J. Biol. Chem., 269, 639, 1994.
104. Limatta, M., et al., Dietary PUFA interfere with the insulin glucose activation of Ltype
pyruvate kinase. Mol. Endocrinol., 8, 1147, 1994.
105. Ntambi, J.M., Dietary regulation of stearoyl-CoA desaturase I gene expression in
mouse liver, J. Biol. Chem., 267, 10925, 1991.
106. DeWillie, J.W. and Farmer, S.J., Linoleic acid controls neonatal tissue-specific
stearoyl-CoA desaturase mRNA levels, Biochim. Biophys. Acta., 1170, 291, 1993.
107. Sellmayer, A., Danesch, U., and Weber, P.C., Effects of different polyunsaturated
fatty acids on growth-related early gene expression and cell growth, Lipids, 31, S37,
108. De Caterina, R. and Libby, P., Control of endothelial leukocyte adhesion molecules
by fatty acids, Lipids, 31(suppl), 57, 1996.
109. Robinson, D.R., et al., Dietary marine lipids suppress the continuous expression of
interleukin-1B gene transcription, Lipids, 31(suppl):23, 1996.
110. Kaminski, W.E., et al., Dietary omega-3 fatty acids lower levels of platelet-derived
growth factor mRNA in human mononuclear cells, Blood, 81, 1871, 1993.
111. Holian, O. and Nelson, R., Action of long-chain fatty acids on protein kinase C
activity: comparison of omega-6 and omega-3 fatty acids, Anticancer Res., 12, 975,
112. Lucas, A., et al., Breast milk and subsequent intelligence quotient in children born
premature, Lancet, 339, 261, 1992.
113. Eurocat Working Group, Prevalence of neural tube defects in 20 regions of Europe
and the impact of prenatal diagnosis 1980–86. J. Epidemiol. Community Health, 45,
114. Dwyer, J.H., et al., Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic
acid, and atherosclerosis, N. Engl. J. Med., 350, 29, 2004.