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Study findings on insulin resistance therapy are outlined in reports from Tufts University, Human Nutrition Research Center on Aging

NewsRx.com

09-27-07

Fresh data on insulin resistance are presented in the report "Surrogate markers of insulin resistance are associated with consumption of sugar-sweetened drinks and fruit juice in middle and older-aged adults." According to a study from the United States, "In this study, we examined the association between sugar-sweetened drink, diet soda, and fruit juice consumption and surrogate measures of insulin resistance. Sugar-sweetened drink, diet soda, and fruit juice consumption was estimated using a semiquantitative FFQ in 2500 subjects at the fifth examination (1991-1995) of the Framingham Offspring Study."

"Surrogate markers of insulin resistance measured in this study included fasting insulin, fasting glucose, homeostatic model assessment of insulin resistance, and the insulin sensitivity index (ISI(0,120)). Sugar-sweetened drink consumption was positively associated with fasting insulin (none vs. >or=2 servings/d, 188 vs. 206 pmol/L, P-trend or=2 servings/d, 5.28 vs. 5.18 mmol/L, P-trend=0.006), but not with fasting insulin (none vs. >or=2 servings/d, 200 vs. 188 pmol/L, P-trend=0.37) or ISI(0,120) (none vs. >or=2 servings/d, 26.0 vs. 27.0, P-trend=0.19) in multivariate models. Diet soda consumption was not associated with any surrogate measures of insulin resistance after adjustment for potential confounders (insulin: none vs. >or=2 servings/d, 195 vs. 193 pmol/L, P-trend=0.59; glucose: 5.26 vs. 5.24 mmol/L, P-trend=0.84; and ISI(0,120): 26.2 vs. 26.7, P-trend=0.37). In these healthy adults, sugar-sweetened drink consumption appears to be unfavorably associated with surrogate measures reflecting hepatic more than peripheral insulin sensitivity," wrote M. Yoshida and colleagues, Tufts University, Human Nutrition Research Center on Aging.

The researchers concluded: "Studies of long-term beverage consumption using more direct measures of insulin sensitivity are clearly warranted."

Yoshida and colleagues published the results of their research in the Journal of Nutrition (Surrogate markers of insulin resistance are associated with consumption of sugar-sweetened drinks and fruit juice in middle and older-aged adults. Journal of Nutrition, 2007;137(9):2121-7).

For additional information, contact M. Yoshida, Nutritional Epidemiology Program, Jean Mayer US Dept. of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111 USA..