Magic carnosine

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  1. An ethyl-ester carnosine would be stellar. Make it so!


  2. Depends on the affinity, I suppose. Initially I am curious about the neural effects, but I suppose an ester (though I have another in mind) would be effective in muscle.
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  3. Quote Originally Posted by Iron Warrior
    Yeah good point juggs. L-Carnosine is not as effective as a combo of L-Histidine & beta-alanine. Good thing that you mentioned glycation, that may be one of the big anti-aging breaktrhoughs. Maybe Dsade can get Sam to start a histidine & beta-alanine stack offer

    ive seen those mentioned but honestly not familiar with those two.for glutath. boosting?at what dosing?ill check em out and do a search too

    the glycation..its definately one of the big breakthrus bro.glycation is at least partially responsible for alzheimers and other cognitive degenerative diseases.carnosine seems to be one of the kings of controlling this garbage.

  4. real good post,thanks
    so an inject carnosine would have to be made in verys mall batches?how long are we talkin will it stay in solution?

    so histidine in what dosages then for our purposes?

    i still think it good to take the carn. orally right now till something better evolves.i just wonder what the % is

    Quote Originally Posted by ersatz
    My experiences with carno is that it is effective IM or even subq. If you're feeling particularly daring try injecting it in your lips. Fast assimilation into blood stream and systematic effect.

    Orally it's not effective due to poor bioavailability. I would think that it would be broken back into hist and b-ala and absorbed whereby it's transfered into msucle and reformed into carno. But this doesn't seem to be the case for whatever reason.

    Histidine is present in muscle so it's not necessary to supplement with when trying to increase carno levels. B-ala and the enzyme forming carno are the rate limiting factors.

    Problem with beta-alanine is several fold. First it can cause a niacin like flush which can affect preworkout usage. Second it uses the same transport pathway into the cell as taurine. Carnosine uses another pathway so no possible conflict. This isn't to say BA supplementation will lead to taurine deficiency but it probably isn't a good idea to take both simultaneously. Few if any studies showing ba to protect against glycation. While histidine and conversion enzyme exist in sufficient quantities to ensure conversion to carno in muscle tissue the same does not hold true for other tissues.

    Carnosine OTOH doesn't require conversion and thus offers protection against glycation. It's also doesn't induce flushing but has poor oral bio and is quite a bit more expensive.

    I would not mix the carno in with your SOD solution as it doesn't stay in soln for long. You can ask Animal his thoughts on adding carno but I don't think he recommends it either.

    Now, if there's an orally bioavailable form of carnosine I would be interested in giving it a try.

  5. Quote Originally Posted by juggernaut333
    i still think it good to take the carn. orally right now till something better evolves.i just wonder what the % is
    Juggies.. Juggies!!! First of all I miss you..

    Injectable is better than oral, and it's here already my friend.. **** I have some right here beside me. It's here cousin... the future is already here. lol

    and I'm backing out now.
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  6. yeah ubi,been wondering wtf happened to u man?glad to see u active here at least.
    u have it in solution is this a homebrew concoction or what?in one of the above posts someone mentions its not to stable for long periods in solution.how do u work it?

  7. Quote Originally Posted by juggernaut333
    yeah ubi,been wondering wtf happened to u man?glad to see u active here at least.
    u have it in solution is this a homebrew concoction or what?in one of the above posts someone mentions its not to stable for long periods in solution.how do u work it?
    I jumped off the boards after that sketchy DD crap that happened that sent ripples throughout. I figured I'd concentrate on my new wife, give up admin and modship, and just be regular Ubi.. kind of like when Superman decided to give up his powers... but less disparaging. lol


    Re: Carnosine, I bought it from a board sponsor that used to be here I think.. or maybe not. I forget.. Still holding nice though, don't know the cosolvents, but the carrier is oil.

  8. How much are you pinning with the oil soln? Water based solns aren't ideal for Carnosine as it tends to crash in 12 hours.

    L-hisitidine supplementation is superflous so don't bother sourcing it. Ethyl esterfication may work at elast for increasing msucle concentrations of carno. But beta-alanine already does this sufficiently and is relatively cheap. As such I so no reason to pursue increasing carno in muscles. Now an orally bioavailable version to prevent glycation and one that could cross the bbb would be very promising.

  9. Quote Originally Posted by Ubiquitous
    Yeah, I have a comment.

    Pins are cheap.

    ****in aye they're so cheap they make condoms feel expensive LOL

  10. I tried Injectable Carnosine (still have 2 btls. Muscle Research carries it Hope they are still a board sponsor). I would inject between 1-3 cc's (300-900mg) bilaterally into biceps, triceps, shoulders and to tell you the truth cant remember if I noticed much. But I think it did help my endurance i.e. less of a burn especially on biceps but not really anywhere else I think.

  11. i hear ya,thats good to know.

    so it is stable in an oil solution then,but not water.how do dosages correlate to this then?as im still wondering what % the oral is absorbed ...anyone have a solid number?5,30,70,5 ???

    if your looking for what..1-2 gram per day for anti-glycation.i just am wondering how much total oral would be needed to achieve this.with inject of course i would imagine its full %%

    Quote Originally Posted by Ubiquitous
    I jumped off the boards after that sketchy DD crap that happened that sent ripples throughout. I figured I'd concentrate on my new wife, give up admin and modship, and just be regular Ubi.. kind of like when Superman decided to give up his powers... but less disparaging. lol


    Re: Carnosine, I bought it from a board sponsor that used to be here I think.. or maybe not. I forget.. Still holding nice though, don't know the cosolvents, but the carrier is oil.
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