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03-06-2008, 08:19 PM
| #1 |
| Board Sponsor Board Sponsor  | Synthetic HDL, truly amazing I figured some of you science nuts out there would find this interesting. Anti-Inflammatory and Cardioprotective Activities of Synthetic High-Density Lipoprotein Containing Apolipoprotein A-I Mimetic Peptides Monica Gomaraschi, Laura Calabresi, Giuseppe Rossoni, Stefania Iametti, Guido Franceschini, John A. Stonik, and Alan T. Remaley Center E. Grossi Paoletti, Department of Pharmacological Sciences, University of Milan, Milan, Italy (M.G., L.C., G.F.); Molecular Disease Section, Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Milan, Italy (G.R.); Department of Molecular and Agroalimentary Sciences, University of Milan, Milan, Italy (S.I.); and Lipoprotein Metabolism Section, Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland (J.A.S., A.T.R.) Apolipoprotein A-I (apoA-I) mimetic peptides may represent an alternative to apoA-I for large-scale production of synthetic high-density lipoproteins (sHDL) as a therapeutic agent. In this study, the cardioprotective activity of sHDL made with either L37pA peptide or its D-stereoisomer, D37pA, was compared to sHDL made with apoA-I. The peptides were reconstituted with palmitoyl-oleoyl-phosphatidylcholine, which yielded sHDL particles comparable to apoA-I sHDL in diameter, molecular weight, and {alpha}-helical content. Pretreatment of endothelial cells with either peptide sHDL reduced tumor necrosis factor {alpha}-stimulated vascular cell adhesion molecule-1 expression to the same extent as apoA-I sHDL. In an isolated rat heart model of ischemia/reperfusion (I/R) injury, L37pA and D37pA sHDL significantly reduced postischemic cardiac contractile dysfunction compared to the saline control, as indicated by a 49.7 ± 6.4% (L37pA; P < 0.001) and 53.0 ± 9.1% (D37pA; P < 0.001) increase of left ventricular-developed pressure (LVDP) after reperfusion and by a 45.4 ± 3.4% (L37pA; P < 0.001) and 49.6 ± 2.6% (D37pA; P < 0.001) decrease of creatine kinase (CK) release. These effects were similar to the 51.3 ± 3.0% (P < 0.001) increase of LVDP and 51.3 ± 3.0 (P < 0.001) reduction of CK release induced by apoA-I sHDL. Consistent with their cardioprotective effects, all three types of sHDL particles mediated an approximate 20% (P < 0.001) reduction of cardiac tumor necrosis factor {alpha} (TNF{alpha}) content and stimulated an approximate 35% (P < 0.05) increase in postischemic release of prostacyclin. In summary, L37pA and D37pA peptides can form sHDL particles that retain a similar level of protective activity as apoA-I sHDL on the endothelium and the heart; thus, apoA-I mimetic peptides may be useful therapeutic agents for the prevention of cardiac I/R injury. IBE Technology Employee - Coming VERY soon: -X-Force Reformulation -X-Dream Reformulation -Neuroabalance -Reverse (The ONLY higher bioavailability Resveratrol product on the market) -Matrix Energy Capsules |
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03-06-2008, 09:01 PM
| #2 |
| NutraPlanet Fanatic Board Sponsor  | That's pretty kickass, honestly. Sure would help solve one of the issues with using androgens, eh? WWW.NUTRAPLANET.COM Stretch your body, stretch your mind...let Nutraplanet stretch your Dollar. Recomp Performance Nutrition - "Blood, Sweat, and Tears doesn't mean crying while you struggle to put your tampon in." ~dsade |
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03-06-2008, 09:21 PM
| #3 |
| I Know Nothing!! Board Moderator  | Get it in bulk..now. lol I AM watching you. |
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03-06-2008, 09:23 PM
| #4 | |
| NutraPlanet Fanatic Board Sponsor | Quote:
WWW.NUTRAPLANET.COM Stretch your body, stretch your mind...let Nutraplanet stretch your Dollar. Recomp Performance Nutrition - "Blood, Sweat, and Tears doesn't mean crying while you struggle to put your tampon in." ~dsade | |
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03-07-2008, 06:56 AM
| #5 | |
| Board Sponsor Board Sponsor | Quote:
 IBE Technology Employee - Coming VERY soon: -X-Force Reformulation -X-Dream Reformulation -Neuroabalance -Reverse (The ONLY higher bioavailability Resveratrol product on the market) -Matrix Energy Capsules | |
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03-07-2008, 07:56 AM
| #6 | |
| NutraPlanet Fanatic Board Sponsor | Quote:
Imagine...healthy Movie theatre Popcorn butter. /gag WWW.NUTRAPLANET.COM Stretch your body, stretch your mind...let Nutraplanet stretch your Dollar. Recomp Performance Nutrition - "Blood, Sweat, and Tears doesn't mean crying while you struggle to put your tampon in." ~dsade | |
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03-08-2008, 03:15 PM
| #7 |
| Registered User  | wow |
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03-08-2008, 04:27 PM
| #8 | |
| I Know Nothing!! Board Moderator | Quote:
I AM watching you. | |
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03-08-2008, 09:19 PM
| #9 | |
| Recovering AXoholic Board Sponsor  | Quote:
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03-08-2008, 09:24 PM
| #10 |
| Nevernude Rep   | Who wants to bet that Strategicmove already knows all about this, and can break it down so that even the most simpleminded person can understand it? Member: Blitzkrieg Ninja Brigade - What Up Kemo Sabe? "Life is too short to have anything but delusional notions about yourself." - Gene Simmons |
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03-08-2008, 11:16 PM
| #11 | |
| Registered User   |  Quote:
 ARTICLES: IGF-1/GH forum -> (Dat's - CJC-1295 & GHRP-6 (Basic Guides)): - Basic Guide: CJC-1295 - Basic Guide: Growth Hormone Secretagogues - Growth Hormone Administration vs. CJC-1295/GHRP-6 | |
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03-09-2008, 12:40 PM
| #12 | |
| Board Sponsor Board Sponsor | Quote:
IBE Technology Employee - Coming VERY soon: -X-Force Reformulation -X-Dream Reformulation -Neuroabalance -Reverse (The ONLY higher bioavailability Resveratrol product on the market) -Matrix Energy Capsules | |
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03-09-2008, 12:43 PM
| #13 | |
| Nevernude Rep | Quote:
Member: Blitzkrieg Ninja Brigade - What Up Kemo Sabe? "Life is too short to have anything but delusional notions about yourself." - Gene Simmons | |
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03-11-2008, 08:28 AM
| #14 |
| Banned  | yum i want some |
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